Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Morris, D."'
Autor:
Monica Loghin, W. K. Alfred Yung, Stefania Maraka, Marta Penas-Prado, Charles A. Conrad, John de Groot, Erik P. Sulman, Kenneth Aldape, Barbara O’Brien, Ivo W. Tremont-Lukats, Mark R. Gilbert, Kenneth R. Hess, Morris D. Groves, Aaron Mammoser, Vinay K. Puduvalli, Isaac Melguizo-Gavilanes
Publikováno v:
Cancer. 125:424-433
BACKGROUND: Repurposed memantine, mefloquine, and metformin have putative anticancer activity. The objective of this phase 1 study was to determine the maximum tolerated doses (MTDs) of combinations of these agents with temozolomide (TMZ). METHODS: A
Autor:
Michael A. Vogelbaum, Farshad Nassiri, Clark C. Chen, Frank Tufaro, Shirley Ong, Adam M. Sonabend, Rohan Ramakrishna, Priya Kumthekar, Frederick Lang, Morris D. Groves, Barry Watkins, Gelareh Zadeh, Howard Colman, Carin Bidwell, Robert Aiken, Simon Khagi, Joanna Peterkin, Timothy F. Cloughesy, Laura Agensky, Mariza Daras
Publikováno v:
Neuro Oncol
BACKGROUND DNX-2401 (tasadenoturev) is a replication-competent, tumor-selective, oncolytic adenovirus. Phase I studies in adults with recurrent glioblastoma (rGBM) have demonstrated safety and encouraging clinical activity. A Phase II open-label, dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9729a46d32e41f44d380b45a4f07fb2f
https://europepmc.org/articles/PMC6847955/
https://europepmc.org/articles/PMC6847955/
Publikováno v:
Cancer. 125:1385-1386
Autor:
Ava B. Plummer, Morris D. Groves
Publikováno v:
CONTINUUM: Lifelong Learning in Neurology. 18:421-425
Outcomes for patients with glioblastoma have improved with the addition of temozolomide (TMZ) chemotherapy to radiation therapy followed by adjuvant TMZ for up to 1 year. Patients often wish to continue chemotherapy after the standard 1-year course.
Autor:
Charles A. Conrad, Eric L. Chang, W. K. Alfred Yung, Kathy Hunter, John de Groot, Mark R. Gilbert, Morris D. Groves, Vinay K. Puduvalli, Howard Colman, S.Y. Woo, Kenneth R. Hess, Anita Mahajan, Victor A. Levin, Pierre Giglio, Javier Gonzalez
Publikováno v:
Neuro-Oncology
External beam radiation therapy (XRT) with concomitant temozolomide and 6 cycles of adjuvant temozolomide (5/28-day schedule) improves survival in patients with newly diagnosed glioblastoma compared with XRT alone. Studies suggest that dose-dense tem
Autor:
Kenneth Aldape, Vinay K. Puduvalli, Aaron Gerald Mammoser, John de Groot, Barbara O’Brien, Marta Penas-Prado, Kenneth R. Hess, Monica Loghin, Ivo W. Tremont-Lukats, Isaac Melguizo-Gavilanes, Stefania Maraka, Morris D. Groves, W. K. Alfred Yung, Erik P. Sulman, Charles A. Conrad, Mark R. Gilbert
Publikováno v:
Journal of Clinical Oncology. 36:2044-2044
2044Background: Repurposing non-cancer drugs may represent a new source of novel therapies for glioblastoma (GBM). Memantine, mefloquine, and metformin have putative anticancer activity potentially...
Autor:
Christina A. Meyers, Victor A. Levin, W. K. Alfred Yung, Vivien Liu, Charles A. Conrad, Morris D. Groves, V. K. Puduvalli, Kathy Hunter, Kenneth R. Hess, Mark R. Gilbert
Publikováno v:
British Journal of Cancer
Background: Because of the poor outcomes for patients with recurrent glioblastoma multiforme (GBM), and some laboratory and clinical evidence of efficacy using interferon in GBM, we assessed the toxicity and efficacy of temozolomide (TMZ) combined wi
Autor:
Sandra Ictech, Charles A. Conrad, Edward F. Jackson, Victor A. Levin, Vinay K. Puduvalli, John de Groot, Pierre Giglio, Sigmund Hsu, Howard Colman, Kenneth R. Hess, Morris D. Groves, Srikanth Mahankali, Melesa G. Ritterhouse, Mark R. Gilbert, W. K. Alfred Yung
Publikováno v:
Neuro-Oncology. 10:216-222
Glioblastoma multiforme (GBM) is associated with significant morbidity and a disproportionately high rate of mortality. For patients with newly diagnosed GBM, chemoradiation therapy followed by adjuvant treatment with temozolomide provides a survival
Autor:
Alfred Rademaker, Kenneth Aldape, Morris D. Groves, Charles A. Conrad, Mark R. Gilbert, Nina Paleologos, Sean Grimm, J. F. De Groot, Jeffrey Raizer, Monica Loghin, Pierre Giglio, Vinay K. Puduvalli, W. K. A. Yung, Jethro Hu, Jeremy Rudnick, Nicholas A. Vick, Brian Vaillant, Surasak Phuphanich, Diane Liu, Ryan Merrell, Marc C. Chamberlain, Ying Yuan, Ivo W. Tremont-Lukats
Publikováno v:
Journal of neuro-oncology. 126(1)
Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor is generally worse than methylated MGMT tumors, as temozolomide (TMZ) response is limited. How to better treat patients with unmethylated MGMT is unknown. We pe
Autor:
B. Berkey, Minesh P. Mehta, Christopher J. Schultz, Diana F. Nelson, Sandra Vermeulen, W. K. Alfred Yung, Howard Colman, Morris D. Groves, Moshe H. Maor
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 66:818-824
Purpose: The aim of this study was to determine whether recombinant human interferon β-1a (rhIFN-β), when given after radiation therapy, improves survival in glioblastoma. Methods and Materials: After surgery, 109 patients with newly diagnosed supr