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pro vyhledávání: '"Jingwu Xie"'
Publikováno v:
Cells, Vol 10, Iss 2030, p 2030 (2021)
Cells
Cells
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle
Publikováno v:
Journal of Biomedical Research
Pancreatic cancer, mostly pancreatic ductal adenocarcinoma (PDAC), is a leading cause of cancer-related death in the US, with a dismal median survival of 6 months. Thus, there is an urgent unmet need to identify ways to diagnose and to treat this dea
Publikováno v:
Archives of Toxicology. 89:179-191
Hedgehog (Hh) is first described as a genetic mutation that has “spiked” phenotype in the cuticles of Drosophila in later 1970s. Since then, Hh signaling has been implicated in regulation of differentiation, proliferation, tissue polarity, stem c
Publikováno v:
Cellular Signalling. 24:1222-1228
Hedgehog (Hh) signaling, via the key signal transducer Smoothened (SMO) and Gli transcription factors, is essential for embryonic development and carcinogenesis. While the biological relevance of hedgehog signaling to cancer is well established, very
Autor:
Jingwu Xie, Masato Fujisawa, Wen-Chin Huang, Akinobu Gotoh, Fray F. Marshall, Xiangyan Li, Katsumi Shigemura, Haiyen E. Zhau, Guodong Zhu, Leland W.K. Chung
Publikováno v:
The Prostate. 71:1711-1722
BACKGROUND Sonic hedgehog (Shh) signaling plays a pivotal role in stromal-epithelial interaction during normal development but its role in tumor-stromal interaction during carcinogenic progression is less well defined. Since hormone refractory prosta
Publikováno v:
Chinese Journal of Cancer
Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintena
Publikováno v:
Cancer Research. 78:LB-091
Gastric cancer is the third leading cause of cancer-related mortality worldwide. Currently, there are no specific therapeutic options to cure gastric cancer, and chemotherapy is frequently used. Some patients respond initially to chemotherapy but all
Publikováno v:
Oncogene. 29:469-481
The hedgehog pathway, initially discovered by two Nobel laureates Drs E Wieschaus and C Nusslein-Volhard in Drosophila, is a major regulator for cell differentiation, tissue polarity and cell proliferation. Studies from many laboratories reveal activ
Autor:
Jingwu Xie
Publikováno v:
Current Oncology Reports. 10:107-113
The hedgehog pathway, initially discovered in Drosophila by two Nobel laureates, Dr. Eric Wieschaus and Dr. Christiane Nüsslein-Volhard, is a major regulator for cell differentiation, tissue polarity, and cell proliferation. Studies from many labora
Autor:
Dongsheng Gu, Jingwu Xie
Publikováno v:
Cancers
Cancers, Vol 7, Iss 3, Pp 1684-1698 (2015)
Cancers, Vol 7, Iss 3, Pp 1684-1698 (2015)
As a major regulatory pathway for embryonic development and tissue patterning, hedgehog signaling is not active in most adult tissues, but is reactivated in a number of human cancer types. A major milestone in hedgehog signaling in cancer is the Food