Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Aniella Abi-Gerges"'
Autor:
Aniella Abi-Gerges, Liliana R. V. Castro, Jérôme Leroy, Valérie Domergue, Grégoire Vandecasteele, Rodolphe Fischmeister
Publikováno v:
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2021, 150, pp.109-121. ⟨10.1016/j.yjmcc.2020.10.011⟩
Journal of Molecular and Cellular Cardiology, Elsevier, 2021, 150, pp.109-121. ⟨10.1016/j.yjmcc.2020.10.011⟩
International audience; Background In cardiomyocytes, phosphodiesterases (PDEs) type 3 and 4 are the predominant enzymes that degrade cAMP generated by β-adrenergic receptors (β-ARs), impacting notably the regulation of the L-type Ca2+ current (ICa
Autor:
Jérôme, Leroy, Wito, Richter, Delphine, Mika, Liliana R V, Castro, Aniella, Abi-Gerges, Moses, Xie, Colleen, Scheitrum, Florence, Lefebvre, Julia, Schittl, Philippe, Mateo, Ruth, Westenbroek, William A, Catterall, Flavien, Charpentier, Marco, Conti, Rodolphe, Fischmeister, Grégoire, Vandecasteele
Publikováno v:
The Journal of clinical investigation. 121(7)
β-Adrenergic receptors (β-ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca2+-induced Ca2+ release via phosphorylation of L-type Ca2+ channels (LTCCs) and ryanodine receptor 2. Multiple cyclic nucleot
Autor:
Florence Lefebvre, Grégoire Vandecasteele, Kathleen Horner, Aniella Abi-Gerges, Rodolphe Fischmeister, Dermot M.F. Cooper, Marco Conti, Francesca Rochais
Publikováno v:
Circulation Research
Circulation Research, American Heart Association, 2006, 98 (8), pp.1081-8. ⟨10.1161/01.RES.0000218493.09370.8e⟩
Circulation Research, American Heart Association, 2006, 98 (8), pp.1081-8. ⟨10.1161/01.RES.0000218493.09370.8e⟩
Compartmentation of cAMP is thought to generate the specificity of G s -coupled receptor action in cardiac myocytes, with phosphodiesterases (PDEs) playing a major role in this process by preventing cAMP diffusion. We tested this hypothesis in adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dc7783950681aacdc0ad0dc75f6078
https://www.hal.inserm.fr/inserm-00000047
https://www.hal.inserm.fr/inserm-00000047
Autor:
RODOLPHE FISCHMEISTER, Aniella Abi-Gerges, Francesca Rochais, Liliana R V Castro, Liliana Ribeiro Vivas Castro, Grégoire Vandecasteele
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Elsevier, 2005, 142 (2), pp.136-143. ⟨10.1016/j.cbpb.2005.04.012⟩
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Elsevier, 2005, 142 (2), pp.136-143. ⟨10.1016/j.cbpb.2005.04.012⟩
Biochemical studies have established the presence of a NO pathway in the heart, including sources of NO and various effectors. Several cardiac ion channels have been shown to be modified by NO, such as L-type Ca(2+), ATP-sensitive K(+), and pacemaker