Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jun-ichi Iga"'
Autor:
Hiroaki Mori, Yuta Yoshino, Jun-ichi Iga, Shinichiro Ochi, Yu Funahashi, Kiyohiro Yamazaki, Hiroshi Kumon, Yuki Ozaki, Shu-ichi Ueno
Publikováno v:
Journal of Alzheimer's Disease. :1-12
Background: We explored the gene expression levels in the brain of 3xTg-AD model mice to elucidate the molecular pathological changes from the early to end stages of Alzheimer’s disease (AD). Objective: We re-analyzed our previously published micro
Autor:
Hideaki Shimizu, Takaaki Mori, Taku Yoshida, Ayumi Tachibana, Tomoki Ozaki, Yuta Yoshino, Shinichiro Ochi, Naomi Sonobe, Teruhisa Matsumoto, Kenjiro Komori, Jun‐ichi Iga, Toshiharu Ninomiya, Shu‐ichi Ueno, Manabu Ikeda
Publikováno v:
Psychogeriatrics. 22:631-641
The number of dementia patients is increasing worldwide, especially in Japan, which has the world's highest ageing population. The increase in the number of older people with dementia is a medical and socioeconomic problem that needs to be prevented,
Autor:
Mariko Ueno, Yuta Yoshino, Hiroaki Mori, Yu Funahashi, Hiroshi Kumon, Shinichiro Ochi, Tomoki Ozaki, Ayumi Tachibana, Taku Yoshida, Hideaki Shimizu, Takaaki Mori, Jun-ichi Iga, Shu-ichi Ueno
Publikováno v:
Journal of Alzheimer's Disease. 87:863-871
Background: Late-onset Alzheimer’s disease (LOAD) is a complex disease in which neuroinflammation plays an important pathophysiological role, and exposure to neurotoxic substrates such as aldehydes may contribute. Blood mRNA expression levels of ne
Autor:
Hideaki Shimizu, Yuta Yoshino, Yuki Ozaki, Taku Yoshida, Hiroshi Kumon, Shu-ichi Ueno, Jun-ichi Iga, Takaaki Mori, Shinichiro Ochi, Kiyohiro Yamazaki, Hiroaki Mori, Ayumi Tachibana, Yu Funahashi
Publikováno v:
Journal of Alzheimer's Disease
Background: Cyclin-dependent kinase inhibitor 2A (CDKN2A) is an important gene in cellular senescence and aging. Objective: This study assessed the utility of blood CDKN2A mRNA expression levels and methylation status as a potential biomarker for agi
Publikováno v:
Journal of Alzheimer's disease reports. 6(1)
Background: Dementia in patients with late-life mood disorders is clinically important. Objective: We aimed to investigate the prevalence of dementia in patients with late-life major depressive disorder (MDD) or bipolar disorder (BD) and to clarify t
Autor:
Hiroaki Mori, Masahiro Nomoto, Jun-ichi Iga, Mariko Ueno, Hiroshi Kumon, Masahiro Nagai, Yu Funahashi, Shu-ichi Ueno, Kiyohiro Yamazaki, Takaaki Mori, Yuki Ozaki, Shinichiro Ochi, Yuta Yoshino
Publikováno v:
Journal of Alzheimer's Disease
Background: Phosphatidylinositol-binding clathrin assembly protein (PICALM) is a validated genetic risk factor for late-onset Alzheimer’s disease (AD) and is associated with other neurodegenerative diseases. However, PICALM expression in the blood
Autor:
Tomoko Sao, Yoko Mori, Yuta Yoshino, Jun-ichi Iga, Yuki Ozaki, Taku Yoshida, Takaaki Mori, Shinichiro Ochi, Shu-ichi Ueno, Kiyohiro Yamazaki
Publikováno v:
Journal of Alzheimer's Disease. 64:1275-1284
Background Triggering receptor expressed on myeloid cells 2 (TREM2) activates the innate immune system, promotes phagocytosis by microglia, and is associated with Alzheimer's disease (AD). The possible role of a related molecule, TREM1, in AD remains
Autor:
Yoko Mori, Shu-ichi Ueno, Yuta Yoshino, Yuki Ozaki, Taku Yoshida, Kiyohiro Yamazaki, Tomoko Sao, Takaaki Mori, Jun-ichi Iga, Shinichiro Ochi
Publikováno v:
Journal of Alzheimer's Disease. 58:687-694
Microglial dysfunction and inflammation have recently been shown to be related to the development of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase (INPP5D) functions broadly as a negative regulator of immune signaling, and its locus
Autor:
Shu-ichi Ueno, Jun-ichi Iga, Kiyohiro Yamazaki, Taku Yoshida, Yuki Ozaki, Yuta Yoshino, Tomoko Sao, Yu Funahashi, Takaaki Mori
Publikováno v:
Journal of Alzheimer's Disease. 54:1349-1357
Despite the continuing debate about the amyloid hypothesis in Alzheimer's disease (AD), the precise pathogenesis is still unclear. Mixed pathology is common and multiple different protein aggregates are seen in human postmortem brains. Aggregates con
Autor:
Keiichi Kikuchi, Naomi Sonobe, Taku Yoshida, Masao Miyagawa, Takaaki Mori, Teruhisa Matsumoto, Jun-ichi Iga, Shu-ichi Ueno, Yuta Yoshino, Hideaki Shimizu, Teruhito Mochizuki
Publikováno v:
International Journal of Geriatric Psychiatry. 32:407-413
Objective Impairment of visual perception frequently occurs in Alzheimer's disease (AD) and can cause severe constraints in daily activities. The nonverbal Raven's Colored Progressive Matrices (RCPM) test consists of sets A, AB, and B and is easily p