Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gil Atzmon"'
Autor:
Vera Gorbunova, Joydeep Mitra, Tina Gao, M. Reza Jabalameli, Almut Nebel, Matthias Laudes, Paul D. Robbins, Siegfried Görg, Quanwei Zhang, Alan R. Shuldiner, Valerio Napolioni, Kenny Ye, Nir Barzilai, Gil Atzmon, Warren C. Ladiges, Sofiya Milman, Yousin Suh, Guillermo G. Torres, Nha Nguyen, Zhengdong Zhang, Michael D. Greicius, Zhen Wang, Jhih Rong Lin, Jan Vijg, Patrick Sin-Chan, Andre Franke, Laura J. Niedernhofer
Publikováno v:
Nature Aging. 1:783-794
Extreme longevity in humans has a strong genetic component, but whether this involves genetic variation in the same longevity pathways as found in model organisms is unclear. Using whole-exome sequences of a large cohort of Ashkenazi Jewish centenari
Autor:
Brenda Gonzalez, Archana Tare, Seungjin Ryu, Simon C. Johnson, Gil Atzmon, Nir Barzilai, Matt Kaeberlein, Yousin Suh
Publikováno v:
GeroScience.
Mitochondrial dysfunction is a well-known contributor to aging and age-related diseases. The precise mechanisms through which mitochondria impact human lifespan, however, remain unclear. We hypothesize that humans with exceptional longevity harbor ra
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Robert P. Adelson, Yun Freudenberg-Hua, Alison Goate, Nir Barzilai, Gil Atzmon, Peter Davies, Jeremy Koppel, Brian Fulton-Howard, Marc L. Gordon
Publikováno v:
Neurobiol Aging
To evaluate how age and apolipoprotein E-e4 (APOE4) status interact with APOE-independent polygenic risk score (PRSnon-APOE), we estimated PRSnon-APOE in superagers (age ≥ 90 years, N = 346), 89− controls (age 60–89, N = 2930), and Alzheimer's
Autor:
Gil Atzmon, Nir Barzilai, P. Eline Slagboom, Fernando Macian, Ignacio Guerrero-Ros, Andrea B. Maier, Yotam Raz
Publikováno v:
Journal of Gerontology: Medical Sciences, 72(9), 1201-1206
Raz, Y, Guerrero-Ros, I, Maier, A, Slagboom, P E, Atzmon, G, Barzilai, N & Macian, F 2017, ' Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity ', The journals of gerontology. Series A : Biological sciences and medical sciences, vol. 72, no. 9, pp. 1201-1206 . https://doi.org/10.1093/gerona/glx020
The journals of gerontology. Series A : Biological sciences and medical sciences, 72(9), 1201-1206. Oxford University Press
Raz, Y, Guerrero-Ros, I, Maier, A, Slagboom, P E, Atzmon, G, Barzilai, N & Macian, F 2017, ' Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity ', The journals of gerontology. Series A : Biological sciences and medical sciences, vol. 72, no. 9, pp. 1201-1206 . https://doi.org/10.1093/gerona/glx020
The journals of gerontology. Series A : Biological sciences and medical sciences, 72(9), 1201-1206. Oxford University Press
As with many other tissues and organs, the immune system is also affected by age. Immunosenescence is characterized by a decreased ability of immune cells to mount a productive response upon exposure to new antigens. Several studies have reported tha
Autor:
Francesco Villa, Anastasia Gurinovich, Gil Atzmon, Annibale Alessandro Puca, Thomas T. Perls, Harold Bae, Aldi T. Kraja, Stacy L. Andersen, Paola Sebastiani, Nir Barzilai, Danny Ben-Avraham, Alberto Malovini
Publikováno v:
The Journals of Gerontology: Series A. 72:1453-1464
The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators. To address these issues, we established a consortium of four studies of extreme longevit
Publikováno v:
Gerontology. 66(4)
Over the past century, the life expectancy in industrialized countries has rapidly risen by over 30 years due to improvements in standards of medical care, sanitation, and lifestyle. Estimation of life expectancy has traditionally been viewed through
Autor:
Stacy L. Andersen, Annibale Alessandro Puca, Paola Sebastiani, Nir Barzilai, Gil Atzmon, Anastasia Gurinovich
Publikováno v:
J Gerontol A Biol Sci Med Sci
APOE is a well-studied gene with multiple effects on aging and longevity. The gene has three alleles: e2, e3, and e4, whose frequencies vary by ethnicity. While the e2 is associated with healthy cognitive aging, the e4 allele is associated with Alzhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcd92a6b2349e50eb1cd41ded403fea
http://hdl.handle.net/11386/4740655
http://hdl.handle.net/11386/4740655
Autor:
Takashi Sasaki, Francesco Villa, Paola Sebastiani, Gil Atzmon, Harold Bae, Nir Barzilai, Kaare Christensen, Marianne Nygaard, Yasumichi Arai, Thomas T. Perls, Lene Christiansen, Nobuyoshi Hirose, Annibale Alessandro Puca, Anastasia Gurinovich, Stacy L. Andersen, Benjamin Sweigart
Publikováno v:
Sebastiani, P, Gurinovich, A, Nygaard, M, Sasaki, T, Sweigart, B, Bae, H, Andersen, S L, Villa, F, Atzmon, G, Christensen, K, Arai, Y, Barzilai, N, Puca, A, Christiansen, L, Hirose, N & Perls, T T 2019, ' APOE Alleles and Extreme Human Longevity ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 74, no. 1, pp. 44–51 . https://doi.org/10.1093/gerona/gly174
We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a8a0a84b2a589d71dcec32a8cda603
https://europepmc.org/articles/PMC6298189/
https://europepmc.org/articles/PMC6298189/
Publikováno v:
Aging & Mental Health. 20:930-939
Favorable attitudes, emotions, personality characteristics, and self-rated health have been associated with successful aging in late life. However, less is known regarding these constructs and their relationships to mental health outcomes in the olde