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pro vyhledávání: '"Lone H. Landsy"'
Autor:
Brian Lauritzen, Birgitte M. Viuff, Shari A. Price, Lone H. Landsy, Jens Lykkesfeldt, Hermann Pelzer, Lykke Boysen, James T. Raymond
Publikováno v:
Toxicologic Pathology. 48:570-585
Administration of human protein–based drugs to animals often leads to formation of antidrug antibodies (ADAs) that may form circulating immune complexes (CICs) with the dosed protein. Circulating immune complexes can activate and bind complement (c
Autor:
Brian Lauritzen, Lykke Boysen, Lone H. Landsy, Jens Lykkesfeldt, Birgitte M. Viuff, James T. Raymond, Shari A. Price
Publikováno v:
Journal of Immunotoxicology, Vol 16, Iss 1, Pp 191-200 (2019)
Boysen, L, Viuff, B M, Landsy, L H, Price, S A, Raymond, J T, Lykkesfeldt, J & Lauritzen, B 2019, ' Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin : Evaluation of dose, frequency, and biomarkers ', Journal of Immunotoxicology, vol. 16, no. 1, pp. 191-200 . https://doi.org/10.1080/1547691X.2019.1680776
Boysen, L, Viuff, B M, Landsy, L H, Price, S A, Raymond, J T, Lykkesfeldt, J & Lauritzen, B 2019, ' Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin : Evaluation of dose, frequency, and biomarkers ', Journal of Immunotoxicology, vol. 16, no. 1, pp. 191-200 . https://doi.org/10.1080/1547691X.2019.1680776
In preclinical toxicity studies, species-foreign proteins administered to animals frequently leads to formation of anti-drug antibodies (ADA). Such antibodies may form circulating immune complexes (CIC) with the administered protein. These CIC can ac