Zobrazeno 1 - 5
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pro vyhledávání: '"Jeffrey E. DeClue"'
Publikováno v:
Proceedings of the National Academy of Sciences. 90:5539-5543
The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively regulate GTP-Ras by accelerating its conversion to inactive GDP-Ras. In schwannoma cell lines f
Publikováno v:
Proceedings of the National Academy of Sciences. 88:9914-9918
The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1 that is homologous to the ras GTPase-activating protein (GAP) encodes a similar GTPase-stimula
Autor:
Jeffrey E. DeClue, D R Lowy, Ke Zhang, R. A. Blanchard, P. Martin, Alex G. Papageorge, J. C. Stone
Publikováno v:
Molecular and Cellular Biology. 11:3132-3138
A series of v-rasH effector domain mutants were analyzed for their ability to transform rat 2 cells at either low or high temperatures. Three mutants were found to be significantly temperature sensitive: Ile-36 changed to Leu, Ser-39 changed to Cys (
Autor:
Jeffrey E. DeClue, Ke Zhang, William C. Vass, Alex G. Papageorge, Frank McCormick, Douglas R. Lowy
Publikováno v:
Nature. 346:754-756
The ras genes are required for normal cell growth and mediate transformation by oncogenes encoding protein tyrosine kinases. Normal ras can transform cells in vitro and in vivo, but mutationally activated ras does so much more efficiently, and highly
Overexpression of the full-length GTPase-activating protein (GAP) has recently been shown to suppress c-ras transformation of NIH 3T3 cells but not v-ras transformation (36). Here, we show that focus formation induced by c-src was inhibited by approx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9770ff3faf43506b7a378165654164
https://europepmc.org/articles/PMC360064/
https://europepmc.org/articles/PMC360064/