Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Anna Mae Diehl"'
Publikováno v:
The Liver
Autor:
Brian B. Graham, Anna Mae Diehl, Marzena Swiderska-Syn, Kristen Robbins, Zhaoxing Pan, Shikha S. Sundaram, Kelley E. Capocelli, Ronald J. Sokol, Ann C. Halbower
Publikováno v:
Hepatology Communications, Vol 3, Iss 7, Pp 883-893 (2019)
Hepatology Communications
Hepatology Communications
Chronic intermittent hypoxia and hedgehog (Hh) pathway dysregulation are associated with nonalcoholic fatty liver disease (NAFLD) progression. In this study, we determined the relationship between obstructive sleep apnea (OSA)/nocturnal hypoxia and H
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 53:264-278
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of obesity-associated liver diseases and it has become the major cause of cirrhosis in the Western world. The high prevalence of NAFLD-associated advanced liver disease reflects both the
Publikováno v:
Journal of Hepatology. 68:550-562
Liver disease remains a leading cause of mortality worldwide despite recent successes in the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling an epidemic of chronic fatty liver disease for which there are cu
Autor:
Sihyung Wang, Jaewook Lee, Hee-Jae Cha, Ji Eun Kim, Youngmi Jung, Eun-Yi Moon, Chanbin Lee, Anna Mae Diehl, Jeongeun Hyun
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
SCIENTIFIC REPORTS(7)
Scientific Reports
SCIENTIFIC REPORTS(7)
Scientific Reports
The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway. HSC functions declined in a TB4
Autor:
Diana Kimono, Muayad Albadrani, Firas Al Hasson, Prakash S. Nagarkatti, Anna Mae Diehl, Udai P. Singh, Sutapa Sarkar, Mitzi Nagarkatti, Varun Chandrashekaran, Ratanesh Seth, Daping Fan, Diptadip Dattaroy, Saurabh Chatterjee
Publikováno v:
Eur J Pharmacol
SsnB previously showed a promising role to lessen liver inflammation observed in a mouse model of NAFLD. Since NAFLD can progress to fibrosis, studies were designed to unravel its role in attenuating NAFLD associated fibrosis. Using both in vivo and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ae471c2803e962c33a94ef7ddf898d
https://europepmc.org/articles/PMC7193950/
https://europepmc.org/articles/PMC7193950/
Autor:
Gregory A. Michelotti, Mark L. Jewell, Marzena Swiderska-Syn, Richard T. Premont, Anna Mae Diehl, Guanhua Xie, Wing-Kin Syn
Publikováno v:
Hepatology. 64:232-244
Introduction: Adult liver regeneration requires induction and suppression of proliferative activity in multiple types of liver cells. The mechanisms that orchestrate the global changes in gene expression that are required for proliferative activity t
Autor:
Steve S. Choi, Jeongeun Hyun, Marzena Swiderska-Syn, Richard T. Premont, Youngmi Jung, Anna Mae Diehl, Bahar Salimian Rizi, George D. Dalton, Kuo Du, Gregory A. Michelotti, Eric Thelen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Cirrhosis results from accumulation of myofibroblasts derived from quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are depleted. Hedgehog signaling promotes transdifferentiation of HSCs by activatin
Autor:
Anna Mae Diehl, Gregory A. Michelotti, Cynthia D. Guy, Thiago A. Pereira, Mariana Verdelho Machado, Ann Marie Zavacki, Dawn Piercy, Leandi Krüger, Manal F. Abdelmalek, Brittany N. Bohinc, Herbert Pang, Guanhua Xie, Marzena Swiderska-Syn, Ayako Suzuki
Publikováno v:
Endocrinology
Thyroid hormone (TH) is important for tissue repair because it regulates cellular differentiation. Intrahepatic TH activity is controlled by both serum TH levels and hepatic deiodinases. TH substrate (T4) is converted into active hormone (T3) by deio
Publikováno v:
Hepatology. 61:98-107
Hedgehog (Hh) ligand production by ballooned hepatocytes drives nonalcoholic steatohepatitis (NASH) progression in mice. The NIDDK-sponsored PIVENS trial (NCT00063622) showed that vitamin E (VitE) improved NASH. We investigated whether VitE treatment