Zobrazeno 1 - 5
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pro vyhledávání: '"Jane A. Cox"'
Autor:
Patrick Schloss, Christoph M. Schuster, Jane A. Cox, Heinrich Betz, Bertram Schmitt, Andreas Ultsch
Publikováno v:
Science (New York, N.Y.). 254(5028)
Insects and other invertebrates use glutamate as a neurotransmitter in the central nervous system and at the neuromuscular junction. A complementary DNA from Drosophila melanogaster, designated DGluR-II, has been isolated that encodes a distant homol
Publikováno v:
Neuron. 4(6)
Using neurotoxicity and inositol phosphate release as criteria for receptor expression, we report the differential expression of excitatory amino acid receptor subtypes in cerebellar granule cells grown in serum-free media containing either high (25
Publikováno v:
Brain Research. 499:267-272
Results of the present report show that cerebellar neurons in primary culture are resistant to glutamate concentrations as high as 5 mM in the presence of glucose and Mg2+, but sensitive to glutamate concentrations lower than 35 microM when the neuro
Publikováno v:
Annals of the New York Academy of Sciences. 568
Our results demonstrated that the neurotoxicity of glutamate and closely related agonists was mediated by the NMDA receptor in rat cerebellar granule cells. Evidence was presented to support our hypothesis that the pivotal event in the transition of
Publikováno v:
Brain research. 499(2)
l -Glutamate neurotoxicity at the N-methyl- d -aspartate (NMDA) receptor was characterized in cultured cerebellar granule cells. When deprived of glucose for 40 min, these cells were killed by 20–60 μM l -glutamate. However, the neurons were resis