Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Raquel Maeso‐Díaz, George D. Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Tianyi Chen, Rajesh K. Dutta, Jessica H. Hartman, Joel N. Meyer, Anna Mae Diehl
Publikováno v:
Aging Cell. 21
Older age is a major risk factor for damage to many tissues, including liver. Aging undermines resiliency and impairs liver regeneration. The mechanisms whereby aging reduces resiliency are poorly understood. Hedgehog is a signaling pathway with crit
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 53:264-278
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of obesity-associated liver diseases and it has become the major cause of cirrhosis in the Western world. The high prevalence of NAFLD-associated advanced liver disease reflects both the
Publikováno v:
Journal of Hepatology. 68:550-562
Liver disease remains a leading cause of mortality worldwide despite recent successes in the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling an epidemic of chronic fatty liver disease for which there are cu
Autor:
Sihyung Wang, Jaewook Lee, Hee-Jae Cha, Ji Eun Kim, Youngmi Jung, Eun-Yi Moon, Chanbin Lee, Anna Mae Diehl, Jeongeun Hyun
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
SCIENTIFIC REPORTS(7)
Scientific Reports
SCIENTIFIC REPORTS(7)
Scientific Reports
The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway. HSC functions declined in a TB4
Autor:
Gregory A. Michelotti, Mark L. Jewell, Marzena Swiderska-Syn, Richard T. Premont, Anna Mae Diehl, Guanhua Xie, Wing-Kin Syn
Publikováno v:
Hepatology. 64:232-244
Introduction: Adult liver regeneration requires induction and suppression of proliferative activity in multiple types of liver cells. The mechanisms that orchestrate the global changes in gene expression that are required for proliferative activity t
Autor:
Steve S. Choi, Jeongeun Hyun, Marzena Swiderska-Syn, Richard T. Premont, Youngmi Jung, Anna Mae Diehl, Bahar Salimian Rizi, George D. Dalton, Kuo Du, Gregory A. Michelotti, Eric Thelen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Cirrhosis results from accumulation of myofibroblasts derived from quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are depleted. Hedgehog signaling promotes transdifferentiation of HSCs by activatin
Autor:
Anna Mae Diehl, Gregory A. Michelotti, Cynthia D. Guy, Thiago A. Pereira, Mariana Verdelho Machado, Ann Marie Zavacki, Dawn Piercy, Leandi Krüger, Manal F. Abdelmalek, Brittany N. Bohinc, Herbert Pang, Guanhua Xie, Marzena Swiderska-Syn, Ayako Suzuki
Publikováno v:
Endocrinology
Thyroid hormone (TH) is important for tissue repair because it regulates cellular differentiation. Intrahepatic TH activity is controlled by both serum TH levels and hepatic deiodinases. TH substrate (T4) is converted into active hormone (T3) by deio
Autor:
Mariana Verdelho Machado, Richard T. Premont, Guanhua Xie, Marzena Swiderska-Syn, Gregory A. Michelotti, Anna Mae Diehl, Mark L. Jewell
Publikováno v:
BMC Cell Biology, Vol 18, Iss 1, Pp 1-14 (2017)
BMC Cell Biology
BMC Cell Biology
Background Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage. Recovery from injury requires repair, an energy-expensive process that is coupled to energy availability at the cellular level.
Autor:
Anna Mae Diehl, Mariana Verdelho Machado, Marzena Swiderska-Syn, Wing-Kin Syn, Richard T. Premont, Gamze Karaca, Leandi Krüger, Guanhua Xie, Steve S. Choi, Gregory A. Michelotti
Publikováno v:
Gut. 63:1333-1344
Objective Smoothened (SMO), a coreceptor of the Hedgehog (Hh) pathway, promotes fibrogenic repair of chronic liver injury. We investigated the roles of SMO+ myofibroblast (MF) in liver regeneration by conditional deletion of SMO in α smooth muscle a
Autor:
Yuping Chen, Anna Mae Diehl, Richard T. Premont, Steve S. Choi, Guanhua Xie, Gregory A. Michelotti, Gamze Karaca, Leandi Krüger, Marzena Swiderska-Syn
Publikováno v:
Hepatology. 58:1801-1813
Liver repair involves phenotypic changes in hepatic stellate cells (HSC) and re-activation of morphogenic signaling pathways that modulate epithelial-to-mesenchymal/mesenchymal-to-epithelial transitions, such as Notch and Hedgehog (Hh). Hh stimulates