Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sherif Abdelhamed"'
Autor:
Jeffery M. Klco, Jing Ma, Xiaotu Ma, Ryan Hiltenbrand, Mary V. Relling, William E. Evans, Petri Pölönen, Paul E. Mead, Sonja Bendig, Steven M. Kornblau, Gang Wu, Selina M. Luger, Mark R. Litzow, Jacob M. Rowe, Stephen P. Hunger, Tamara Westover, Ti-Cheng Chang, Shunsuke Kimura, Jinghui Zhang, Elisabeth Paietta, Jun J. Yang, Alex Murison, Laura García-Prat, Torsten Haferlach, Ilaria Iacobucci, Chunxu Qu, Zhaohui Gu, Mignon L. Loh, Lindsey E. Montefiori, Marissa Rashkovan, Wenjian Yang, Marcus B. Valentine, Kathryn G. Roberts, Zhongshan Cheng, Beisi Xu, Victoria Wang, Jun Yin, Wendy Stock, Kirsten Dickerson, Cyrus M. Mehr, Claudia Haferlach, Adolfo A. Ferrando, Wolfgang Kern, Ching-Hon Pui, Kristine R. Crews, Andy G.X. Zeng, Sherif Abdelhamed, John E. Dick, Xiao-Long Chen, Anna Stengel, Charles G. Mullighan, Monique L. den Boer
Publikováno v:
Cancer Discovery. 11:2846-2867
Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T lymphoid, and stem cell markers driven by aberrant allele-specific deregu
Autor:
Shondra M. Pruett-Miller, Melvin Edward Thomas, Jason R. Schwartz, Guangchun Song, Jing Ma, Jeffery M. Klco, Michael Walsh, Sadie Miki Sakurada, Ryan Hiltenbrand, Sherif Abdelhamed
Publikováno v:
Leukemia
Pediatric myelodysplastic syndromes (MDS) are a heterogeneous disease group associated with impaired hematopoiesis, bone marrow hypocellularity, and frequently have deletions involving chromosome 7 (monosomy 7). We and others recently identified hete
Autor:
Marcus B. Valentine, Cyrus M. Mehr, Mary V. Relling, Kathryn G. Roberts, Jeffery M. Klco, Kirsten Dickerson, Zhongshan Cheng, Ilaria Iacobucci, Wenjian Yang, Jacob M. Rowe, Xiaotu Ma, Beisi Xu, Petri Pölönen, Tamara Westover, Jing Ma, Torsten Haferlach, Claudia Haferlach, Marissa Rashkovan, John E. Dick, Kristine R. Crews, Andy G.X. Zeng, Jun J. Yang, Chunxu Qu, Adolfo A. Ferrando, Mark R. Litzow, Sherif Abdelhamed, Wolfgang Kern, Wendy Stock, Shunsuke Kimura, Elisabeth Paietta, Mignon L. Loh, Zhaohui Gu, Ching-Hon Pui, Gang Wu, Victoria Wang, Selina M. Luger, Jun Yin, Steven M. Kornblau, Stephen P. Hunger, Laura García-Prat, William E. Evans, Alex Murison, Paul E. Mead, Sonja Bendig, Xiao-Long Chen, Anna Stengel, Jinghui Zhang, Charles G. Mullighan, Monique L. den Boer, Lindsey E. Montefiori, Ti-Cheng Chang, Ryan Hiltenbrand
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S269-S270
Context: Acute leukemias of ambiguous lineage (ALAL) pose significant diagnostic and therapeutic challenges due to lack of clarity surrounding their cellular origins and driving genomic alterations, as well as poor long-term response to conventional
Publikováno v:
Haematologica
Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell-intrinsic programs, hematopo
Autor:
Daniel L. Marks, John T. Butler, Sherif Abdelhamed, Eneida R. Nemecek, Ben Doron, Terzah M. Horton, Bill H. Chang, Phillip A. Wilmarth, Peter Kurre, Amber Halse
Publikováno v:
EMBO Rep
Progressive remodeling of the bone marrow microenvironment is recognized as an integral aspect of leukemogenesis. Expanding acute myeloid leukemia (AML) clones not only alter stroma composition, but also actively constrain hematopoiesis, representing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c176a5bcf097d70dec6440a5ff3619d5
https://europepmc.org/articles/PMC6607014/
https://europepmc.org/articles/PMC6607014/
Autor:
Peter Kurre, Ding-Wen Chen, Siqi Linsey Zhang, Theresa N Menna, Zhe Zhang, Jian-Meng Fan, Sherif Abdelhamed, Seul Jung
Publikováno v:
Blood. 136:36-36
Compartmental bone marrow (BM) inflammation has been linked to acute myeloid leukemia (AML) progression and hematopoietic dysfunction, yet the underlying mechanisms remain unclear. MicroRNAs (miRs) are capable of broadly deregulating cellular gene ex
Publikováno v:
Blood. 134:3730-3730
The remodeling of the bone marrow (BM) microenvironment that occurs along with the progressive spread of acute myeloid leukemia (AML) cells can be considered a constitutive aspect of leukemogenesis. To date most studies have focused on the functional
Autor:
Tamara Lamprecht, Aman Seth, Sherif Abdelhamed, Jeffery M. Klco, Ilaria Iacobucci, Ryan Hiltenbrand, Jonathan Miller, Charles G. Mullighan
Publikováno v:
Blood. 134:3775-3775
Chromosomal translocations are common in acute myeloid leukemia (AML), causing gene fusions that encode oncogenic proteins. The NUP98 gene participates in chromosomal rearrangements with over 30 fusion partners and comprises 6-10% of de novo cases of
Publikováno v:
Leukemia
Successive adaptation of the bone marrow (BM) from homeostatic hematopoietic microenvironment to a self-reinforcing niche is an integral aspect of leukemogenesis. Yet, the cellular mechanisms underlying these functional alterations remain to be defin