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pro vyhledávání: '"Céline Héraud"'
Autor:
Monica Pata, Manfred W. Kilimann, Jean Vacher, Adam Griffiths, Céline Héraud, Subramanya N.M. Pandruvada
Publikováno v:
The Journal of biological chemistry. 289(20)
Loss of Ostm1 leads to the most severe form of osteopetrosis in mice and humans. Because functional rescue of the osteopetrotic defect in these mice extended their lifespan from ∼3 weeks to 6 weeks, this unraveled a second essential role of Ostm1.
Publikováno v:
The Journal of biological chemistry. 283(45)
The most severe form of bone autosomal recessive osteopetrosis both in humans and in the gray-lethal (gl/gl) mouse is caused by mutations in the Ostm1 gene. Although osteopetrosis is usually associated with a defect in the hematopoietic-derived osteo