Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Philippe Bois"'
Publikováno v:
Human Molecular Genetics. 6:1565-1571
Human minisatellite MS32 (D1S8) shows instability both in the germline and, at much lower levels, in somatic DNA. To investigate factors that influence somatic and germline mutation, large cosmid-based constructs containing MS32 were introduced into
Autor:
Andrew Collick, Wolf Reik, J. Drew, Alec J. Jeffreys, Philippe Bois, J. Penberth, Jeni Luckett, F. Scaerou
Publikováno v:
Scopus-Elsevier
Various sequences in the mammalian genomes are unstable. One class of sequence arrangement is long inverted repeats, which are known to be unstable in bacteria and yeast. While in mammals some evidence suggests that short inverted repeats (
Publikováno v:
Genomics. 80(1)
Minisatellites provide very informative systems for analyzing processes of tandem repeat DNA turnover in humans. The mouse genome also contains authentic minisatellites, but none has yet been found to show high levels of instability. Indirect evidenc
Autor:
Alec J. Jeffreys, Philippe Bois
Publikováno v:
Cellular and molecular life sciences : CMLS. 55(12)
Tandem-repeat DNA actively turns over in the genome by a variety of poorly understood dynamic mechanisms. Minisatellites, a class of tandem repeats, have been shown to cause disease by influencing gene expression, modifying coding sequences within ge
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781489900913
Evermore sophisticated tests are need to study germline toxicology. The gene conversion-based systems developed in Leicester and in the USA are steps in the right direction, but a lot of validation both in vivo and in vitro is required. Transgenic te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33fc066344c2d725de7a09e553d18a30
https://doi.org/10.1007/978-1-4899-0089-0_14
https://doi.org/10.1007/978-1-4899-0089-0_14
Autor:
Yuri E. Dubrova, David L. Neil, John Murray, Jane Yardley, Jérǒme Buard, Philippe Bois, Caroline R. H. Hollies, Rita Neumann, Alec J. Jeffreys, Andrew Collick, Celia A. May, Keiji Tamaki, John D.H. Stead
Publikováno v:
Electrophoresis. 18(9)
Minisatellites provide not only the basis for DNA fingerprinting and DNA profiling but also extremely informative systems for analysing processes of tandem repeat turnover in the human genome. Minisatellite instability appears to involve distinct mut
Autor:
Maxine J. Allen, Alec J. Jeffreys, S.C. Barton, M. A. Surani, Philippe Bois, M.L. Norris, Andrew Collick
Publikováno v:
Scopus-Elsevier
Tandem repeat loci such as minisatellites and trinucleotide repeats frequently show instability. We have investigated mutation at human minisatellite MS32 (locus D1S8) transferred to transgenic mice. Three lines of hemizygous transgenic mice were stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7038ee4fb464a245f57d10f6f2b278
https://europepmc.org/articles/PMC395540/
https://europepmc.org/articles/PMC395540/