Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Seppo Heinonen"'
Autor:
Miira M. Klemetti, Anni Timonen, Tea Kaartokallio, Eero Kajantie, Jukka Uotila, Hannele Laivuori, Seppo Heinonen, Juha Kere, Anneli Pouta, Päivi Lakkisto, Katja Kivinen
Publikováno v:
Hypertension. 64:172-177
Preeclampsia is a serious and phenotypically heterogeneous vascular pregnancy disorder. Heme oxygenase-1 (HO-1) is a stress response enzyme that may protect the maternal endothelium and facilitate adequate metabolic adaptation to pregnancy by its ant
Autor:
Eero Kajantie, Miira M. Klemetti, Katja Kivinen, Juha Kere, Seppo Heinonen, Tea Kaartokallio, Hannele Laivuori, Tiina Karppanen, Anne Cathrine Staff, Anneli Pouta
Publikováno v:
BMC Genetics
Background: Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3'UTR polymorphism of the Regulator of G-protein signaling 2 g
Autor:
Anneli Pouta, Jingwen Wang, Hannele Laivuori, Hong Jiao, Juha Kere, Eero Kajantie, Tea Kaartokallio, Paul Gerdhem, Seppo Heinonen, Katja Kivinen
Publikováno v:
Scientific Reports
Pre-eclampsia is a common pregnancy disorder that is a major cause for maternal and perinatal mortality and morbidity. Variants predisposing to pre-eclampsia might be under negative evolutionary selection that is likely to keep their population frequ
Autor:
Seppo Helisalmi, Susan Iivonen, Seppo Heinonen, Marja-Liisa Eloranta, Mikko Hiltunen, Jaana Laasanen
Publikováno v:
Fetal Diagnosis and Therapy. 23:36-40
Objective: To determine whether genetic variability in the intron 1 region of the gamma 2 actin gene (enteric type) contributes to the development of obstetric complications. Study Design: The study involved 57 obstetric cholestasis and 133 preeclamp
Publikováno v:
Gynecologic and Obstetric Investigation. 61:124-127
Background: Preeclampsia is a common hereditary disease with unclear aetiology and various genetic and environmental components. We wanted to determine whether genetic variability in the gene encoding plasma cell membrane glycoprotein-1 (PC-1) contri
Publikováno v:
MHR: Basic science of reproductive medicine. 11:437-440
We determined whether polymorphisms in the promoter region of the tumour necrosis factor alpha (TNF-alpha) gene contributes to differences in susceptibility to develop pre-eclampsia. The study involved 133 pre-eclamptic and 115 healthy pregnant women
Autor:
Mia Pirskanen, Fareeza Akbar, Tomi-Pekka Tuomainen, Seppo Heinonen, Jukka T. Salonen, Pekka Uimari
Publikováno v:
MHR: Basic science of reproductive medicine. 11:73-77
Association between pre-eclampsia (PEE1) and the dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes, which play a role in the regulation of nitric oxide synthesis and release, was studied. In a case –control study design single nucleotide
Autor:
Sari Toivonen, Leea Keski-Nisula, Kari Punnonen, Seppo Helisalmi, Seppo Heinonen, Eeva-Liisa Romppanen
Publikováno v:
Fetal Diagnosis and Therapy. 20:508-511
Objective: To study whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) affects individual susceptibility to the development of placental abruption during pregnancy. Methods: One hundred and sixteen pregnant wome
Autor:
Fareeza Faisel, Jukka T. Salonen, Kari Punnonen, Mikko Hiltunen, Eeva-Liisa Romppanen, Jaana Laasanen, Seppo Heinonen, Seppo Helisalmi
Publikováno v:
European Journal of Human Genetics. 12:187-191
This study determines whether genetic variability in the gene-encoding factor V contributes to differences in pre-eclampsia susceptibility. Allele and genotype frequencies of three single-nucleotide polymorphisms (SNPs) in the factor V gene leading t
Autor:
Fareeza Faisel, Seppo Helisalmi, Jukka T. Salonen, Seppo Heinonen, Mikko Hiltunen, E eva-Liisa Romppanen, Kari Punnonen
Publikováno v:
Journal of Reproductive Immunology. 60:61-70
We have determined whether genetic variability in the gene encoding interleukin 1 receptor antagonist ( IL1Ra ) contributes to individual differences in susceptibility to the development of preeclampsia. The study involved 133 preeclamptic and 112 he