Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Todd, Stephen"'
Autor:
Proitsi P; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Department of Psychiatry, State Key Laboratory of Brain and Cognitive Sciences, and Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong. Electronic address: petroula.proitsi@kcl.ac.uk., Lupton MK; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Velayudhan L; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Hunter G; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK., Newhouse S; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Lin K; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Fogh I; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Tsolaki M; Memory and Dementia Centre, Aristotle University of Thessaloniki, Thessaloniki, Greece., Daniilidou M; Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece., Pritchard M; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Craig D; Ageing group, Centre for Public Health, School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland, UK., Todd S; Ageing group, Centre for Public Health, School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland, UK., Johnston JA; Ageing group, Centre for Public Health, School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland, UK., McGuinness B; Ageing group, Centre for Public Health, School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland, UK., Kloszewska I; Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz, Poland., Soininen H; Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland., Mecocci P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Vellas B; Department of Internal and Geriatrics Medicine, INSERM U 1027, Gerontopole, Hôpitaux de Toulouse, Toulouse, France., Passmore PA; Ageing group, Centre for Public Health, School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland, UK., Sims R; MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK., Williams J; MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK., Brayne C; Department of Public Health and Primary Care, Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK., Stewart R; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Sham P; Department of Psychiatry, State Key Laboratory of Brain and Cognitive Sciences, and Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong., Lovestone S; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK., Powell JF; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Publikováno v:
Neurobiology of aging [Neurobiol Aging] 2014 Dec; Vol. 35 (12), pp. 2883.e3-2883.e10. Date of Electronic Publication: 2014 Jul 24.
Autor:
Jones L; Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom., Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Peters O, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Rüther E, Carrasquillo MM, Pankratz VS, Younkin SG, Hardy J, O'Donovan MC, Owen MJ, Williams J
Publikováno v:
PloS one [PLoS One] 2010 Nov 15; Vol. 5 (11), pp. e13950. Date of Electronic Publication: 2010 Nov 15.
Autor:
Harold D; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK., Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J
Publikováno v:
Nature genetics [Nat Genet] 2009 Oct; Vol. 41 (10), pp. 1088-93. Date of Electronic Publication: 2009 Sep 06.
Autor:
Pardiñas, Antonio F, Holmans, Peter, Han, Jun, Nothen, Markus, Goate, Alison, Cruchaga, Carlos, Nowotny, Petra, Morris, John C, Mayo, Kevin, O'Donovan, Michael, Owen, Michael, Williams, Julie, Hubbard, Leon, Achilla, Evanthia, Agerbo, Esben, Barr, Cathy L, Böttger, Theresa Wimberly, Breen, Gerome, Cohen, Dan, Collier, David A, Curran, Sarah, Dempster, Emma, Dima, Danai, Lynham, Amy, Sabes-Figuera, Ramon, Flanagan, Robert J, Frangou, Sophia, Frank, Josef, Gasse, Christiane, Gaughran, Fiona, Giegling, Ina, Grove, Jakob, Hannon, Eilis, Hartmann, Annette M, Mantripragada, Kiran, Heißerer, Barbara, Helthuis, Marinka, Horsdal, Henriette Thisted, Ingimarsson, Oddur, Jollie, Karel, Kennedy, James L, Köhler, Ole, Konte, Bettina, Lang, Maren, Legge, Sophie E, Rees, Elliott, Lewis, Cathryn, MacCabe, James, Malhotra, Anil K, McCrone, Paul, Meier, Sandra M, Mill, Jonathan, Mors, Ole, Mortensen, Preben Bo, Nöthen, Markus M, O'Donovan, Michael C, MacCabe, James H, Owen, Michael J, Pedersen, Carsten B, Rietschel, Marcella, Rujescu, Dan, Schwalber, Ameli, Sigurdsson, Engilbert, Sørensen, Holger J, Spencer, Benjamin, Stefansson, Hreinn, McCarroll, Steven A, Støvring, Henrik, Strohmaier, Jana, Sullivan, Patrick, Vassos, Evangelos, Verbelen, Moira, Walters, James T R, Werge, Thomas, Baune, Bernhard T, Byrne, Enda M, Pocklington, Andrew J, Dannlowski, Udo, Eley, Thalia C, Hayward, Caroline, Martin, Nicholas G, McIntosh, Andrew M, Plomin, Robert, Porteous, David J, Wray, Naomi R, Caballero, Armando, Geschwind, Daniel H, Escott-Price, Valentina, Huckins, Laura M, Ruderfer, Douglas M, Santiago, Enrique, Sklar, Pamela, Stahl, Eli A, Won, Hyejung, Als, Thomas D, Andreassen, Ole A, Bækvad-Hansen, Marie, Ripke, Stephan, Pedersen, Carsten Bøcker, Børglum, Anders D, Bybjerg-Grauholm, Jonas, Djurovic, Srdjan, Durmishi, Naser, Pedersen, Marianne Giørtz, Golimbet, Vera, Hougaard, David M, Carrera, Noa, Mattheisen, Manuel, Molden, Espen, Nordentoft, Merete, Pejovic-Milovancevic, Milica, Silagadze, Teimuraz, Hansen, Christine Søholm, Stefansson, Kari, Steinberg, Stacy, Tosato, Sarah, Consortium, GERAD1, Consortium, CRESTAR, Kirov, George, Bishop, Sophie, Harold, Denise, Sims, Rebecca, Gerrish, Amy, Chapman, Jade, Abraham, Richard, Hollingworth, Paul, Pahwa, Jaspreet, Denning, Nicola, Cameron, Darren, Thomas, Charlene, Taylor, Sarah, Powell, John, Proitsi, Petroula, Lupton, Michelle, Lovestone, Simon, Passmore, Peter, Craig, David, McGuinness, Bernadette, Johnston, Janet, Hamshere, Marian L, Todd, Stephen, Maier, Wolfgang, Jessen, Frank, Heun, Reiner, Schurmann, Britta, Ramirez, Alfredo, Becker, Tim, Herold, Christine, Lacour, André, Drichel, Dmitriy
Publikováno v:
Pardiñas, A F, Holmans, P, Pocklington, A J, Escott-Price, V, Ripke, S, Carrera, N, Legge, S E, Bishop, S, Cameron, D, Hamshere, M L, Han, J, Hubbard, L, Lynham, A, Mantripragada, K, Rees, E, MacCabe, J H, McCarroll, S A, Baune, B T, Breen, G, Byrne, E M, Dannlowski, U, Eley, T C, Hayward, C, Martin, N G, McIntosh, A M, Plomin, R, Porteous, D J, Wray, N R, Caballero, A, Geschwind, D H, Huckins, L M, Ruderfer, D M, Santiago, E, Sklar, P, Stahl, E A, Won, H, Agerbo, E, Als, T D, Andreassen, O A, Bækvad-Hansen, M, Mortensen, P B, Pedersen, C B, Børglum, A D, Bybjerg-Grauholm, J, Djurovic, S, Durmishi, N, Pedersen, M G, Golimbet, V, Grove, J, Collier, D A 2018, ' Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection ', Nature Genetics, vol. 50, pp. 381–389 . https://doi.org/10.1038/s41588-018-0059-2
Nature genetics 50(3), 381-389 (2018). doi:10.1038/s41588-018-0059-2
Pardiñas, A F, Holmans, P A, Pocklington, A J, Escott-Price, V, Ripke, S, Carrera, N, Legge, S E, Bishop, S, Cameron, D, Hamshere, M L, Han, J, Hubbard, L, Lynham, A, Mantripragada, K, Rees, E, MacCabe, J H, McCarroll, S A, Baune, B T, Breen, G, Byrne, E M, Dannlowski, U, Eley, T C, Hayward, C, Martin, N G, McIntosh, A M, Plomin, R, Porteous, D J, Wray, N R, Caballero, A, Geschwind, D H, Huckins, L M, Ruderfer, D M, Santiago, E, Sklar, P, Stahl, E A, Won, H, Agerbo, E, Als, T D, Andreassen, O A, Bækvad-Hansen, M, Mortensen, P B, Pedersen, C B, Børglum, A D, Bybjerg-Grauholm, J, Djurovic, S, Durmishi, N, Pedersen, M G, Golimbet, V & Grove, J & Hougaard, D M 2018, ' Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection ', Nature Genetics . https://doi.org/10.1038/s41588-018-0059-2
GERAD1 Consortium: 2018, ' Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection ', Nature Genetics, vol. 50, no. 3, pp. 381-389 . https://doi.org/10.1038/s41588-018-0059-2
Nature genetics 50(3), 381-389 (2018). doi:10.1038/s41588-018-0059-2
Pardiñas, A F, Holmans, P A, Pocklington, A J, Escott-Price, V, Ripke, S, Carrera, N, Legge, S E, Bishop, S, Cameron, D, Hamshere, M L, Han, J, Hubbard, L, Lynham, A, Mantripragada, K, Rees, E, MacCabe, J H, McCarroll, S A, Baune, B T, Breen, G, Byrne, E M, Dannlowski, U, Eley, T C, Hayward, C, Martin, N G, McIntosh, A M, Plomin, R, Porteous, D J, Wray, N R, Caballero, A, Geschwind, D H, Huckins, L M, Ruderfer, D M, Santiago, E, Sklar, P, Stahl, E A, Won, H, Agerbo, E, Als, T D, Andreassen, O A, Bækvad-Hansen, M, Mortensen, P B, Pedersen, C B, Børglum, A D, Bybjerg-Grauholm, J, Djurovic, S, Durmishi, N, Pedersen, M G, Golimbet, V & Grove, J & Hougaard, D M 2018, ' Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection ', Nature Genetics . https://doi.org/10.1038/s41588-018-0059-2
GERAD1 Consortium: 2018, ' Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection ', Nature Genetics, vol. 50, no. 3, pp. 381-389 . https://doi.org/10.1038/s41588-018-0059-2
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life and decreased life expectancy. Lack of progress in improving treatment outcomes has been attributed to limited knowledge of the underlying biology, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14837d7d6a1cc02387718a4222dea866
https://kclpure.kcl.ac.uk/en/publications/771f5472-29c0-4a55-9c80-2687362a1edd
https://kclpure.kcl.ac.uk/en/publications/771f5472-29c0-4a55-9c80-2687362a1edd
Autor:
Hosp, Fabian, Vossfeldt, Hannes, Lannfelt, Lars, Holmans, Peter, O'Donovan, Michael, Owen, Michael J., Williams, Julie, Ingelsson, Martin, Lalowski, Maciej, Voigt, Aaron, Selbach, Matthias, Harold, Denise, Abraham, Richard, Hollingworth, Paul, Sims, Rebecca, Gerrish, Amy, Heinig, Matthias, Chapman, Jade, Russo, Giancarlo, Hamshere, Marian, Pahwa, Jaspreet Singh, Escott-Price, Valentina, Dowzell, Kimberley, Williams, Amy, Jones, Nicola, Thomas, Charlene, Stretton, Alexandra, Vasiljevic, Djordje, Morgan, Angharad, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Arumughan, Anup, Morgan, Kevin, Brown, Kristelle, Passmore, Peter, Craig, David, McGuinness, Bernadette, Todd, Stephen, Johnston, Janet, Holmes, Clive, Mann, David, Smith, A. David, Wyler, Emanuel, Love, Seth, Kehoe, Patrick G., Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Heun, Reiner, Genetic and Environmental Risk for Alzheimer's Disease GERAD1 Consortium, Schürmann, Britta, Ramirez, Alfredo, Becker, Tim, Herold, Christine, Lacour, André, Drichel, Dmitriy, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Landthaler, Markus, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison, Kauwe, John S. K., Cruchaga, Carlos, Nowotny, Petra, Morris, John C., Hubner, Norbert, Mayo, Kevin, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Al-Chalabi, Ammar, Shaw, Christopher E., Singleton, Andrew B., Wanker, Erich E., Guerreiro, Rita, Mühleisen, Thomas W., Nöthen, Markus M., Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Carrasquillo, Minerva M., Pankratz, V. Shane, Younkin, Steven G.
Publikováno v:
CELL REPORTS
Cell Rep 11(7), 1134-1146 (2015). doi:10.1016/j.celrep.2015.04.030
Cell Reports, Vol 11, Iss 7, Pp 1134-1146 (2015)
Cell Rep 11(7), 1134-1146 (2015). doi:10.1016/j.celrep.2015.04.030
Cell Reports, Vol 11, Iss 7, Pp 1134-1146 (2015)
SummarySeveral proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not completely understood. Here, we used quantitative interaction proteomics to identify binding partners of Amyloid beta precursor protei
Autor:
Escott-Price, Valentina, Sims, Rebecca, Passmore, Peter, ODonovan, Michael, Owen, Michael J, Holmes, Clive, Powell, John, Brayne, Carol, Gill, Michael, Mead, Simon, Goate, Alison, Cruchaga, Carlos, Lambert, Jean-Charles, van Duijn, Cornelia, Bannister, Christian, Maier, Wolfgang, Ramirez, Alfredo, Holmans, Peter, Jones, Lesley, Hardy, John, Seshadri, Sudha, Schellenberg, Gerard D, Amouyel, Philippe, Williams, Julie, Abraham, Richard, Harold, Denise, Hollingworth, Paul, Gerrish, Amy, Chapman, Jade, Russo, Giancarlo, Hamshere, Marian, Pahwa, Jaspreet Singh, Dowzell, Kimberley, Williams, Amy, Jones, Nicola, Thomas, Charlene, Vronskaya, Maria, Stretton, Alexandra, Morgan, Angharad, Taylor, Sarah, Lovestone, Simon, Proitsi, Petroula, Lupton, Michelle K, Rubinsztein, David C, Lawlor, Brian, Lynch, Aoibhinn, Brown, Kristelle, Majounie, Elisa, Craig, David, McGuinness, Bernadette, Todd, Stephen, Johnston, Janet, Mann, David, Smith, A David, Love, Seth, Kehoe, Patrick G, Fox, Nick, Rossor, Martin, Badarinarayan, Nandini, Collinge, John, Jessen, Frank, Heun, Reiner, Schürmann, Britta, Becker, Tim, Herold, Christine, Lacour, Andre, Drichel, Dmitriy, van den Bussche, Hendrik, Heuser, Isabella, GERAD/PERADES, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Kauwe, John S K, Nowotny, Petra, Morris, John C, consortia, IGAP, Mayo, Kevin, Livingston, Gill, Bass, Nicholas J, Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Al-Chalabi, Ammar, Shaw, Christopher E, Singleton, Andrew B, Morgan, Kevin, Guerreiro, Rita, Mühleisen, Thomas W, Nöthen, Markus M., Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Carrasquillo, Minerva M, Pankratz, V Shane, Younkin, Steven G
Publikováno v:
Brain, 138, 3673-3684. Oxford University Press
Brain 138(12), 3673-3684 (2015). doi:10.1093/brain/awv268
Brain 138(12), 3673-3684 (2015). doi:10.1093/brain/awv268
The identification of subjects at high risk for Alzheimer's disease is important for prognosis and early intervention. We investigated the polygenic architecture of Alzheimer's disease and the accuracy of Alzheimer's disease prediction models, includ
Autor:
Sassi, Celeste, Nalls, Michael A, Medway, Christopher, Clement, Naomi, Lord, Jenny, Turton, James, Bras, Jose, Almeida, Maria R, Consortium, ARUK, Holstege, Henne, Louwersheimer, Eva, van der Flier, Wiesje M, Ridge, Perry G, Scheltens, Philip, Van Swieten, John C, Santana, Isabel, Oliveira, Catarina, Morgan, Kevin, Powell, John F, Kauwe, John S, Cruchaga, Carlos, Goate, Alison M, Singleton, Andrew B, Gibbs, Jesse R, Guerreiro, Rita, Hardy, John, Passmore, Peter, Craig, David, Johnston, Janet, McGuinness, Bernadette, Todd, Stephen, Heun, Reinhard, Kölsch, Heike, Kehoe, Patrick G, Ding, Jinhui, Vardy, Emma R L C, Hooper, Nigel M, Mann, David M, Pickering-Brown, Stuart, Brown, Kristelle, Lowe, James, Smith, A David, Wilcock, Gordon, Warden, Donald, Lupton, Michelle K, Holmes, Clive, Troakes, Claire, Lunnon, Katie, Al-Sarraj, Safa, Brown, Kristelle S
Publikováno v:
Neurobiology of aging 46, 235.e1-235.e9 (2016). doi:10.1016/j.neurobiolaging.2016.04.004
Sassi, C, Nalls, M A, Ridge, P G, Gibbs, J R, Ding, J, Lupton, M K, Troakes, C, Lunnon, K, Al-Sarraj, S, Brown, K S, Medway, C, Clement, N, Lord, J, Turton, J, Bras, J, Almeida, M R, Holstege, H, Louwersheimer, E, van der Flier, W M, Scheltens, P, Van Swieten, J C, Santana, I, Oliveira, C, Morgan, K, Powell, J F, Kauwe, J S, Cruchaga, C, Goate, A M, Singleton, A B, Guerreiro, R & Hardy, J 2016, ' ABCA7 p.G215S as potential protective factor for Alzheimer's disease ', Neurobiology of Aging, vol. 46, pp. 235.e1–235.e9 . https://doi.org/10.1016/j.neurobiolaging.2016.04.004
Neurobiology of Aging, 46:235.e1. Elsevier Inc.
Neurobiology of Aging, 46. Elsevier Inc.
Neurobiology of Aging
Sassi, C, Nalls, M A, Ridge, P G, Gibbs, J R, Ding, J, Lupton, M K, Troakes, C, Lunnon, K, Al-Sarraj, S, Brown, K S, Medway, C, Clement, N, Lord, J, Turton, J, Bras, J, Almeida, M R, Holstege, H, Louwersheimer, E, van der Flier, W M, Scheltens, P, Van Swieten, J C, Santana, I, Oliveira, C, Morgan, K, Powell, J F, Kauwe, J S, Cruchaga, C, Goate, A M, Singleton, A B, Guerreiro, R & Hardy, J 2016, ' ABCA7 p.G215S as potential protective factor for Alzheimer's disease ', Neurobiology of Aging, vol. 46, pp. 235.e1–235.e9 . https://doi.org/10.1016/j.neurobiolaging.2016.04.004
Neurobiology of Aging, 46:235.e1. Elsevier Inc.
Neurobiology of Aging, 46. Elsevier Inc.
Neurobiology of Aging
Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8d8d19d810017eb1826c5a013735a96c
Autor:
Escott-Price, Valentina, Bellenguez, Céline, DeStefano, Anita L, Galimberti, Daniela, Scarpini, Elio, Bonuccelli, Ubaldo, Mancuso, Michelangelo, Siciliano, Gabriele, Moebus, Susanne, Mecocci, Patrizia, Zompo, Maria Del, Maier, Wolfgang, Hampel, Harald, Lambert, Jean-Charles, Pilotto, Alberto, Frank-García, Ana, Panza, Francesco, Solfrizzi, Vincenzo, Caffarra, Paolo, Nacmias, Benedetta, Perry, William, Mayhaus, Manuel, Lannfelt, Lars, Hakonarson, Hakon, Ibrahim-Verbaas, Carla A, Pichler, Sabrina, Carrasquillo, Minerva M, Ingelsson, Martin, Beekly, Duane, Alvarez, Victoria, Zou, Fanggeng, Valladares, Otto, Younkin, Steven G, Coto, Eliecer, Hamilton-Nelson, Kara L, Naj, Adam C, Gu, Wei, Razquin, Cristina, Pastor, Pau, Mateo, Ignacio, Owen, Michael J, Faber, Kelley M, Jonsson, Palmi V, Combarros, Onofre, O'Donovan, Michael C, Cantwell, Laura B, Sims, Rebecca, Soininen, Hilkka, Blacker, Deborah, Mead, Simon, Mosley, Thomas H, Bennett, David A, Harris, Tamara B, Fratiglioni, Laura, Holmes, Clive, de Bruijn, Renee F A G, Passmore, Peter, Jun, Gyungah, Montine, Thomas J, Bettens, Karolien, Rotter, Jerome I, Brice, Alexis, Morgan, Kevin, Foroud, Tatiana M, Kukull, Walter A, Hannequin, Didier, Powell, John F, Nalls, Michael A, Bis, Joshua C, Ritchie, Karen, Lunetta, Kathryn L, Kauwe, John S K, Boerwinkle, Eric, Riemenschneider, Matthias, Boada, Mercè, Hiltunen, Mikko, Martin, Eden R, Schmidt, Reinhold, Rujescu, Dan, Beecham, Gary W, Dartigues, Jean-François, Mayeux, Richard, Tzourio, Christophe, Hofman, Albert, Nöthen, Markus M, Graff, Caroline, Psaty, Bruce M, Haines, Jonathan L, Lathrop, Mark, Pericak-Vance, Margaret A, Grenier-Boley, Benjamin, Launer, Lenore J, Van Broeckhoven, Christine, Farrer, Lindsay A, van Duijn, Cornelia M, Ramirez, Alfredo, Seshadri, Sudha, Schellenberg, Gerard D, Amouyel, Philippe, Williams, Julie, Study, Cardiovascular Health, Russo, Giancarlo, Olson, Jean, Kronmal, Richard, Arnold, Alice M, Robbins, John, Carlson, Michelle, Burke, Gregory, Kuller, Lewis H, Tracy, Russell, Gottdiener, John, Prineas, Ronald, Wang, Li-San, Thornton-Wells, Tricia A, Becker, James T, Enright, Paul, Klein, Ronald, O'Leary, Daniel H, Denning, Nicola, Smith, Albert V, Chouraki, Vincent, Thomas, Charlene, Ikram, M Arfan, Zelenika, Diana, Vardarajan, Badri N, Kamatani, Yoichiro, Lin, Chiao-Feng, Choi, Seung-Hoan, Schmidt, Helena, Kunkle, Brian, Dunstan, Melanie L, Vronskaya, Maria, Consortium, United Kingdom Brain Expression, Johnson, Andrew D, Ruiz, Agustin, Bihoreau, Marie-Thérèse, Reitz, Christiane, Pasquier, Florence, Harold, Denise, Hollingworth, Paul, Hanon, Olivier, Fitzpatrick, Annette L, Buxbaum, Joseph D, Campion, Dominique, Crane, Paul K, Baldwin, Clinton, Becker, Tim, Gudnason, Vilmundur, Cruchaga, Carlos, Jones, Lesley, Craig, David, Amin, Najaf, Berr, Claudine, Lopez, Oscar L, De Jager, Philip L, Deramecourt, Vincent, Johnston, Janet A, Evans, Denis, Lovestone, Simon, Letenneur, Luc, Holmans, Peter, Hernández, Isabel, Rubinsztein, David C, Eiriksdottir, Gudny, Sleegers, Kristel, Goate, Alison M, Fiévet, Nathalie, Huentelman, Matthew J, Gill, Michael, Brown, Kristelle, Kamboh, M Ilyas, Gerrish, Amy, Keller, Lina, Barberger-Gateau, Pascale, McGuinness, Bernadette, Larson, Eric B, Myers, Amanda J, Dufouil, Carole, Todd, Stephen, Wallon, David, Love, Seth, Rogaeva, Ekaterina, Vedernikov, Alexey, Gallacher, John, George-Hyslop, Peter St, Clarimon, Jordi, Lleo, Alberto, Bayer, Anthony, Tsuang, Debby W, Yu, Lei, Tsolaki, Magda, Bossù, Paola, Spalletta, Gianfranco, Richards, Alexander, Proitsi, Petra, Collinge, John, Sorbi, Sandro, Garcia, Florentino Sanchez, Fox, Nick C, Hardy, John, Naranjo, Maria Candida Deniz, Bosco, Paolo, Clarke, Robert, Brayne, Carol
Publikováno v:
PLoS One (print), 9(6). Public Library of Science
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
PLoS One. 2014 Jun 12;9(6):e94661
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
PLoS ONE, Vol 9, Iss 6, p e94661 (2014)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE
PLoS One
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
PLOS ONE 9(6), e94661 (2014). doi:10.1371/journal.pone.0094661
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
PLoS One. 2014 Jun 12;9(6):e94661
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
PLoS ONE, Vol 9, Iss 6, p e94661 (2014)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE
PLoS One
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
PLOS ONE 9(6), e94661 (2014). doi:10.1371/journal.pone.0094661
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d68243634f4f4d3d07b6e1bd04d102
http://hdl.handle.net/11391/1314148
http://hdl.handle.net/11391/1314148
Autor:
Proitsi, Petroula, Lupton, Michelle K, Velayudhan, Latha, Newhouse, Stephen, Fogh, Isabella, Tsolaki, Magda, Daniilidou, Makrina, Pritchard, Megan, Kloszewska, Iwona, Soininen, Hilkka, Mecocci, Patrizia, Vellas, Bruno, Williams, Julie, Harold, Denise, Sims, Rebecca, Gerrish, Amy, Chapman, Jade, Escott-Price, Valentina, Abraham, Richard, Hollingworth, Paul, Hamshere, Marian, Singh Pahwa, Jaspreet, Dowzell, Kimberley, Williams, Amy, Jones, Nicola, Thomas, Charlene, Stretton, Alexandra, Morgan, Angharad R, Williams, Kate, Lovestone, Simon, Powell, John F, Brayne, Carol, Rubinsztein, David C, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S, Passmore, Peter, Craig, David, Mcguinness, Bernadette, Johnston, Janet A., Todd, Stephen, Holmes, Clive, Mann, David, Smith, A David, Love, Seth, Kehoe, Patrick G, Hardy, John, Guerreiro, Rita, Singleton, Andrew B, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Heun, Reiner, Schürmann, Britta, Ramirez, Alfredo, Becker, Tim, Herold, Christine, Lacour, André, Drichel, Dmitriy, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison M, Kauwe, John S K, Cruchaga, Carlos, Nowotny, Petra, Morris, John C, Mayo, Kevin, Livingston, Gill, Bass, Nicholas J, Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Nöthen, Markus M, Holmans, Peter A, O'Donovan, Michael C, Owen, Michael J, Stewart, Robert C, Sham, Pak
Publikováno v:
PLoS medicine 11(9), e1001713 (2014). doi:10.1371/journal.pmed.1001713
PLoS Medicine
PLoS Medicine, Vol 11, Iss 9, p e1001713 (2014)
Proitsi, P, Lupton, M K, Velayudhan, L, Newhouse, S, Fogh, I, Tsolaki, M, Daniilidou, M, Pritchard, M, Kloszewska, I, Soininen, H, Mecocci, P, Vellas, B, Williams, J, Harold, D, Sims, R, Gerrish, A, Chapman, J, Escott-Price, V, Abraham, R, Hollingworth, P, Hamshere, M, Singh Pahwa, J, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Williams, K, Lovestone, S, Powell, J F, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P, Craig, D, Mcguinness, B, Johnston, J A, Todd, S, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Guerreiro, R, Singleton, A B, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Heun, R, Schürmann, B, Ramirez, A, Becker, T, Herold, C, Lacour, A, Drichel, D, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Nöthen, M M, Holmans, P A, O'Donovan, M C, Owen, M J, Williams, J, Stewart, R C & Sham, P 2014, ' Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease : A Mendelian Randomization Analysis ', PLoS Medicine, vol. 11, no. 9 . https://doi.org/10.1371/journal.pmed.1001713
Proitsi, P, Lupton, M K, Velayudhan, L, Newhouse, S, Fogh, I, Tsolaki, M, Daniilidou, M, Pritchard, M, Kloszewska, I, Soininen, H, Mecocci, P, Vellas, B, Williams, J, Stewart, R, Sham, P, Lovestone, S, Powell, J F 2014, ' Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease : a Mendelian randomization analysis ', PL o S Medicine, vol. 11, no. 9, pp. e1001713 . https://doi.org/10.1371/journal.pmed.1001713
PLoS Medicine
PLoS Medicine, Vol 11, Iss 9, p e1001713 (2014)
Proitsi, P, Lupton, M K, Velayudhan, L, Newhouse, S, Fogh, I, Tsolaki, M, Daniilidou, M, Pritchard, M, Kloszewska, I, Soininen, H, Mecocci, P, Vellas, B, Williams, J, Harold, D, Sims, R, Gerrish, A, Chapman, J, Escott-Price, V, Abraham, R, Hollingworth, P, Hamshere, M, Singh Pahwa, J, Dowzell, K, Williams, A, Jones, N, Thomas, C, Stretton, A, Morgan, A R, Williams, K, Lovestone, S, Powell, J F, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K S, Passmore, P, Craig, D, Mcguinness, B, Johnston, J A, Todd, S, Holmes, C, Mann, D, Smith, A D, Love, S, Kehoe, P G, Hardy, J, Guerreiro, R, Singleton, A B, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Heun, R, Schürmann, B, Ramirez, A, Becker, T, Herold, C, Lacour, A, Drichel, D, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Nöthen, M M, Holmans, P A, O'Donovan, M C, Owen, M J, Williams, J, Stewart, R C & Sham, P 2014, ' Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease : A Mendelian Randomization Analysis ', PLoS Medicine, vol. 11, no. 9 . https://doi.org/10.1371/journal.pmed.1001713
Proitsi, P, Lupton, M K, Velayudhan, L, Newhouse, S, Fogh, I, Tsolaki, M, Daniilidou, M, Pritchard, M, Kloszewska, I, Soininen, H, Mecocci, P, Vellas, B, Williams, J, Stewart, R, Sham, P, Lovestone, S, Powell, J F 2014, ' Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease : a Mendelian randomization analysis ', PL o S Medicine, vol. 11, no. 9, pp. e1001713 . https://doi.org/10.1371/journal.pmed.1001713
In this study, Proitsi and colleagues use a Mendelian randomization approach to dissect the causal nature of the association between circulating lipid levels and late onset Alzheimer's Disease (LOAD) and find that genetic predisposition to increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83efcf41fc9a916ef8b911ebe92c0f8b