Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Hui K. Gan"'
Autor:
Juliana Gomez, Zammam Areeb, Sarah F. Stuart, Hong P. T. Nguyen, Lucia Paradiso, Ahmad Zulkifli, Sonakshi Madan, Vijay Rajagopal, Magdalene K. Montgomery, Hui K. Gan, Andrew M. Scott, Jordan Jones, Andrew H. Kaye, Andrew P. Morokoff, Rodney B. Luwor
Publikováno v:
Cancers, Vol 13, Iss 6, p 1198 (2021)
Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiological conditions that lead to ER stress. However, the key upstream receptor tyrosine kinase that regulates RCN1 express
Externí odkaz:
https://doaj.org/article/4e7ab66647e94fccb77f168917810ebd
Autor:
Benjamin Y Kong, Hao-Wen Sim, Elizabeth H Barnes, Anna K Nowak, Elizabeth J Hovey, Rosalind Jeffree, Rosemary Harrup, Jonathon Parkinson, Hui K Gan, Mark B Pinkham, Sonia Yip, Merryn Hall, Emily Tu, Candace Carter, Eng-Siew Koh, Zarnie Lwin, Anthony Dowling, John S Simes, Craig Gedye
IntroductionGlioblastoma (GBM) is the most common malignant primary central nervous system cancer in adults. The objective of the Multi-Arm GlioblastoMa Australasia (MAGMA) trial is to test hypotheses in real world setting to improve survival of peop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97516e26ac47154b148b622c9b9fc25
Autor:
Louis B. Nabors, David A. Reardon, John Simes, Lisa Roberts-Rapp, Ho-Jin Lee, Nicholas Butowski, Tobias Walbert, Andrew B. Lassman, Helen Wheeler, Priya Kumthekar, Andrew M. Scott, Peter Ansell, Tom Mikkelsen, Marta Penas-Prado, Kyriakos P. Papadopoulos, Martin J. van den Bent, Earle Bain, Zarnie Lwin, Erica Gomez, David Maag, Ryan Merrell, Hui K Gan, Hao Xiong, Kyle D. Holen
Publikováno v:
Cancer Chemotherapy & Pharmacology, 80(6), 1209-1217. Springer-Verlag
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Purpose Patients with recurrent glioblastoma (rGBM) have a poor prognosis. Epidermal growth factor receptor (EGFR) gene amplification is present in ~ 50% of glioblastomas (GBMs). Depatuxizumab mafodotin (depatux-m), formerly ABT-414, is an antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff65c6833473b7cdb380bda35882ca5
Autor:
Frederick S. Varn, Kevin C. Johnson, Jan Martinek, Jason T. Huse, MacLean P. Nasrallah, Pieter Wesseling, Lee A.D. Cooper, Tathiane M. Malta, Taylor E. Wade, Thais S. Sabedot, Daniel Brat, Peter V. Gould, Adelheid Wöehrer, Kenneth Aldape, Azzam Ismail, Santhosh K. Sivajothi, Floris P. Barthel, Hoon Kim, Emre Kocakavuk, Nazia Ahmed, Kieron White, Indrani Datta, Hyo-Eun Moon, Steven Pollock, Christine Goldfarb, Ga-Hyun Lee, Luciano Garofano, Kevin J. Anderson, Djamel Nehar-Belaid, Jill S. Barnholtz-Sloan, Spyridon Bakas, Annette T. Byrne, Fulvio D’Angelo, Hui K. Gan, Mustafa Khasraw, Simona Migliozzi, D. Ryan Ormond, Sun Ha Paek, Erwin G. Van Meir, Annemiek M.E. Walenkamp, Colin Watts, Tobias Weiss, Michael Weller, Karolina Palucka, Lucy F. Stead, Laila M. Poisson, Houtan Noushmehr, Antonio Iavarone, Roel G.W. Verhaak, Kristin D. Alfaro, Samirkumar B. Amin, David M. Ashley, Christoph Bock, Andrew Brodbelt, Ketan R. Bulsara, Ana Valeria Castro, Jennifer M. Connelly, Joseph F. Costello, John F. de Groot, Gaetano Finocchiaro, Pim J. French, Anna Golebiewska, Ann C. Hau, Chibo Hong, Craig Horbinski, Kasthuri S. Kannan, Mathilde CM. Kouwenhoven, Anna Lasorella, Peter S. LaViolette, Keith L. Ligon, Allison K. Lowman, Shwetal Mehta, Hrvoje Miletic, Annette M. Molinaro, Ho Keung Ng, Simone P. Niclou, Johanna M. Niers, Joanna J. Phillips, Raul Rabadan, Ganesh Rao, Guido Reifenberger, Nader Sanai, Susan C. Short, Peter Sillevis Smitt, Andrew E. Sloan, Marion Smits, James M. Snyder, Hiromichi Suzuki, Ghazaleh Tabatabai, Georgette Tanner, William H. Tomaszewski, Michael Wells, Bart A. Westerman, Helen Wheeler, Jichun Xie, W.K. Alfred Yung, Gelareh Zadeh, Junfei Zhao, Roel GW. Verhaak
Publikováno v:
Cell, 185(12), 2184-2199.e16. Cell Press
Cell
Cell, vol 185, iss 12
The GLASS Consortium 2022, ' Glioma progression is shaped by genetic evolution and microenvironment interactions ', Cell, vol. 185, no. 12, pp. 2184-2199.e16 . https://doi.org/10.1016/j.cell.2022.04.038
Cell, 185(12), 2184-2199.e16. CELL PRESS
Cell
Cell, vol 185, iss 12
The GLASS Consortium 2022, ' Glioma progression is shaped by genetic evolution and microenvironment interactions ', Cell, vol. 185, no. 12, pp. 2184-2199.e16 . https://doi.org/10.1016/j.cell.2022.04.038
Cell, 185(12), 2184-2199.e16. CELL PRESS
The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36aa8231290284197e37208bfab4dbba
https://research.vumc.nl/en/publications/312bbb0a-1328-4405-bfbe-cce4f07b8a67
https://research.vumc.nl/en/publications/312bbb0a-1328-4405-bfbe-cce4f07b8a67
Autor:
Lakshmi Nayak, Nathan Standifer, Jorg Dietrich, Jennifer L. Clarke, Gavin P. Dunn, Michael Lim, Timothy Cloughesy, Hui K. Gan, Elizabeth Flagg, Elizabeth George, Sarah Gaffey, Julia Hayden, Christina Holcroft, Patrick Y. Wen, Mary Macri, Andrew J. Park, Toni Ricciardi, Aileen Ryan, Paul Schwarzenberger, Ralph Venhaus, Melissa de los Reyes, Nicholas M. Durham, Todd Creasy, Raymond Y. Huang, Thomas Kaley, David A. Reardon
Publikováno v:
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 12
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 12
Purpose: PD-L1 is upregulated in glioblastoma and supports immunosuppression. We evaluated PD-L1 blockade with durvalumab among glioblastoma cohorts and investigated potential biomarkers. Patients and Methods: MGMT unmethylated newly diagnosed patien
Autor:
Craig Gedye, David Lorente, Isabelle Dussault, Michael Weller, Morris D. Groves, Hui K Gan, Laureen S. Ojalvo, David A. Reardon, Andrew M. Scott, Kathryn Kolibaba, David Vicente, Chee Khoon Lee, Macarena I. de la Fuente, Mustafa Khasraw, Carole Gourmelon, Christoph Helwig
Publikováno v:
Neuro-oncology Advances
Background For patients with recurrent glioblastoma (rGBM), there are few options following treatment failure with radiotherapy plus temozolomide. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of
Autor:
Hong P. T. Nguyen, Ahmad Zulkifli, Zammam Areeb, Sarah F. Stuart, Jordan Jones, Lucia Paradiso, Andrew H. Kaye, Vijay Rajagopal, Sonakshi Madan, Hui K Gan, Magdalene K. Montgomery, Juliana Gomez, Andrew P. Morokoff, Andrew M. Scott, Rodney B. Luwor
Publikováno v:
Cancers
Volume 13
Issue 6
Cancers, Vol 13, Iss 1198, p 1198 (2021)
Volume 13
Issue 6
Cancers, Vol 13, Iss 1198, p 1198 (2021)
Simple Summary A key molecule, EGFRvIII has been shown to provide several growth advantages for brain tumors. However, we have found a new mechanism in which the EGFRvIII provides increased survival to brain cancer cells when under sub-optimal condit
Autor:
Peter Ansell, Lisa Roberts-Rapp, Priya Kumthekar, Ho-Jin Lee, Marta Penas-Prado, Louis B. Nabors, David A. Reardon, Hao Xiong, Earle Bain, Erica Gomez, David Maag, Kyriakos P. Papadopoulos, Martin J. van den Bent, Tobias Walbert, Nicholas Butowski, Andrew B. Lassman, Ryan Merrell, Zarnie Lwin, Hui K Gan, Kyle D. Holen, Helen Wheeler, Andrew M. Scott, Tom Mikkelsen, John Simes
Publikováno v:
Neuro-Oncology, 21(1), 106-114. Oxford University Press
Neuro-Oncology
Neuro-Oncology
Background Patients with glioblastoma (GBM) have a dismal prognosis. Nearly all will relapse with no clear standard of care for recurrent disease (rGBM). Approximately 50% of patients have tumors harboring epidermal growth factor receptor (EGFR) ampl
Autor:
Rosemary Harrup, Anthony Dowling, Adam Cooper, Tracey Dunlop, John Simes, Elizabeth H Barnes, Katharine Cuff, Zarnie Lwin, Benjamin Y. Kong, Elizabeth Hovey, Hui K Gan, Merryn Hall, Anna K. Nowak, Rosalind L. Jeffree, Emily Tu, Peter Lau, Sonia Yip, Diana Andrew, Eng-Siew Koh, Eric Khoo, Anthony Linton, Jonathon Parkinson, Craig Gedye, Hao-Wen Sim
Publikováno v:
Neuro-Oncology. 23:vi193-vi194
BACKGROUND Survival outcomes for patients with newly diagnosed glioblastoma have not changed significantly since the introduction of concurrent temozolomide with post-surgical radiation followed by adjuvant temozolomide. METHODS Multi-Arm Glioblastom
Autor:
Umbreen Hafeez, Siddharth Menon, Lawrence Cher, Hui K Gan, Sagun Parakh, Adithya Balasubramanian, Ashray Gunjur
Publikováno v:
Neuro-oncology Advances
Background Improving outcomes of patients with glioblastoma (GBM) represents a significant challenge in neuro-oncology. We undertook a systematic review of key parameters of phase II and III trials in GBM to identify and quantify the impact of trial