Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jordan S. Orange"'
Autor:
Jordan S. Orange, Riccardo Castagnoli, Elke Krüger, Marita Bosticardo, Robert A. Krance, Marietta M. de Guzman, Luigi D. Notarangelo, Lisa R. Forbes, M. Cecilia Poli, Ottavia M. Delmonte, Caridad Martinez, Frédéric Ebstein, Sarah K. Nicholas
Publikováno v:
Blood
Inborn errors of immunity that present with concomitant immunodeficiency and auto-inflammation are therapeutically challenging; furthermore, complexity is added when they are caused by mutations in genes that encode for proteins expressed beyond immu
Autor:
Musa Karakukcu, Ratnadeep Mukherjee, Lynne A. Wolfe, Aaron Morawski, Lixin Zheng, Niraj C. Patel, Samuel D. Chauvin, Helen F. Matthews, Brian Sellers, Julio C. Orrego-Arango, Tingyan He, Susan Price, Alexandre G. R. Day, Pankaj Mehta, Les R. Folio, Giulia Notarangelo, Jordan S. Orange, James T. Anibal, Evan M. Masutani, Pam Angelus, Chrysi Kanellopoulou, Claudia M. Trujillo-Vargas, Sally Hunsberger, David E. Kleiner, Suk See De Ravin, Jenna R.E. Bergerson, Michael J. Lenardo, Devika Kapuria, Matthew Biancalana, Gulbu Uzel, Mami Matsuda-Lennikov, Sebastian Gutierrez-Hincapie, Alex George, Camilo Toro, Jeffrey I. Cohen, Juan Zou, Ivan K. Chinn, Juan C. Ravell, Ping Jiang, Harry L. Malech, William A. Gahl, Ekrem Unal, Grégoire Altan-Bonnet, Matthias Mann, Kyle Binder, Turkan Patiroglu, Stefania Pittaluga, Astin Powers, Helen C. Su, Kimiyo Raymond, Marc G. Ghany, Sally J. Deeb, José Luis Franco, V. Koneti Rao
Publikováno v:
The Journal of clinical investigation, vol 130, iss 1
J Clin Invest
J Clin Invest
X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the magnesium transporter 1 (MAGT1) gene. We studied 23 patients with XMEN, 8 of whom were EBV naive. We observed lymphadenopathy
Autor:
Musa Karakukcu, Atar Lev, Michael J Kraakman, Fabian Hauck, Christoph Klein, Erdener Özer, Nesrin Gulez, Kaan Boztug, Jordan S. Orange, Ivan K. Chinn, Ido Somekh, Alejandro Gallón Duque, Megumi Tatematsu, Meino Rohlfs, Raffaele Conca, Tala Shahin, Ginette Schiby, Eliana Appella, Claudia M. Trujillo-Vargas, Artem Kalinichenko, Marini Thian, Ekrem Unal, José Luis Franco, Turkan Patiroglu, David Medgyesi, Tali Stauber, Raz Somech, Alper Özcan, Amos J. Simon, Yu Nee Lee, Catalina Martinez-Jaramillo, Jeffrey M. Jacobson, Thomas Magg, Jasmin Dmytrus, Ferah Genel, Omer Akcal
Publikováno v:
Blood
Dysregulated immune responses are essential underlying causes of a plethora of pathologies including cancer, autoimmunity, and immunodeficiency. We here investigated 4 patients from unrelated families presenting with immunodeficiency, autoimmunity, a
Myeloid malignancies with somaticGATA2mutations can be associated with an immunodeficiency phenotype
Autor:
Steven M. Kornblau, Sa A. Wang, Jordan S. Orange, Mansour Alfayez, Dimitrios P. Kontoyiannis, Courtney D. DiNardo, Sarah A. Bannon, Emily M. Mace
Publikováno v:
Leukemia & Lymphoma. 60:2025-2033
Germline mutations in GATA2 are associated with a complex immunodeficiency and cancer predisposition syndrome. Somatic GATA2mut in myeloid malignancies may impart a similar phenotype. We reviewed adult patients with a diagnosis of GATA2mut hematologi
Autor:
Maria Alejandra Clavijo-Salomon, Giorgio Trinchieri, Amiran Dzutsev, José Alexandre Marzagão Barbuto, Jordan S. Orange, Helioswilton Sales-Campos, Rosalba Salcedo, Lucia Silla, Karen S.C. Borbely, Emily M. Mace, Rodrigo X. Das Neves, Soumen Roy
Publikováno v:
Blood Adv
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Adaptive immune responses are acknowledged to evolve from innate immunity. However, limited information exists regarding whether encounters between innate cells direct the generation of specialized T-cell subsets. We aim to understand how natural kil
Autor:
Robert A. Krance, Caridad Martinez, Swati Naik, Bilal Omer, Feliz O. Seeborg, Hao Liu, Meenakshi Hegde, Imelda C. Hanson, Malcolm K. Brenner, Nabil Ahmed, Kathryn Leung, Carl E. Allen, Meng-Fen Wu, Jordan S. Orange, Ghadir Sasa, Yassine Khaled, Sarah K. Nicholas, William T. Shearer, Asaf D. Yanir, George Carrum, Nicholas L. Rider, Stephen Gottschalk, Ivan K. Chinn, Helen E. Heslop, Lenora M. Noroski, Lisa R. Forbes
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:1643-1650
There is a lack of consensus regarding the role and method of hematopoietic stem cell transplantation (HSCT) on patients with chronic granulomatous disease (CGD). Long-term follow-up after HSCT in these patient population is essential to know its pot
Publikováno v:
Vox Sanguinis. 113:430-440
BACKGROUND AND OBJECTIVES Our research aim is to model latent therapeutic demand (LTD) for the immunoglobulin replacement therapy (IgGRT) of primary immune deficiency disorders (PIDDs) in the USA. Given the high level of variability of IgGRT use and
Autor:
Caridad Martinez, Robert A. Krance, Nicholas L. Rider, Bilal Omer, Alexander Ngwube, William Shearer, Ghadir Sasa, Nabil Ahmed, Swati Naik, Stephen Gottschalk, Jordan S. Orange, Malcolm K. Brenner, Filiz O. Seeborg, Meng Fen Wu, Carl E. Allen, I. Celine Hanson, Helen E. Heslop, Lenora M. Noroski, Lisa R. Forbes, Sarah K. Nicholas, Hao Liu, Kathryn Leung, Meenakshi Hegde
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:537-541
Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder characterized by a triad of immunodeficiency, eczema, and thrombocytopenia. Currently, hematopoietic stem cell transplantation (HSCT) is the most reliable curative treatment with excellent re
Autor:
Hao Liu, Olga Dakhova, Meng-Fen Wu, Charles Y. Lin, Caroline Arber, Daniel Brenner, Malini Mukherjee, Rachel A. Hirsch, Jordan S. Orange, Christopher D. Nishimura, Leah Ott, Malcolm K. Brenner
Publikováno v:
Blood. 130:2739-2749
Adoptively transferred T-cell receptor (TCR)-engineered T cells depend on host-derived costimulation and cytokine signals for their full and sustained activation. However, in patients with cancer, both signals are frequently impaired. Hence, we devel
Publikováno v:
Blood
Natural killer cell deficiencies (NKDs) are an emerging phenotypic subtype of primary immune deficiency. NK cells provide a defense against virally infected cells using a variety of cytotoxic mechanisms, and patients who have defective NK cell develo