Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Liron Bar-Peled"'
Autor:
Tatiani B. Lima, A.F.Z. Nascimento, Juliana Helena Costa Smetana, David M. Sabatini, Germanna Lima Righetto, Kuang Shen, Gustavo Fernando Mercaldi, Ana L S Silva, Liron Bar-Peled, Nadia Rasheed, Fabio C. Gozzo, Ricardo Aparicio
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 9, Iss 9, Pp 1589-1602 (2019)
FEBS Open Bio, Vol 9, Iss 9, Pp 1589-1602 (2019)
Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X‐interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here, we pres
Autor:
Roberto Zoncu, David M. Sabatini, William C. Comb, Bernardo L. Sabatini, Lynne Chantranupong, Rachel L. Wolfson, Molly Plovanich, Zhi-Yang Tsun, Shuyu Wang, Choah Kim, Christoph Straub, Kuang Shen, Tony D. Jones, Liron Bar-Peled, Timothy C. Wang, Gregory A. Wyant, Jiwon Park, Elizabeth D. Yuan
Publikováno v:
Science. 347:188-194
Sensing amino acids at the lysosome The mTORC1 protein kinase is a complex of proteins that functions to regulate growth and metabolism. Activity of mTORC1 is sensitive to the abundance of amino acids, but how the sensing of amino acids is coupled to
Autor:
David M. Sabatini, Liron Bar-Peled
Publikováno v:
PMC
The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promot
Autor:
Choah Kim, Liron Bar-Peled, Timothy C. Wang, Eric Spooner, Lynne Chantranupong, David M. Sabatini, Zhi-Yang Tsun, Roberto Zoncu
Publikováno v:
PMC
The mTORC1 kinase is a master growth regulator that senses numerous environmental cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino acid sufficiency by promoting the translocation of mTORC1 to the lysosomal surface, i
Autor:
Brian C. Grabiner, Matthew Meyerson, Walter W. Chen, Kathleen Ottina, Scott L. Carter, David M. Sabatini, Eric D. Spear, Lynne Chantranupong, Liron Bar-Peled, Andrew D. Cherniack
Publikováno v:
Science. 340:1100-1106
Limiting mTORC1 The mTORC1 protein kinase complex has important functions linking metabolism to cell growth and its functions are disrupted in common diseases, including cancer and diabetes. Bar-Peled et al. (p. 1100 ; see the Perspective by Shaw ) d
Publikováno v:
Cell. 150(6):1196-1208
The mTOR Complex 1 (mTORC1) pathway promotes cell growth in response to a diverse set of cues, including growth factors as well as energy and amino acid levels. Amino acids signal through the Rag GTPases to promote the translocation of mTORC1 to the
Publikováno v:
PMC
The mTOR complex 1 (mTORC1) protein kinase is a master growth regulator that is stimulated by amino acids. Amino acids activate the Rag guanosine triphosphatases (GTPases), which promote the translocation of mTORC1 to the lysosomal surface, the site
Autor:
Yasemin Sancak, Roberto Zoncu, Shigeyuki Nada, Liron Bar-Peled, David M. Sabatini, Andrew L. Markhard
Publikováno v:
PMC
The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids, and its activity is often deregulated in disease. The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by prom
Publikováno v:
PMC
Cell Reports, Vol 12, Iss 9, Pp 1445-1455 (2015)
Cell Reports, Vol 12, Iss 9, Pp 1445-1455 (2015)
mTORC1 controls key processes that regulate cell growth, including mRNA translation, ribosome biogenesis, and autophagy. Environmental amino acids activate mTORC1 by promoting its recruitment to the cytosolic surface of the lysosome, where its kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c633f84658ed9d6a1a7eec972b2d36
http://hdl.handle.net/1721.1/109108
http://hdl.handle.net/1721.1/109108
Autor:
Carson C. Thoreen, David M. Sabatini, Robert A. Lindquist, Timothy R. Peterson, Liron Bar-Peled, Yoav D. Shaul, Yasemin Sancak
The multiprotein mTORC1 protein kinase complex is the central component of a pathway that promotes growth in response to insulin, energy levels, and amino acids and is deregulated in common cancers. We find that the Rag proteins—a family of four re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15435a5a49b6e16d3581e391fe93ea7c
https://europepmc.org/articles/PMC2475333/
https://europepmc.org/articles/PMC2475333/