Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tarja Laitinen"'
Autor:
Morag Dixon, Pentti Tukiainen, Tarja Laitinen, Ulla Hodgson, Ville Pulkkinen, Juha Kere, Vesa Ollikainen, Marko Rehn, Kaisa Salmenkivi, Vuokko L. Kinnula, Päivi Lahermo, Myriam Peyrard-Janvid
Publikováno v:
The American Journal of Human Genetics. 79(1):149-154
We performed a genomewide scan in six multiplex families with familial idiopathic pulmonary fibrosis (IPF) who originated from southeastern Finland. The majority of the Finnish multiplex families were clustered in the region, and the population histo
Autor:
Erik Melén, Göran Pershagen, Sara Bruce, Josef Riedler, Cecilia M. Lindgren, Fredrik Nyberg, Gert Doekes, Roger Lauener, Marianne van Hage-Hamsten, Michael Kabesch, Annika Scheynius, Juha Kere, Magnus Wickman, Tarja Laitinen
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 171:1089-1095
Allergic diseases are influenced by both genes and environment. A 70-kb haplotype block in the G protein-coupled receptor for asthma susceptibility gene (GPR154; alias GPRA) on chromosome 7p was recently identified to influence susceptibility to asth
Autor:
Riitta Lahesmaa, Maritta Pykäläinen, Riikka Kinos, Juha Kere, Lauri A. Laitinen, Johannes Savolainen, Tarja Laitinen, N. Sirkkanen, Emmi Ylikoski
Publikováno v:
Clinical Experimental Allergy. 34:1049-1055
ummary Objective T-box expressed in T cells (T-bet) is a transcription factor regulating the commitment of T helper (Th) cells by driving the cells into the Th1 direction. Abnormal Th1/Th2 balance may lead to complex disorders like asthma or autoimmu
Autor:
Francesca Capon, Richard C. Trembath, Colin Veal, Michael Moser, Jonathan Barker, Sari Suomela, Ulpu Saarialho-Kere, Conxi Lázaro, Michael H. Allen, Tarja Laitinen, Kati Asumalahti, Samuli Ripatti, Outi Elomaa, Xavier Estivill, Giuseppe Novelli, Jan A. Marcusson, Hidemi Nakagawa, Juha Kere, Igor Vorechovsky, Rafael de Cid
Publikováno v:
Human Molecular Genetics. 11:589-597
PSORS1, near HLA-C, is the major genetic determinant of psoriasis. We present genetic and structural evidence suggesting a major role for the HCR gene at the PSORS1 locus. Genotyping of 419 families from six populations revealed that coding single-nu
Autor:
Tarja Laitinen, Paula Kauppi, Juha Kere, Kerstin Lindblad-Toh, Lauri A. Laitinen, John D. Rioux, Petteri Sevon, Hannu Toivonen, Anu Villapakkam, Thomas J. Hudson
Publikováno v:
Genomics. 77:35-42
We have analyzed a dense set of single-nucleotide polymorphisms (SNPs) and microsatellites spanning the T-helper cytokine gene cluster (interleukins 3, 4, 5, 9, and 13, interferon regulatory factor-1, colony-stimulating factor-2, and T-cell transcrip
Autor:
Pui-Yan Kwok, Antonio Cao, Jenna Putzel, Giuseppe Pilia, Irma Bauer-Sardiña, Patricia Taillon-Miller, Juha Kere, Tarja Laitinen, John P. Rice, Nancy L. Saccone
Publikováno v:
Nature Genetics. 25:324-328
Linkage disequilibrium (LD), or the non-random association of alleles, is poorly understood in the human genome1. Population genetic theory suggests that LD is determined by the age of the markers, population history, recombination rate, selection an
Publikováno v:
European Journal of Immunogenetics. 20:249-258
SUMMARY The polymorphism of Major Histocompatibility Complex (MHC) class II genes DRB, DQA, DQB, and DPA was studied by Taq I Restriction Fragment Length Polymorphism (RFLP) in recurrent spontaneous abortions (RSA). The study group consisted of 35 pr
Autor:
Lydia Pescollderungg, Cm Lindgren, Luciano Xumerle, Attilio Boner, Roberta Galavotti, P Kiviluoma, Tarja Laitinen, Pier Franco Pignatti, Giovanni Malerba, Elisabetta Trabetti, Juha Kere
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 37(1)
Summary Background Several genome scans have reported linkage of markers on chromosome 7p with asthma and related phenotypes in different populations. A fine mapping in Finnish and French-Canadian populations has associated the GPR154 gene (also know
Publikováno v:
BJOG: An International Journal of Obstetrics and Gynaecology. 104:1212-1214
HLA-G is a class I major histocompatibility complex gene that is expressed in cytotrophoblasts at the materno-fetal interface. It has been suggested that HLA-G could play a key role in materno-fetal immunological interactions during pregnancy. To inv
Autor:
Riikka Kinos, Tarja Laitinen, Mikko Hurme, Juha Kere, Maritta Kilpeläinen, Lauri A. Laitinen, Sanna Valkonen, Riitta Lahesmaa, Jussi Karjalainen, Pia Rydman, Markku S. Nieminen, Maritta Pykäläinen
Publikováno v:
The Journal of allergy and clinical immunology. 115(1)
Background Immune responses characterized by T H 2 type cells and IgE are important for the development of asthma and atopy. The transcription factors STAT6, GATA3, and STAT4 mediate the cytokine-induced development of naive CD4 + T cells into either