Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Takeharu Kunieda"'
Publikováno v:
Cancers, Vol 14, Iss 19, p 4890 (2022)
CLICs are the dimorphic protein present in both soluble and membrane fractions. As an integral membrane protein, CLICs potentially possess ion channel activity. However, it is not fully clarified what kinds of roles CLICs play in physiological and pa
Externí odkaz:
https://doaj.org/article/0da6ff26f9564dd580f09e1c1a3aa467
Autor:
Shirabe Matsumoto, Seiji Shigekawa, Hideaki Watanabe, Saya Ozaki, Yoshihiro Ohtsuka, Hajime Yano, Akihiro Inoue, Takanori Ohnishi, Riko Kitazawa, Yawara Nakamura, Junya Tanaka, Takeharu Kunieda, Yonehiro Kanemura, Masahiro Nishikawa, Daisuke Yamashita, Satoshi Suehiro
Publikováno v:
World Neurosurgery. 153:e76-e95
Background We previously reported that glioma stemlike cells (GSCs) exist in the area of the tumor periphery showing no gadolinium enhancement on magnetic resonance imaging. In the present work, we analyzed glucose metabolism to investigate whether l
Autor:
Hajime Yano, Hideaki Watanabe, Riko Kitazawa, Akihiro Inoue, Satoshi Suehiro, Saya Ozaki, Shiro Ohue, Masahiro Nishikawa, Shirabe Matsumoto, Takeharu Kunieda, Shohei Kohno, Takanori Ohnishi, Seiji Shigekawa, Yonehiro Kanemura, Junya Tanaka, Yawara Nakamura
Publikováno v:
Cancer Medicine, Vol 10, Iss 6, Pp 2013-2025 (2021)
Cancer Medicine
Cancer Medicine
Antiangiogenic therapy with bevacizumab (Bev), a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is a common treatment for recurrent glioblastoma (GBM), but its survival benefit is limited. Resistance to Bev is thought to be
Autor:
Mie Kurata, Saya Ozaki, Shiro Ohue, Hideaki Watanabe, Akihiro Inoue, Riko Kitazawa, Satoshi Suehiro, Shohei Kohno, Takeharu Kunieda, Takanori Ohnishi, Shirabe Matsumoto, Mana Fukushima, Masahiro Nishikawa, Seiji Shigekawa
Publikováno v:
Neurosurgical Review. 44:587-597
Glioblastoma multiforme (GBM) is largely due to glioma stem cells (GSCs) that escape from total resection of gadolinium (Gd)-enhanced tumor on MRI. The aim of this study is to identify the imaging requirements for maximum resection of GBM with infilt
Autor:
Satoshi Suehiro, Akihiro Inoue, Takanori Ohnishi, Takeharu Kunieda, Shohei Kohno, Masahiro Nishikawa, Shiro Ohue, Junya Tanaka, Daisuke Yamashita
Publikováno v:
Journal of Neurosurgery. 129:1416-1428
OBJECTIVEHigh invasiveness of malignant gliomas frequently causes early local recurrence of the tumor, resulting in extremely poor outcome. To control such recurrence, novel therapies targeted toward infiltrating glioma cells around the tumor border
Autor:
Soniya Bastola, Victoria L. Flanary, Riki Kawaguchi, Daisuke Yamashita, Hackney, Shinobu Yamaguchi, Ichiro Nakano, Satoshi Suehiro, Dolores Hambardzumyan, Marat S. Pavlyukov, Sonomura K, Myriam Gorospe, Takaaki Sato, Harley I. Kornblum, Saya Ozaki, Nakano Ma, David K. Crossman, Toru Kondo, Rachel Munk, Takeharu Kunieda
SummaryThe rise in aging population worldwide is increasing death from cancer, including glioblastoma. Here, we explore the impact of brain aging on glioma tumorigenesis. We find that glioblastoma in older patients and older mice displayed reduced ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886b97ed0048d05dd0d297d509b3de05
https://doi.org/10.1101/2020.10.10.334748
https://doi.org/10.1101/2020.10.10.334748
Autor:
Hajime Yano, Satoshi Suehiro, Riko Kitazawa, Yoshihiro Ohtsuka, Shirabe Matsumoto, Masahiro Nishikawa, Hideaki Watanabe, Takeharu Kunieda, Seiji Shigekawa, Shohei Kohno, Takanori Ohnishi, Yonehiro Kanemura, Junya Tanaka, Saya Ozaki, Shiro Ohue, Akihiro Inoue
Background The poor prognosis of glioblastoma multiforme (GBM) is primarily due to highly invasive and highly migratory glioma stem-like cells (GSCs) in tumors. Upon GBM recurrence or progression, the highly invasive phenotype of GSCs changes to a le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5fea354ca5147a388b3fbd90fa6bcd1
https://doi.org/10.21203/rs.3.rs-72809/v1
https://doi.org/10.21203/rs.3.rs-72809/v1
Autor:
Galal A. Elsayed, Qin Chen, Harley I. Kornblum, Soniya Bastola, Takeharu Kunieda, Hee Jin Cho, Daisuke Yamashita, Gustavo Chagoya, Moaaz Abdelrashid, Yoshihiro Ohtsuka, Chaoxi Li, Toru Kondo, Do Hyun Nam, Svetlana Komarova, Saya Ozaki, Ichiro Nakano
Publikováno v:
Neuro-oncology Advances
BackgroundGlioblastoma remains highly lethal due to its inevitable recurrence. This recurrence is found locally in most cases, indicating that post-surgical tumor-initiating cells (TICs) accumulate at tumor edge. These edge TICs then generate recurre
Autor:
Mohammed E. Choudhury, Akihiro Umakoshi, Shota Ohsumi, Shirabe Matsumoto, Kana Taguchi, Takeharu Kunieda, Naoki Abe, Yutaro Sumida, Toshihiro Yorozuya, Junya Tanaka, Jun Kuwabara, Yuji Watanabe, Eika Usa, Hajime Yano, Hisaaki Takahashi
Publikováno v:
Biochemical and Biophysical Research Communications. 496:542-548
CD200 mediates immunosuppression in immune cells that express its receptor, CD200R. There are two CD200 variants; truncated CD200 that lacks the part of N-terminal sequence necessary for CD200R binding (CD200S) and full-length CD200 (CD200L). We esta
Autor:
Yoshihiro Ohtsuka, Yonehiro Kanemura, Riko Kitazawa, Akihiro Inoue, Hajime Yano, Takanori Ohnishi, Satoshi Suehiro, Takeharu Kunieda, Masahiro Nishikawa, Hideaki Watanabe, Seiji Shigekawa, Saya Ozaki, Shiro Ohue, Junya Tanaka, Shohei Kohno
Publikováno v:
Translational Oncology, Vol 14, Iss 8, Pp 101137-(2021)
Translational Oncology
Translational Oncology
Highlights • CD44, upregulated by HIF-1α under 1%O2, induces highly invasive phenotype GSCs. • HIF-2α-activated OPN under 5%O2 promotes less-invasive/proliferative type GSCs. • CD44 and OPN knockdowns inhibit in vitro/vivo GSCs invasion and p