Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Aaron P. Rapoport"'
Autor:
Abhinav Deol, Amanda F. Cashen, N. Nora Bennani, Khoan Vu, Michael D. Jain, David B. Miklos, Sattva S. Neelapu, Brian T. Hill, Jason R. Westin, Julie M. Vose, Alison R. Sehgal, Julio C. Chavez, Aaron P. Rapoport, Lazaros J. Lekakis, Andre Goy, Patrick M. Reagan, Javier Munoz, Joseph P. McGuirk, Loretta J. Nastoupil, Lei Feng, Olalekan O. Oluwole, Saurabh Dahiya, Jay Y. Spiegel, Frederick L. Locke, Charalambos Andreadis, Yi Lin, Matthew A. Lunning, Armin Ghobadi
Publikováno v:
J Clin Oncol
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 38, iss 27
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 38, iss 27
PURPOSE Axicabtagene ciloleucel (axi-cel) is an autologous CD19-directed chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory large B-cell lymphoma (LBCL) on the basis of the single-arm phase II ZUMA-1 trial, which showed b
Autor:
Joseph A. Fraietta, Edward A. Stadtmauer, Aaron P. Rapoport, Bruce L. Levine, Wei-Ting Hwang, Dan T. Vogl, Adam D. Cohen, Megan M. Davis, Carl H. June, Adam Waxman, Don L. Siegel, Alfred L. Garfall, Michael C. Milone, Ehren K. Dancy, J. Joseph Melenhorst
Publikováno v:
Blood Advances. 3:2812-2815
Key points T cells from patients early in myeloma therapy exhibit better fitness for CAR T manufacturing than those from relapsed/refractory patients. CAR T cells may be more effective if manufactured from patients before onset of relapsed/refractory
Autor:
Adam M. Petrich, Koen van Besien, Justin Kline, Krishna Rao, Sreenivasa Nattam, Ajay Major, Amy S. Kimball, Aaron P. Rapoport, Kenneth J. Cohen, Bethany G. Sleckman, Sonali M. Smith, Theodore Karrison, Paul A. S. Fishkin
Publikováno v:
Haematologica. 107(7)
The PI3K/Akt/mTOR (PAM) axis is constitutively activated in multiple lymphoma subtypes and is a promising therapeutic target. The mTOR inhibitor temsirolimus (TEM) and the immunomodulatory agent lenalidomide (LEN) have overlapping effects within the
Autor:
Gwendolyn K. Binder, Thomas H. Faitg, Karen Chagin, Elliot Norry, Jean-Marc Navenot, Edward A. Stadtmauer, Trupti Trivedi, Karen Dengel, Aaron P. Rapoport, Daniel E. Lowther, Rafael G. Amado, Malini Iyengar, Luca Melchiori, Ashraf Badros, Ruoxi Wang
Publikováno v:
Blood Advances. 3:2022-2034
This study in patients with relapsed, refractory, or high-risk multiple myeloma (MM) evaluated the safety and activity of autologous T cells engineered to express an affinity-enhanced T-cell receptor (TCR) that recognizes a peptide shared by cancer a
Autor:
Ashkan Emadi, Zeba N. Singh, Mehmet H. Kocoglu, Aaron P. Rapoport, Vu H. Duong, Maria R. Baer, Ashraf Badros, Rima Koka, Ying Zou, Noa G. Holtzman
Publikováno v:
Leukemia & Lymphoma. 60:3577-3580
Outcomes and life expectancy for patients with multiple myeloma (MM) have improved substantially over the last two decades with advancements in therapy, including autologous stem cell transplantati...
Autor:
A. Sim, A. Lazaryan, Forat Lutfi, S. Kim, M. Davila, F. Locke, H. Liu, N. Figura, T. Nishihori, Pranshu Mohindra, C. Bachmeier, A E Dohm, B. Shah, M. Jain, T. Robinson, Aaron P. Rapoport, J. Chavez, Farhad Khimani, Saurabh Dahiya
Publikováno v:
Radiotherapy and Oncology. 161:S894-S895
Safety and efficacy of CAR T cells in a patient with lymphoma and a coexisting autoimmune neuropathy
Autor:
Saurabh Dahiya, Perry K. Richardson, Khushali Jhaveri, Aaron P. Rapoport, Ilana Schlam, Monica Peravali, Noa G. Holtzman, Vera Malkovska
Publikováno v:
Blood Adv
Key Points CAR T-cell therapy was safe and effective in a DLBCL patient with coexisting autoimmune neuropathy. CD19 CAR T-cell therapy may control refractory autoantibodies and monoclonal gammopathies.
Autor:
Elizabeth Hutnick, Saurabh Dahiya, Moaath Mustafa Ali, Ali Bukhari, Gabriela Sanchez-Petitto, Noa G. Holtzman, Kathleen Ruehle, Natalie Gahres, Jean Yared, Nancy M. Hardy, Aaron P. Rapoport, Forat Lutfi, Seung Tae Lee, David Gottlieb, Mehmet H. Kocoglu, Kim Hankey, Dong Kim, Jonathan Siglin
Publikováno v:
British journal of haematologyReferences. 192(1)
Autor:
Djordje Atanackovic, Ryan A. Metcalf, Patricia R. Slev, Adam M. Spivak, Robert C. Blaylock, Vicente Planelles, Mohammad M. Sajadi, Yue Zheng, Heather D. Mannuel, Erin T. Larragoite, Mary Steinbach, Aaron P. Rapoport, Tim Luetkens, Emily S Spivak, Thomas B. Martins, Kim G. Hankey, Stephanie V. Avila
Publikováno v:
Blood Advances
Key Points A severely immunocompromised patient with MM and COVID19 who received a convalescent plasma product showed SARS-CoV-2 clearance. The convalescent plasma showed humoral immunity against all structural SARS-CoV-2 proteins, which was successf
Autor:
Jay Y. Spiegel, Saurabh Dahiya, Khoan Vu, Miriam T. Jacobs, Abhinav Deol, Kathleen A. Dorritie, N. Nora Bennani, Julie M. Vose, David B. Miklos, Patrick M. Reagan, Matthew A. Lunning, Armin Ghobadi, Aaron P. Rapoport, Frederick L. Locke, Loretta J. Nastoupil, Charalambos Andreadis, John S. Tamaresis, Yi Lin, Michael D. Jain, Brian T. Hill, Joseph P. McGuirk, Olalekan O. Oluwole, Sattva S. Neelapu, Andre Goy, Javier Munoz, Lazaros J. Lekakis
Publikováno v:
Blood