Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Neil Maclean"'
Autor:
Boaz Nachmias, Dilshad H. Khan, Veronique Voisin, Arvind S. Mer, Geethu Emily Thomas, Nadav Segev, Jonathan St-Germain, Rose Hurren, Marcela Gronda, Aaron Botham, Xiaoming Wang, Neil Maclean, Ayesh K. Seneviratne, Nathan Duong, Changjiang Xu, Andrea Arruda, Elias Orouji, Arash Algouneh, Razqallah Hakem, Liran Shlush, Mark D. Minden, Brian Raught, Gary D. Bader, Aaron D. Schimmer
Publikováno v:
Leukemia. 36:1283-1295
AML cells are arranged in a hierarchy with stem/progenitor cells giving rise to more differentiated bulk cells. Despite the importance of stem/progenitors in the pathogenesis of AML, the determinants of the AML stem/progenitor state are not fully und
Autor:
Geethu Emily Thomas, Kazem Nouri, Rose Hurren, Yongran Yan, Neil MacLean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Vito Spadevecchio, Aaron D. Schimmer
Publikováno v:
Blood. 140:8723-8724
Autor:
Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D Brown, Brian Raught, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadevecchio, Aaron D. Schimmer
Publikováno v:
Blood. 140:3005-3006
Autor:
Aaron D. Schimmer, Neil MacLean, Anders Eneroth, Vilma Rraklli, Paul Targett-Adams, Rose Hurren, Aniket Bankar, Marcela Gronda, Pedro Pinho, Mark D. Minden, Simon Kavanagh, Sara Moses, Helen Kylefjord, Johan Bylund, Biljana Rizoska, Mark Albertella, Thirushi Piyumika Siriwardena, Richard Bethell, Christina Rydergård, Xiaoming Wang, Stefan Norin
Publikováno v:
Haematologica
Autor:
Michael Andreeff, Marcela Gronda, Yoosu Na, Rose Hurren, Xiaoming Wang, Neil MacLean, Andrea Arruda, Sara Mirali, Hyeonjeong Kang, Dilshad H. Khan, Zoe Alaniz, Marina Konopleva, Li Zhang, Mark D. Minden, Yulia Jitkova, Jongbok Lee, Aaron D. Schimmer, Mingjing Xu
Publikováno v:
Blood
The combination of venetoclax and the hypomethylating agent azacytidine induces a high rate of complete responses in treatment-naïve older patients with acute myeloid leukemia (AML). Lee and colleagues elucidate a novel mechanism of action for the s
Autor:
Xiaoming Wang, Danny V. Jeyaraju, Marcela Gronda, Dana Yehudai, Sanduni U. Liyanage, Mark Albertella, Thirushi P. Siriwardena, Samir H. Barghout, Biljana Rizoska, Rose Hurren, Yulia Jitkova, Aaron D. Schimmer, Neil MacLean, Paul Targett-Adams
Publikováno v:
Haematologica
Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ. As acute myeloid leukemia
Autor:
Neil MacLean, Shawn Brennan, Adam C. Smith, Rose Hurren, Allison Berger, Xiaoming Wang, Razq Hakem, Marcela Gronda, Mark D. Minden, Sara Farshchi Zarabi, Simon Kavanagh, Tary Traore, G. Wei Xu, Aaron D. Schimmer, Emil F. Pai, Samir H. Barghout, Ondrej Halgas, Michael Milhollen, Marc L. Hyer, Parasvi S. Patel, Danny V. Jeyaraju
Publikováno v:
Leukemia. 33:37-51
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy for which new therapeutic approaches are required. One such potential therapeutic strategy is to target the ubiquitin-like modifier-activating enzyme 1 (UBA1), the initiating enzyme
Autor:
Geethu Emily Thomas, Grace Egan, Laura Garcia Prat, Botham Aaron, Veronique Voisin, Elias Orouji, Jordan M Chin, Boaz Nachmias, Kerstin B Kaufmann, Fieke W Hoff, Neil Maclean, Rose Hurren, Xiaoming Wang, Marcela Gronda, Andrea Arruda, Mark D. Minden, Gary D Bader, Steven M. Kornblau, John E. Dick, Aaron D Schimmer
Publikováno v:
Blood. 136:1-2
Mitochondrial metabolites affect epigenetic marks, but it is largely unknown whether mitochondrial metabolic enzymes can directly localize to the nucleus to regulate stem cell function in AML. Here, we discovered that the mitochondrial enzyme, Hexoki
Autor:
Dilshad H. Khan, Veronique Voisin, Jonathan St-Germain, Andrea Arruda, Geethu E. Thomas, Changjiang Xu, Rose Hurren, Elias Orouji, Mark D. Minden, Boaz Nachmias, Neil MacLean, Brian Raught, Ayesh K. Seneviratne, Gary D. Bader, Xiaoming Wang, Liran I. Shlush, Aaron D. Schimmer, Aaron Botham
Publikováno v:
Blood. 136:22-23
While most patients with acute myeloid leukemia (AML) achieve remission with initial therapy, the majority relapse leading to poor overall survival. Relapse is frequently driven by a rare subset of leukemic stem cells (LSC). Understanding biological
Autor:
Rebecca R. Laposa, Dana Yehudai, Rose Hurren, Xiaoming Wang, Daina Avizonis, Gaëlle Bridon, Shrivani Sriskanthadevan, Aisha Shamas-Din, Mark D. Minden, Marcela Gronda, Veronique Voisin, Thirushi P. Siriwardena, Sanduni U. Liyanage, Changjiang Xu, Aaron D. Schimmer, Gary D. Bader, Neil MacLean
Publikováno v:
Blood. 129:2657-2666
Mitochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from the mitochondria and cytoplasm. We performed gene expression profiling analysis of 542 human acute myeloid leukemia (AML) samples and identified 55