Zobrazeno 1 - 10
of 22
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Trabszo, Christof, Ramms, Bastian, Chopra, Pradeep, Lüllmann-Rauch, Renate, Stroobants, Stijn, Sproß, Jens, Jeschke, Anke, Schinke, Thorsten, Boons, Geert-Jan, Esko, Jeffrey D., Lübke, Torben, Dierks, Thomas
Publikováno v:
Biochemical Journal; Sep2020, Vol. 477 Issue 17, p3433-3451, 19p
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 239:788-793
A series of dicationic amphiphilic drugs, most of them immunomodulatory agents, are known to induce generalised lysosomal storage of sulphated glycosaminoglycans (GAGs) in rats and in cultured cells of several species including man. The present study
Publikováno v:
General Pharmacology: The Vascular System. 27:1317-1324
1. Certain compounds (e.g., the immunomodulator tilorone and congeners) are able to induce lysosomal storage of sulphated glycosaminoglycans (GAG), thus, producing cytological and biochemical alterations reminiscent of the inherited mucopolysaccharid
Publikováno v:
Pharmacology & Toxicology. 79:109-113
The immunomodulatory drug tilorone (2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one) and several congeners are known to disturb the lysosomal degradation of sulphated glycosaminoglycans and thereby induce lysosomal storage of glycosaminoglycans in cultu
Publikováno v:
Toxicology. 110:27-37
The antimalarial agents quinacrine and chloroquine are well known as potent inducers of lysosomal storage of polar lipids (lipidosis) in cell culture and in vivo. In previous experiments on cultured fibroblasts, chloroquine was shown to additionally
Publikováno v:
Virchows Archiv B Cell Pathology Including Molecular Pathology. 60:99-104
Several di-cationic amphiphilic compounds are known to cause lysosomal accumulation of sulfated glycosaminoglycans (sGAG) in intact rats and in cultured rat fibroblasts. The purpose of the present investigation was to examine whether this drug side e
Autor:
Renate Lüllmann-Rauch, M. Ziegenhagen
Publikováno v:
Histochemistry. 95:263-268
The purpose of the present investigation was to examine whether or not a di-cationic amphiphilic compound that is known (1) to be accumulated in lysosomes and (2) to form insoluble complexes with sulfated glycosaminoglycans (sGAG) in vitro, is able t
Publikováno v:
Xenobiotica. 20:1259-1267
1. Drug accumulation without a concomitant elevation of blood level may occur if the capacity of the tissue to bind drug increases during chronic treatment. 2. This special type of accumulation is found with cationic-amphiphilic drugs, which induce t
The immunomodulatory agent tilorone {2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one} and congeners are potent inducers of lysosomal storage of sulphated glycosaminoglycans (GAGs) in animals and cultured fibroblasts of animals and man. All potent induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a31651ace076e154fb33a6ce1926a2
https://europepmc.org/articles/PMC1217205/
https://europepmc.org/articles/PMC1217205/
Publikováno v:
Biochemical pharmacology. 49(9)
This investigation deals with a drug side-effect. The immunomodulatory drug tilorone (2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one) and congeners induce lysosomal storage of sulphated glycosaminoglycans (GAGs) in animals and in cultured cells. At hig