Zobrazeno 1 - 10
of 21
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Trabszo, Christof, Ramms, Bastian, Chopra, Pradeep, Lüllmann-Rauch, Renate, Stroobants, Stijn, Sproß, Jens, Jeschke, Anke, Schinke, Thorsten, Boons, Geert-Jan, Esko, Jeffrey, Lübke, Torben, Dierks, Thomas, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery
Publikováno v:
Biochemical Journal, 477(17). Portland Press Ltd.
Biochem J
Biochem J
Mucopolysaccharidoses comprise a group of rare metabolic diseases, in which the lysosomal degradation of glycosaminoglycans (GAGs) is impaired due to genetically inherited defects of lysosomal enzymes involved in GAG catabolism. The resulting intraly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea602d018494379fb323a0b52cb4d810
https://doi.org/10.1042/bcj20200546
https://doi.org/10.1042/bcj20200546
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 239:788-793
A series of dicationic amphiphilic drugs, most of them immunomodulatory agents, are known to induce generalised lysosomal storage of sulphated glycosaminoglycans (GAGs) in rats and in cultured cells of several species including man. The present study
Publikováno v:
General Pharmacology: The Vascular System. 27:1317-1324
1. Certain compounds (e.g., the immunomodulator tilorone and congeners) are able to induce lysosomal storage of sulphated glycosaminoglycans (GAG), thus, producing cytological and biochemical alterations reminiscent of the inherited mucopolysaccharid
Publikováno v:
Pharmacology & Toxicology. 79:109-113
The immunomodulatory drug tilorone (2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one) and several congeners are known to disturb the lysosomal degradation of sulphated glycosaminoglycans and thereby induce lysosomal storage of glycosaminoglycans in cultu
Publikováno v:
Virchows Archiv B Cell Pathology Including Molecular Pathology. 60:99-104
Several di-cationic amphiphilic compounds are known to cause lysosomal accumulation of sulfated glycosaminoglycans (sGAG) in intact rats and in cultured rat fibroblasts. The purpose of the present investigation was to examine whether this drug side e
Autor:
Renate Lüllmann-Rauch, M. Ziegenhagen
Publikováno v:
Histochemistry. 95:263-268
The purpose of the present investigation was to examine whether or not a di-cationic amphiphilic compound that is known (1) to be accumulated in lysosomes and (2) to form insoluble complexes with sulfated glycosaminoglycans (sGAG) in vitro, is able t
Publikováno v:
Archives of Toxicology. 64:291-298
The purpose of the present investigation was to establish a cell culture system suitable for demonstrating the drug-induced lysosomal storage of sulfated glycosaminoglycans (GAGs). This is a drug side-effect which was previously studied in animals tr
Publikováno v:
Xenobiotica. 20:1259-1267
1. Drug accumulation without a concomitant elevation of blood level may occur if the capacity of the tissue to bind drug increases during chronic treatment. 2. This special type of accumulation is found with cationic-amphiphilic drugs, which induce t
Publikováno v:
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 50(4-6)
Summary Dicationic amphiphilic drugs such as the immunomodulator tilorone {2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one} are accumulated in lysosomes and disturb the degradation of sulphated glycosaminoglycans (GAGs) thus leading to generalized lyso
The immunomodulatory agent tilorone {2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one} and congeners are potent inducers of lysosomal storage of sulphated glycosaminoglycans (GAGs) in animals and cultured fibroblasts of animals and man. All potent induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a31651ace076e154fb33a6ce1926a2
https://europepmc.org/articles/PMC1217205/
https://europepmc.org/articles/PMC1217205/