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Autor:
Ewen MacDonald
Publikováno v:
Acta Pharmacologica et Toxicologica. 54:76-80
The pithed rat preparation was used to study the effects of copper (as cupric chloride) on the release and re-uptake of noradrenaline from sympathetic nerves. At the highest concentration which could be tested without failure of the preparation, ther
Publikováno v:
Acta Pharmacologica et Toxicologica. 51:309-320
Rats under pentobarbitone anaesthesia, pancuronium relaxation and artificial ventilation with constant volume, were given methacholine (MeCh) 4, 6, and 9 micrograms intravenously at 2 min. intervals; the rise in intratracheal pressure indicated bronc
Publikováno v:
Journal of Autonomic Pharmacology. 14:37-48
1. Power spectral analysis of the frequency of wave-forms of blood pressure and heart rate was used to characterize short-term fluctuations of these parameters in three strains of conscious Lyon rat, normotensive (LL and LN) and hypertensive LH. 2. A
Publikováno v:
Neuropharmacology. 31:777-782
The possibility that mu-opioid-induced tachycardia and bradycardia could be mediated by different subtypes of the mu-receptor was studied in conscious Sprague-Dawley rats. The selective mu-receptor agonist dermorphin and its analog, TAPS (Tyr-D-Arg-P
Publikováno v:
Journal of Cardiovascular Pharmacology. 19:541-545
To assess if the anti-beta-adrenergic effect and the bradycardia induced by amiodarone were mediated by thyroid hormone, we investigated these effects of amiodarone in euthyroid and hypothyroid rats. We studied control rats, thyroidectomized rats, co
Publikováno v:
Journal of Cardiovascular Pharmacology. 19:460-463
Hemodynamic responses to intravenous (i.v.) injection of DPMA [N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl] adenosine); PD 125,944], a potent adenosine agonist with a 32-fold selectivity for the adenosine-2 (A2) receptor subtype, were charact
Publikováno v:
Fundamental & Clinical Pharmacology. 6:67-73
The effects of quinpirole, a specific dopamine DA2 receptor agonist, on autonomic nervous control of heart rate, were studied in normotensive pithed rats, by analysing its action on the tachycardia and bradycardia evoked by electrical stimulation of
Autor:
Bhagavan S. Jandhyala, Jui Shah
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 19:89-94
SUMMARY 1. We have previously demonstrated that cerebroventricular administration of potassium chloride (KCI) solutions produces dose-dependent reductions in blood pressure and heart rate in anaesthetized rats and that these effects are significantly
Publikováno v:
General Pharmacology: The Vascular System. 23:131-139
1. The influence of the two antischistosomal drugs (+/-) praziquantel and (+/-) oxamniquine on PGI2 synthesis by the male rat thoracic aorta and day-20 pregnant rat myometrium in vitro was investigated using a rat platelet antiaggregatory bioassay me
Publikováno v:
European Journal of Pharmacology. 204:193-202
The effects of intracardiac infusions of adenosine on the changes in heart rate (HR), electrocardiogram (ECG) and arterial blood pressure (BP) induced by both vagal stimulation and exogenous acetylcholine (ACh) were studied in anesthetized rats. Aden