Zobrazeno 1 - 10
of 25
pro vyhledávání: '"H Stacey"'
Autor:
Neill H. Stacey, Masoud Neghab
Publikováno v:
Toxicology. 120:1-10
Occupational exposure to a mixture of two widely used aromatic hydrocarbon solvents, xylene and toluene, has been associated with a significant rise in the concentrations of serum bile acids (SBA). We have recently shown that toluene interferes with
Serum bile acids as a sensitive biological marker for evaluating hepatic effects of organic solvents
Autor:
Neill H. Stacey, Masoud Neghab
Publikováno v:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 5(2)
Serum bile acids (SBAs) are suggested as a potentially sensitive and specific indicator of liver function which, accordingly, could provide an early indication of hepatobiliary dysfunction. This offers advantages over more traditional parameters of l
Publikováno v:
Toxicology in Vitro. 10:665-674
It has previously been shown that trichloroethylene (TRI) and 1,1,2-trichloro-1,2,2-tri-fluoroethane (FC 113) interfere with the transport of bile acids by isolated human and rat hepatocytes in a dose-dependent and reversible manner. This finding may
Autor:
Neill H. Stacey, Samy A. Azer
Publikováno v:
Journal of Gastroenterology and Hepatology. 11:396-407
Hepatic sinusoidal uptake of bile acids is mediated by defined carrier proteins against unfavourable concentration and electrical gradients. Putative carrier proteins have been identified using bile acid photoaffinity labels and more recently using i
Autor:
Cheng-Long Bai, N. H. Stacey
Publikováno v:
Toxicology and Applied Pharmacology. 121:296-302
The effects of trichloroethylene (TRI) on bile acid transport in isolated rat hepatocytes have been studied using doses ranging from 0.5 to 4.0 μl/flask and a 20-min equilibration period. It was found that TRI caused a dose-related suppression of in
Autor:
Neill H. Stacey, V. Kefalas
Publikováno v:
Toxicology in Vitro. 7:235-240
The use of primary cultures of rat hepatocytes as an experimental model for interactive toxicity studies was evaluated by studying carbon tetrachloride (CCl(4)) and trichloroethylene (TRI). TRI is known to potentiate CCl(4)-induced hepatotoxicity in
Publikováno v:
Hepatology. 11:750-756
Isolated rat hepatocytes have been advocated as a model to study aspects of mechanism of chemicalinduced interference with biliary excretory function. Some technical problems do exist in studying efflux, such as the reuptake of the previously excrete
Publikováno v:
Toxicology and Applied Pharmacology. 102:80-90
The effects of chlorinated aliphatic hydrocarbon solvent exposure on hepatocellular transport of some model substrates have been investigated. Exposure of isolated hepatocytes to 1,1,1-trichloroethane or tetrachloroethylene resulted in suppression of
Publikováno v:
Biochemical Pharmacology. 42:193-195
Autor:
Masoud Neghab, Neill H. Stacey
Publikováno v:
Journal of toxicology and environmental health. 52(3)
Raised concentrations of serum bile acids (SBA) following occupational exposure to a number of halogenated aliphatic hydrocarbon solvents and after in vivo exposure of experimental animals to these substances have been reported in several studies in