Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Joseph E. Powell"'
Autor:
Jennifer Lim, Venessa Chin, Kirsten Fairfax, Catia Moutinho, Dan Suan, Hanlee Ji, Joseph E. Powell
Publikováno v:
Nature Reviews Genetics.
Publikováno v:
Nature Reviews Genetics.
Autor:
Matthew A. Brown, Nicholas G. Martin, Joseph E. Powell, Jeremy Cohen, Dorrilyn Rajbhandari, Andrew Rhodes, Scott D. Gordon, Jason Meyer, Qiang Li, Elizabeth Peach, Shannon D’Urso, Gabriel Cuellar-Partida, Colin McArthur, Symen Ligthart, Simon Finfer, Balasubramanian Venkatesh, David M. Evans, John Myburgh, Erika De Guzman, Sarah E. Medland, Antje Blumenthal
Publikováno v:
Twin Research and Human Genetics, 23(4), 204-213. Cambridge University Press
Previous genetic association studies have failed to identify loci robustly associated with sepsis, and there have been no published genetic association studies or polygenic risk score analyses of patients with septic shock, despite evidence suggestin
Autor:
Ramon Massoni-Badosa, Joseph E. Powell, Maria Salvany, Catia Moutinho, Carlota Rubio-Perez, Vanessa T. Chin, Joan Seoane, Eduard Batlle, Dominik C. Kaczorowski, Ester Planas-Rigol, Marc Elosua-Bayes, Chia-Ling Chan, Paula Nieto, Domenica Marchese, Josep M. Piulats, Ana Henriques, Ivo Gut, Richard Gallagher, Holger Heyn, Juan L. Trincado, Patricia Lorden, Juan C. Nieto, Elisabetta Mereu, Sara Ruiz, Angela Chou, Sergio Aguilar-Fernández
Publikováno v:
Genome Research
Dipòsit Digital de la UB
Universidad de Barcelona
Genome Res
Dipòsit Digital de la UB
Universidad de Barcelona
Genome Res
The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients, and biomarkers for prognosis and treatment response lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c8407d0e6650bb7bd44e14fc1d9cc0
http://hdl.handle.net/2445/180737
http://hdl.handle.net/2445/180737
Autor:
Sanjay Warrier, Sandra A O'Toole, Nenad Bartonicek, Anthony M. Joshua, Sunny Z. Wu, Simon Junankar, Richard A. Scolyer, Kate Harvey, James S. Wilmott, Davendra Segara, Lisa G. Horvath, Bertrand Z. Yeung, Alexander Swarbrick, Mun N. Hui, Georgina V. Long, Aurélie Cazet, Camelia Quek, Julia Beretov, Chia-Ling Carynn Chan, Ghamdan Al-Eryani, Elgene Lim, Joseph E. Powell, Phillip D. Stricker, Daniel L. Roden, Ewan A. Millar, Cindy Mak
Publikováno v:
Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Background High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult, preclud
Autor:
Oswald Matika, Tatjana Sitt, Musa A. Hassan, Johanneke D. Hemmink, Elizabeth J. Poole, B.M. deC. Bronsvoort, Eaj Cook, Andrea Talenti, David Wragg, P. Latre de Late, Antoinette Aluoch Miyunga, W. I. Morrison, Phil Toye, James Prendergast, Timothy Connelley, Joseph E. Powell, Stephen Mwaura, M. Chepkowny, Rebecca Callaby, Gideon Ndambuki, Edith Paxton, Karen Marshall, Liam J. Morrison, R. Njeru, Harriet Auty
Publikováno v:
Wragg, D, Cook, E A J, Latré de Laté, P, Sitt, T, Hemmink, H, Chepkowny, M, Njeru, M K, Poole, E J, Powell, J, Paxton, E, Callaby, R, Talenti, A, Miyunga, A A, Ndambuki, G, Mwaura, S, Auty, H, Matika, O, Hassan, M, Marshall, K, Connelley, T, Morrison, L, Bronsvoort, M, Morrison, I, Toye, P G & Prendergast, J 2022, ' A locus conferring tolerance to Theileria infection in African cattle ', PLoS Genetics, vol. 18, no. 4, e1010099 . https://doi.org/10.1371/journal.pgen.1010099
East Coast fever, a tick-borne cattle disease caused by theTheileria parvaparasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Boran
Autor:
Nathan J. Palpant, Maika Matsumoto, Tianqi Ma, Michael Thompson, Anne Senabouth, Quan Nguyen, Joseph E. Powell
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics, Vol 12 (2021)
Finding cell states and their transcriptional relatedness is a main outcome from analysing single-cell data. In developmental biology, determining whether cells are related in a differentiation lineage remains a major challenge. A seamless analysis p
Autor:
Alice Pébay, Jue-Sheng Ong, Alberta A H J Thiadens, UK Biobank Eye, Jamie E. Craig, Denize Atan, Anne Senabouth, Michiaki Kubo, Caroline C W Klaver, Hélène Choquet, Puya Gharahkhani, Hannah Currant, Mark James Simcoe, Janey L Wiggs, Paul J. Foster, Charles A Reisman, David A. Mackey, Stuart MacGregor, Cornelia M. van Duijn, Maciej S. Daniszewski, Pirro G. Hysi, Anthony P Khawaja, Alex W. Hewitt, Louis R. Pasquale, Seyhan Yazar, Pieter W.M. Bonnemaijer, Peng T. Khaw, Jason Charng, Tin Aung, Joseph E. Powell, Tomas W Fitzgerald, Ewan Birney, Christopher J Hammond, Eric Jorgenson, Praveen J. Patel
Publikováno v:
PLoS Genetics, Vol 17, Iss 10 (2021)
PLoS Genetics
Plos Genetics, 17
Plos Genetics, 17, 5
PLoS Genetics, Vol 17, Iss 5, p e1009497 (2021)
PLoS Genetics, Vol 17, Iss 10, p e1009858 (2021)
PLoS Genetics, 17(5):e1009497. Public Library of Science
2021, ' Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images ', PLoS Genetics, vol. 17, no. 5, e1009497, pp. e1009497 . https://doi.org/10.1371/journal.pgen.1009497
PLoS Genetics
Plos Genetics, 17
Plos Genetics, 17, 5
PLoS Genetics, Vol 17, Iss 5, p e1009497 (2021)
PLoS Genetics, Vol 17, Iss 10, p e1009858 (2021)
PLoS Genetics, 17(5):e1009497. Public Library of Science
2021, ' Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images ', PLoS Genetics, vol. 17, no. 5, e1009497, pp. e1009497 . https://doi.org/10.1371/journal.pgen.1009497
Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseases including glaucoma. We present the first large-scale genome-wide association study of inner retinal morphology using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d04ec387b1f0d29dd0fb05b312e9634
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/235428
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/235428
Autor:
Alexander Holloway, Joseph E. Powell, Naomi R. Wray, Peter Smartt, Luke R. Lloyd-Jones, Jacob Gratten, Chloe X. Yap
Publikováno v:
European Journal of Human Genetics. 26:1361-1368
Trans-eQTLs have been implicated in complex traits and common diseases, but many were initially identified on the basis of having an effect in cis, and there has been no assessment of the significance of the overlap in relation to chance expectations
Autor:
Quan Nguyen, Anne Senabouth, Han Sheng Chiu, Nathan J. Palpant, Timothy J. C. Bruxner, Joseph E. Powell, Angelika N. Christ, Samuel W. Lukowski
Publikováno v:
Genome Research. 28:1053-1066
Heterogeneity of cell states represented in pluripotent cultures have not been described at the transcriptional level. Since gene expression is highly heterogeneous between cells, single-cell RNA sequencing can be used to identify how individual plur