Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Davide Trotti"'
Autor:
Piera Pasinelli, Silvia Bonanno, Davide Trotti, Loqman A. Mohamed, Shashirekha S. Markandaiah
Publikováno v:
Exp Neurol
In amyotrophic lateral sclerosis (ALS), upregulation in expression and activity of the ABC transporter P-glycoprotein (P-gp) driven by disease advancement progressively reduces CNS penetration and efficacy of the ALS drug, riluzole. Post-mortem spina
Autor:
Gabriel R. Linares, Justin K. Ichida, Yingxiao Shi, Brandon B Ge, Yichen Li, Jacob Komberg, R. Jeroen Pasterkamp, Davide Trotti, Valerie Hennes, Leonard H. van den Berg, Nicole Koutsodendris, Jason A. Chen, Kaitlin P. Sandor, Vamshidhar R. Vangoor, Louise Menendez, Amy R. Nelson, Michael E. Ward, Tze-Yuan Cheng, Yaoming Wang, Phillip E. Woolwine, Wen-Hsuan Chang, Ketharini Senthilkumar, Kim A. Staats, Mickey Huang, Carina Seah, Alice Zhang, Chris Grunseich, Esther Y. Son, Eric Hendricks, Michael J. Cowan, Paul R. August, Kassandra Kisler, Shih Jong J. Lee, Marcelo P. Coba, Shu Ting Hung, Shaoyu Lin, Brent Wilkinson, N. Wisniewski, Berislav V. Zlokovic, Tohru Sugawara, T. Grant Belgard, Victor Hanson-Smith, Xinmei Wen
Publikováno v:
Nature Medicine, 24(3), 313. Nature Publishing Group
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7b18c3fd3677e0457e409e74f97ed0
https://dspace.library.uu.nl/handle/1874/364200
https://dspace.library.uu.nl/handle/1874/364200
Autor:
Lauren Taylor Rosenblum, Angelo C. Lepore, Davide Trotti, Piera Pasinelli, Shashirekha Shamamandri-Markandaiah, Biswarup Ghosh, Emily Foran
Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f43ebc502a99c4b16eb824a7325d820
https://europepmc.org/articles/PMC5433801/
https://europepmc.org/articles/PMC5433801/
Autor:
Lauren Taylor Rosenblum, Davide Trotti
Publikováno v:
Advances in Neurobiology ISBN: 9783319557670
Amyotrophic lateral sclerosis (ALS) is a rapid and fatal neurodegenerative disease, primarily affecting upper and lower motor neurons. It is an extremely heterogeneous disease in both cause and symptom development, and its mechanisms of pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1368de5f48a1f0b4a7c07d52d84a72
https://europepmc.org/articles/PMC6668619/
https://europepmc.org/articles/PMC6668619/
Publikováno v:
Glia. 62:1241-1253
EAAT2 is a predominantly astroglial glutamate transporter responsible for the majority of synaptic glutamate clearance in the mammalian central nervous system (CNS). Its dysfunction has been linked with many neurological disorders, including amyotrop
Autor:
Davide Trotti, Emily Foran
Publikováno v:
Antioxidants & Redox Signaling. 11:1587-1602
Responsible for the majority of excitatory activity in the central nervous system (CNS), glutamate interacts with a range of specific receptor and transporter systems to establish a functional synapse. Excessive stimulation of glutamate receptors cau
Autor:
Stuart L. Gibb, William Boston-Howes, Piera Pasinelli, Zeno Scotto Lavina, Robert H. Brown, Davide Trotti, Stefano Gustincich
Publikováno v:
Journal of Biological Chemistry. 282:32480-32490
EAAT2 (excitatory amino acid transporter 2) is a high affinity, Na+-dependent glutamate transporter of glial origin that is essential for the clearance of synaptically released glutamate and prevention of excitotoxicity. During the course of human am
Autor:
Piera Pasinelli, Niels C. Danbolt, Masashi Aoki, Matthias A. Hediger, Urs V. Berger, Robert H. Brown, Davide Trotti
Publikováno v:
Journal of Biological Chemistry. 276:576-582
We have investigated the functional impact of a naturally occurring mutation of the human glutamate transporter GLT1 (EAAT2), which had been detected in a patient with sporadic amyotrophic lateral sclerosis. The mutation involves a substitution of th
Autor:
Andrea Volterra, Claudia Verderio, Silvia Coco, Michela Matteoli, Jeffrey D. Rothstein, Davide Trotti
Publikováno v:
European Journal of Neuroscience. 9:1902-1910
It has been postulated for several years that the high affinity neuronal glutamate uptake system plays a role in clearing glutamate from the synaptic cleft. Four different glutamate transporter subtypes are now identified, the major neuronal one bein
Autor:
Daniela Rossi, Davide Trotti, Giorgio Racagni, Andrea Volterra, Niels C. Danbolt, Line M. Levy, Ola Gjesdal
Publikováno v:
ResearcherID
The reuptake of glutamate in neurons and astrocytes terminates excitatory signals and prevents the persistence of excitotoxic levels of glutamate in the synaptic cleft. This process is inhibited by oxygen radicals and hydrogen peroxide (H2O2). Here w