Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Xinyi Jiang"'
Autor:
Chen Chen, Weiqiang Jing, Yu Chen, Ganyu Wang, Mohnad Abdalla, Lin Gao, Maosen Han, Chongdeng Shi, Anning Li, Peng Sun, Xin Jiang, Zhenmei Yang, Shengchang Zhang, Jing Zhang, Chunwei Tang, Ying Liu, Rui Zhang, Fengbo Xu, Baixiang Dong, Xueen Li, Minglu Liu, Bangming Qiang, Yanhua Sun, Xia Wei, Jun Li, Quanyin Hu, Xinyi Jiang
Publikováno v:
Science Translational Medicine. 14
Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin around the initial resected lesion due to postsurgery res
Autor:
Gerald A. Grant, Sergio Fitch, Christine Wang, Viola Caretti, Sauradeep Sinha, Fan Yang, Xinyi Jiang, Michelle Monje, Christy Wilson, Anitha Ponnuswami
Publikováno v:
Acta Biomater
Brain tumors exhibit vast genotypic and phenotypic diversity depending on patient age and anatomical location. Hydrogels hold great promise as 3D in vitro models for studying brain tumor biology and drug screening, yet previous studies were limited t
Autor:
Sauradeep Sinha, Christy Wilson, Gerald A. Grant, Christine Wang, Sergio Fitch, Fan Yang, Luke Murphy, Xinyi Jiang
Publikováno v:
Tissue Eng Part A
Cancer progression is known to be accompanied by changes in tissue stiffness. Previous studies have primarily employed immortalized cell lines and 2D hydrogel substrates, which do not recapitulate the 3D tumor niche. How matrix stiffness affects pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98635a758e4009299c33ce08557233f
https://europepmc.org/articles/PMC7984937/
https://europepmc.org/articles/PMC7984937/
Autor:
Aihua Gong, Weiqiang Jing, Yingchao Liu, Jing Zhang, Xinyi Jiang, Wei Du, Jibiao Wu, Chen Chen, Xueyang Huang, Anning Li, Ying Liu, Rui Zhang, Shengchang Zhang, Peng Sun
Publikováno v:
Nature nanotechnology. 16(5)
Immunotherapies have revolutionized intervention strategies for many primary cancers, but have not improved the outcomes of glioblastoma multiforme (GBM), which remains one of the most lethal malignant cerebral tumours. Here we present an injectable
Publikováno v:
Theranostics
Hypoxia, a hallmark of malignant tumors, often correlates with increasing tumor aggressiveness and poor treatment outcomes. Due to a lack of vasculature, effective drug delivery to hypoxic tumor regions remains challenging. Signaling through the chem
Autor:
Christy Wilson, Christine Wang, Sergio Fitch, Gerald A. Grant, Xinyi Jiang, Fan Yang, Jianfeng Li
Glioblastoma multiforme (GBM) is one of the most intractable of human cancers, principally because of the highly infiltrative nature of these neoplasms. Tracking and eradicating infiltrating GBM cells and tumor microsatellites is of utmost importance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee99ef8918dc9b3c4ba79e4599881f2
https://europepmc.org/articles/PMC5137687/
https://europepmc.org/articles/PMC5137687/
Publikováno v:
Journal of biomedical materials research. Part A. 105(3)
Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with median survival of 12 months. To improve clinical outcomes, it is critical to develop in vitro models that support GBM proliferation and invasion for deciphering tu
Autor:
Xinyi Jiang, Hongliang Xin, Yanzuo Chen, Jijin Gu, Zhang Wei, Xianyi Sha, Jieqi Luo, Xiaoling Fang, Liangcen Chen, Xiaoqing Ren
Publikováno v:
International Journal of Pharmaceutics. 402:238-247
The aim of this work was to investigate the anti-tumor effect of paclitaxel (PTX)-loaded methoxy poly(ethylene glycol)-poly(ɛ-caprolactone) nanoparticles (MPEG-NP/PTX) against glioblastoma multiforme (GBM). MPEG-NP/PTX was prepared by the emulsion a
Publikováno v:
Biomaterials. 33(32)
Therapeutic effect of glioma is often limited due to low permeability of delivery systems across the Blood-Brain Barrier (BBB) and poor penetration into the tumor tissue. In order to overcome the two barriers, we proposed Angiopep-conjugated PEG-PCL
Autor:
Kitki Law, Xinyi Jiang, Ye Jiang, Xiao Wang, Liangcen Chen, Xiaoling Fang, Jijin Gu, Yanzuo Chen, Xianyi Sha, Hongliang Xin
Publikováno v:
International journal of pharmaceutics. 420(2)
The aim of this study was to investigate the antitumor effect of paclitaxel (PTX)-loaded poly(ethylene glycol)-poly(trimethylene carbonate) (MPEG-PTMC) nanoparticles (NP) against gioblastoma multiforme (GMB). PTX-loaded NP (NP/PTX) were prepared with