Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Anna Mae Diehl, Ning-Ping Zhang, Ying Wang, Chen Yang, Xiuping Liu, Xue-Jing Liu, Wen‐Yue Dong, Chang Liu, Li Xie, Manal F. Abdelmalek, Jian Wu, Chenjian Gu, Kuo Du, Chen Niu
Publikováno v:
Liver Int
Background and aims Treatment of non-alcoholic steatohepatitis (NASH) is challenging, because suppressing fibrotic progression has not been achieved consistently by drug candidates currently in clinical trials. The aim of this study was to investigat
Autor:
Rajesh Kumar Dutta, Seh-Hoon Oh, Wen-Hsuan Yang, Jen-Tsan Ashley Chi, Kuo Du, Anna Mae Diehl, Tianai Sun
Publikováno v:
Liver Int
Background & aims The outcome of liver injury is dictated by factors that control the accumulation of myofibroblastic (activated) hepatic stellate cells (MF-HSCs) but therapies that specifically block this process have not been discovered. We evaluat
Background and AimsLiver fibrosis develops in the context of excessive oxidative stress, cell death and accumulation of myofibroblasts (MFs) derived from hepatic stellate cells (HSCs). Ferroptosis is a type of regulated cell death that can be caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef9c6e3dd3130b4a811e359e407a456
https://doi.org/10.1101/2019.12.23.886259
https://doi.org/10.1101/2019.12.23.886259
Autor:
Jeongeun Hyun, Anna Mae Diehl, Matthew B Friedersdorf, Youngmi Jung, Seh-Hoon Oh, Jack D. Keene, Richard T. Premont, Ji Eun Kim, Sihyung Wang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 3, Pp 1215-1229 (2018)
Background/Aims: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in cirrhosis. Because many factors interact to regulate expansion and regression of MF-HSC populations, eff
Autor:
Manal F. Abdelmalek, Richard T. Premont, Jeongeun Hyun, Mustafa R. Bashir, Cynthia A. Moylan, Kuo Du, Satish K. Chitneni, Ricardo Henao, Ayako Suzuki, Ying Wang, Anna Mae Diehl, Susanna Naggie
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 1-21 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 1-21 (2020)
Background & Aims Nonalcoholic steatohepatitis (NASH) occurs in the context of aberrant metabolism. Glutaminolysis is required for metabolic reprograming of hepatic stellate cells (HSCs) and liver fibrogenesis in mice. However, it is unclear how chan
Autor:
Sihyung Wang, Jaewook Lee, Hee-Jae Cha, Ji Eun Kim, Youngmi Jung, Eun-Yi Moon, Chanbin Lee, Anna Mae Diehl, Jeongeun Hyun
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
SCIENTIFIC REPORTS(7)
Scientific Reports
SCIENTIFIC REPORTS(7)
Scientific Reports
The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway. HSC functions declined in a TB4
Autor:
Diana Kimono, Muayad Albadrani, Firas Al Hasson, Prakash S. Nagarkatti, Anna Mae Diehl, Udai P. Singh, Sutapa Sarkar, Mitzi Nagarkatti, Varun Chandrashekaran, Ratanesh Seth, Daping Fan, Diptadip Dattaroy, Saurabh Chatterjee
Publikováno v:
Eur J Pharmacol
SsnB previously showed a promising role to lessen liver inflammation observed in a mouse model of NAFLD. Since NAFLD can progress to fibrosis, studies were designed to unravel its role in attenuating NAFLD associated fibrosis. Using both in vivo and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ae471c2803e962c33a94ef7ddf898d
https://europepmc.org/articles/PMC7193950/
https://europepmc.org/articles/PMC7193950/
Autor:
Gregory A. Michelotti, Mark L. Jewell, Marzena Swiderska-Syn, Richard T. Premont, Anna Mae Diehl, Guanhua Xie, Wing-Kin Syn
Publikováno v:
Hepatology. 64:232-244
Introduction: Adult liver regeneration requires induction and suppression of proliferative activity in multiple types of liver cells. The mechanisms that orchestrate the global changes in gene expression that are required for proliferative activity t
Autor:
Thiago A. Pereira, Isaac S. Chan, Márcia Maria de Souza, Wing-Kin Syn, Vivian Resende, Steve S. Choi, Alba Otoni, Mariana Verdelho Machado, Anna Mae Diehl, Guilherme Vaz de Melo Trindade, Paula Vieira Teixeira Vidigal, Elisângela Trindade Santos, Izabela Voieta, William Evan Secor, Rafal P. Witek, Zilton A. Andrade, José Roberto Lambertucci, Guanhua Xie, Fausto Edmundo Lima Pereira
Publikováno v:
Clinical Science (London, England : 1979)
Schistosomal egg antigens induce host bile ductular cells to proliferate and produce osteopontin (OPN), a pro-fibrogenic factor that stimulates hepatic stellate cells to become myofibroblasts. The numbers of OPN-producing bile ductules correlate with
Autor:
Alberto Bartolomé, Utpal B. Pajvani, Marica Meroni, Xiaobo Wang, Marcela Salomao, Paola Dongiovanni, Anna Mae Diehl, Mark J. Graham, Kyeong Jin Kim, Joel E. Lavine, Changyu Zhu, Luca Valenti, Robert F. Schwabe, Katherine P. Yates, Ira Tabas
Publikováno v:
Science translational medicine. 10(468)
Fibrosis is the major determinant of morbidity and mortality in patients with nonalcoholic steatohepatitis (NASH) but has no approved pharmacotherapy in part because of incomplete understanding of its pathogenic mechanisms. Here, we report that hepat