Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Thomas Lehner"'
Autor:
Jonathan Warrell, Stamatios N. Sotiropoulos, Michael J. Gandal, Geetha Senthil, Justin T. Baker, Stefan Bekiranov, Jacob M. Taylor, Alán Aspuru-Guzik, Thomas Lehner, Matteo Bastiani, Aram W. Harrow, John D. Murray, Michael J. McConnell, Alan Anticevic, Prashant Emani, Guillermo Sapiro, Mark Gerstein
Publikováno v:
Nat Methods
The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems. Innovatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e6b894abf5f9be5f976cfcf66f8701
http://arxiv.org/abs/1911.07127
http://arxiv.org/abs/1911.07127
Autor:
Amanda Dobbyn, Laura M. Huckins, James Boocock, Laura G. Sloofman, Benjamin S. Glicksberg, Claudia Giambartolomei, Gabriel E. Hoffman, Thanneer M. Perumal, Kiran Girdhar, Yan Jiang, Towfique Raj, Douglas M. Ruderfer, Robin S. Kramer, Dalila Pinto, Schahram Akbarian, Panos Roussos, Enrico Domenici, Bernie Devlin, Pamela Sklar, Eli A. Stahl, Solveig K. Sieberts, Joseph Buxbaum, David Lewis, Raquel Gur, Chang-Gyu Hahn, Keisuke Hirai, Hiroyoshi Toyoshiba, Laurent Essioux, Lara Mangravite, Mette Peters, Thomas Lehner, Barbara Lipska, A. Ercument Cicek, Cong Lu, Kathryn Roeder, Lu Xie, Konrad Talbot, Scott E. Hemby, Andrew Browne, Andrew Chess, Aaron Topol, Alexander Charney, Ben Readhead, Bin Zhang, David A. Bennett, David H. Kavanagh, Eric E. Schadt, Hardik R. Shah, Jun Zhu, Jessica S. Johnson, John F. Fullard, Joel T. Dudley, Kristen J. Brennand, Menachem Fromer, Milind C. Mahajan, Shaun M. Purcell, Tymor Hamamsy, Vahram Haroutunian, Ying-Chih Wang, Zeynep H. Gümüş, Geetha Senthil, Robin Kramer, Benjamin A. Logsdon, Jonathan M.J. Derry, Kristen K. Dang, Roberto Visintainer, Leslie A. Shinobu, Patrick F. Sullivan, Lambertus L. Klei
Publikováno v:
American Journal of Human Genetics
Causal genes and variants within genome-wide association study (GWAS) loci can be identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and determining which variants underlie both GWAS and eQTL signals. Most analys
Autor:
Meera E. Modi, Stephen Sanders, Guoping Feng, Paul Avillach, Carrie E. Bearden, Anne Pariser, Thomas Lehner, Andres Moreno-De-Luca, Audrey Thurm, David H. Ledbetter, Raquel E. Gur, Elise Douard, Jonathan Sebat, Joseph Hostyk, Ricardo E. Dolmetsch, David B. Goldstein, Daniel H. Geschwind, Christa Lese Martin, David C. Glahn, Sébastien Jacquemont, Armin Raznahan, Mustafa Sahin, Rodney C. Samaco, Alan Anticevic, Jennifer G. Mulle, Sergiu P. Paşca
Publikováno v:
Nat Med
other univ website
Nature medicine, vol 25, iss 10
other univ website
Nature medicine, vol 25, iss 10
De novo and inherited rare genetic disorders (RGDs) are a major cause of human morbidity, frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies and data sharing have revolutionized the identification and diagnosis of
Autor:
Christine Stevens, Michael E. Zwick, Deepthi Rajagopalan, Mara Parellada, David J. Cutler, Li-San Wang, Norio Ozaki, Jinlu Cai, Lauren A. Weiss, Patricia Jiménez González, Jeffrey C. Barrett, Silvia De Rubeis, Helena Kilpinen, Alexander Kolevzon, Timothy W. Yu, Michael John Owen, Geraldine Dawson, Martin Schulte-Rüther, Jeremy R. Parr, Aarno Palotie, Eftichia Duketis, Lambertus Klei, Irene Lee, Bridget A. Fernandez, Aniko Sabo, Matthew W. State, Sarah Curran, Lucy Crooks, Chad M. Schafer, Avi Ma'ayan, Stephen Sanders, Evan T. Geller, Monica Biscaldi, Stephen W. Scherer, Christopher S. Poultney, Mark J. Daly, Patrick Bolton, Kaija Puura, Maria H. Chahrour, Michael Gill, Li Liu, Louise Gallagher, Ryan K. C. Yuen, Jack A. Kosmicki, Abraham Reichenberg, Christine M. Freitag, Shaun Purcell, Andreas G. Chiocchetti, Peter Szatmari, Sabine M. Klauck, Shih-Chen Fu, Christian R. Marshall, Joseph D. Buxbaum, Tarjinder Singh, Bernie Devlin, Chiao-Feng Lin, A. Ercument Cicek, Karola Rehnström, Pamela Sklar, Otto Valladares, Michael Sachse, Terho Lehtimäki, R. Sean Hill, Arthur P. Goldberg, A. Jeremy Willsey, Jing Lei, Branko Aleksic, Menachem Fromer, Yan Kou, Jessica M. Brownfeld, Annette Voran, Kathryn Roeder, Gerard D. Schellenberg, David Skuse, Thomas Lehner, Hilary Coon, Benjamin M. Neale, Iuliana Ionita-Laza, Kristiina Tammimies, Stephen J. Guter, Christopher A. Walsh, James S. Sutcliffe, Xin-Xin He, Alison L. McInnes, Emily L. Crawford, Nicholas G. Campbell, Angel Carracedo, R. Susan Walker, Edwin H. Cook, Kaitlin E. Samocha, Christina M. Hultman
Publikováno v:
Nature
The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937
Autor:
Carrie E. Bearden, Donna M. McDonald-McGinn, Raquel E. Gur, Joris Vermeesch, Ann Swillen, Eva W.C. Chow, Jas Vorstman, M. van den Bree, Anne S. Bassett, Thomas Lehner, Bernice E. Morrow, Beverly S. Emanuel, Stephen T. Warren, Michael John Owen
Publikováno v:
Molecular psychiatry, vol 22, iss 12
Rare copy number variants contribute significantly to the risk for schizophrenia, with the 22q11.2 locus consistently implicated. Individuals with the 22q11.2 deletion syndrome (22q11DS) have an estimated 25-fold increased risk for schizophrenia spec
Autor:
Marija Kundakovic, Jonathan Mill, Allison E. Ashley-Koch, Soraya Scuderi, Lijing Yao, Gregory E. Crawford, Shyam Prabhakar, Matthew W. State, Jeremie Poschmann, Nenad Sestan, Dalila Pinto, Nancy Francoeur, Emily Wu, Neelroop N. Parikshak, Angus C. Nairn, Gerhard A. Coetzee, Thomas Lehner, Wenjie Sun, Amanda J. Price, Daifeng Wang, Mario Skarica, Lara M. Mangravite, Anahita Amiri, Gianfilippo Coppola, Andrew E. Jaffe, Alexej Abyzov, Vivek Swarup, Amber Thomas, Chris Armoskus, Shannon Schreiner, Hyejung Won, Andrea Beckel-Mitchener, Yan Jiang, James A. Knowles, Daniel H. Geschwind, Timothy E. Reddy, Pamela Sklar, Annie W. Shieh, Gregory A. Wray, Eirene Markenscoff-Papadimitriou, Chunyu Liu, Eugenio Mattei, Zhiping Weng, Michael J. Purcaro, Alexey Kozlenkov, Sirisha Pochareddy, Donna M. Werling, Shuang Liu, Nicole North, Junko Tsuji, Sherman M. Weissman, Kay Grennan, Mette A. Peters, Harm van Bakel, Heather Witt, Geetha Senthil, David M. Panchision, Yongjun Wang, Robert Sebra, Schahram Akbarian, Flora M. Vaccarino, Mark Gerstein, Menachem Fromer, Mikihito Shibata, Nikolay A. Ivanov, Chloe C. Y. Wong, Patrick F. Sullivan, Larsson Omberg, Kevin P. White, Fabio C. P. Navarro, Robert R. Kitchen, Jennifer Herstein, Benjamin P. Berman, David H. Kavanagh, Kai Wang, Mingfeng Li, Xuming Xu, Zhen Li, A. Jeremy Willsey, Stella Dracheva, Taejeong Bae, Robert Gao, Panos Roussos, Peggy J. Farnham
Publikováno v:
Nature neuroscience, vol 18, iss 12
Recent research on disparate psychiatric disorders has implicated rare variants in genes involved in global gene regulation and chromatin modification, as well as many common variants located primarily in regulatory regions of the genome. Understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c552ee75c481c3387e933d978d7f694e
https://europepmc.org/articles/PMC4675669/
https://europepmc.org/articles/PMC4675669/
Autor:
Stephan Ripke, Weihua Guan, Alan R. Sanders, Laura Nisenbaum, Barbara Franke, Patrick F. Sullivan, P. McGuffin, Pamela Sklar, Cathryn M. Lewis, Aravinda Chakravarti, Neale Bm, Nicholas G. Martin, Ann E. Pulver, Richard Anney, Guy A. Rouleau, Marcella Rietschel, Jordan W. Smoller, Claudine Laurent, Brien P. Riley, Thomas F. Wienker, Roy H. Perlis, Witte J.G. Hoogendijk, Ruchi Upmanyu, Jaana Suvisaari, Christina M. Hultman, Patrick J. McGrath, Susan L. Santangelo, Michael Conlon O'Donovan, Jennifer Stone, Dieter Wildenaver, Nicholas John Craddock, Edwin J. C. G. van den Oord, William Coryell, Gerard D. Schellenberg, Pablo V. Gejman, Arnoldo Frigessi, Anita Thapar, Michael Steffens, Bryan J. Mowry, Mark J. Daly, Susan L. Slager, Eve H. Pickering, Michael Gill, Audra Moran, Eco J. C. de Geus, Shaun Purcell, John P. Rice, Douglas F. Levinson, Patrick Sullivan, S. P. Hamilton, Peter Szatmari, William Lawson, Anil K. Malhotra, James B. Potash, William A. Scheftner, Federica Tozzi, Aiden Corvin, J. J. McGough, John I. Nurnberger, Alexandre A. Todorov, Joseph D. Buxbaum, Jonathan Sebat, Susan L. Smalley, Jung-Ying Tzeng, Lindsey Kent, Walter J. Muir, Michael Boehnke, Phillip Awadalla, Thomas Lehner, Valentina Moskvina, Peter Holmans, Hugh Gurling, Veronica J. Vieland, Stephen W. Scherer, Susanne Lucae, Ayman H. Fanous, Danyu Lin, Naomi R. Wray, Sibylle G. Schwab, Joseph Piven, Dorret I. Boomsma, Tiffany A. Greenwood, Sven Cichon, James S. Sutcliffe, Manuel A. R. Ferreira, Frank Dudbridge, A.H.M. Willemsen, Todd Lencz, Stafam Kloiber, Danielle Posthuma, James Offord, Matthew Flickinger, Michael John Owen, David St Clair, Roel A. Ophoff, Bernie Devlin, Douglas M. Ruderfer, Leena Peltonen, Brenda W.J.H. Penninx, Richard D. Todd, Kenneth S. Kendler, Sari Kivikko, Dan E. Arking, Elizabeth G. Holliday, Markus M. Noethen, René Breuer, John R. Kelsoe, Thomas G. Schulze, Josephine Elia, Edwin H. Cook, Nicholas J. Schork, Douglas Blackwood, Margit Burmeister, Myrna M. Weissman, Hakon Hakonarson, Laura J. Scott, Eric Mick, Pierandrea Muglia, Ole A. Andreassen, Jun Li, Stephen V. Faraone, Jan K. Buitelaar
Publikováno v:
American Journal of Psychiatry, 166, 540-56
American Journal of Psychiatry, 166, 5, pp. 540-56
American Journal of Psychiatry, 166(5), 540-556. American Psychiatric Association
Cichon, S, Craddock, N, Daly, M J, Faraone, S V, Gejman, P V, Kelsoe, J, Lehner, T, Levinson, D F, Moran, A P, Sklar, P, Sullivan, P F, Boomsma, D I, de Geus, E J C, Posthuma, D & Willemsen, G 2009, ' Genomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders ', American Journal of Psychiatry, vol. 166, no. 5, pp. 540-556 . https://doi.org/10.1176/appi.ajp.2008.08091354
American Journal of Psychiatry, 166, 5, pp. 540-56
American Journal of Psychiatry, 166(5), 540-556. American Psychiatric Association
Cichon, S, Craddock, N, Daly, M J, Faraone, S V, Gejman, P V, Kelsoe, J, Lehner, T, Levinson, D F, Moran, A P, Sklar, P, Sullivan, P F, Boomsma, D I, de Geus, E J C, Posthuma, D & Willemsen, G 2009, ' Genomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders ', American Journal of Psychiatry, vol. 166, no. 5, pp. 540-556 . https://doi.org/10.1176/appi.ajp.2008.08091354
Contains fulltext : 80575.pdf (Publisher’s version ) (Closed access) OBJECTIVE: The authors conducted a review of the history and empirical basis of genomewide association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to
Autor:
Charles, Rotimi, Akin, Abayomi, Alash'le, Abimiku, Victoria May, Adabayeri, Clement, Adebamowo, Ezekiel, Adebiyi, Adebowale D, Ademola, Adebowale, Adeyemo, Dwomoa, Adu, Dissou, Affolabi, Godfred, Agongo, Samuel, Ajayi, Sally, Akarolo-Anthony, Rufus, Akinyemi, Albert, Akpalu, Marianne, Alberts, Orlando, Alonso Betancourt, Ahmed Mansour, Alzohairy, Gobena, Ameni, Olukemi, Amodu, Gabriel, Anabwani, Kristian, Andersen, Fatiu, Arogundade, Oyedunni, Arulogun, Danny, Asogun, Rasheed, Bakare, Naby, Balde, Mary Lynn, Baniecki, Christine, Beiswanger, Alia, Benkahla, Lara, Bethke, Micheal, Boehnke, Vincent, Boima, James, Brandful, Andrew I, Brooks, Frank C, Brosius, Chester, Brown, Bruno, Bucheton, David T, Burke, Barrington G, Burnett, Stacy, Carrington-Lawrence, Nadia, Carstens, John, Chisi, Alan, Christoffels, Richard, Cooper, Heather, Cordell, Nigel, Crowther, Talishiea, Croxton, Jantina, de Vries, Leslie, Derr, Peter, Donkor, Seydou, Doumbia, Audrey, Duncanson, Ivy, Ekem, Ahmed, El Sayed, Mark E, Engel, John C K, Enyaru, Dean, Everett, Faisal M, Fadlelmola, Eyitayo, Fakunle, Kenneth H, Fischbeck, Anne, Fischer, Onikepe, Folarin, Junaid, Gamieldien, Robert F, Garry, Simani, Gaseitsiwe, Rasheed, Gbadegesin, Anita, Ghansah, Maria, Giovanni, Parham, Goesbeck, F Xavier, Gomez-Olive, Donald S, Grant, Ravnit, Grewal, Mark, Guyer, Neil A, Hanchard, Christian T, Happi, Scott, Hazelhurst, Branwen J, Hennig, Christiane, Hertz, Fowler, Winston, Hide, Friedhelm, Hilderbrandt, Christopher, Hugo-Hamman, Muntaser E, Ibrahim, Regina, James, Yasmina, Jaufeerally-Fakim, Carolyn, Jenkins, Ute, Jentsch, Pan-Pan, Jiang, Moses, Joloba, Victor, Jongeneel, Fourie, Joubert, Mukthar, Kader, Kathleen, Kahn, Pontiano, Kaleebu, Saidi H, Kapiga, Samar Kamal, Kassim, Ishmael, Kasvosve, Jonathan, Kayondo, Bernard, Keavney, Adeodata, Kekitiinwa, Sheik Humarr, Khan, Paul, Kimmel, Mary-Claire, King, Robert, Kleta, Mathurin, Koffi, Jeffrey, Kopp, Matthias, Kretzler, Judit, Kumuthini, Samuel, Kyobe, Catherine, Kyobutungi, Daniel T, Lackland, Karen A, Lacourciere, Guida, Landouré, Rita, Lawlor, Thomas, Lehner, Maia, Lesosky, Naomi, Levitt, Katherine, Littler, Zane, Lombard, Jeanne F, Loring, Sylvester, Lyantagaye, Annette, Macleod, Ebony B, Madden, Chengetai R, Mahomva, Julie, Makani, Manmak, Mamven, Marape, Marape, Graeme, Mardon, Patricia, Marshall, Darren P, Martin, Daniel, Masiga, Robin, Mason, Michael, Mate-Kole, Enock, Matovu, Mary, Mayige, Bongani M, Mayosi, Jean Claude, Mbanya, Sheryl A, McCurdy, Mark I, McCarthy, Helen, McIlleron, S O, Mc'Ligeyo, Corrine, Merle, Ana Olga, Mocumbi, Charles, Mondo, John V, Moran, Ayesha, Motala, Marva, Moxey-Mims, Wata Sununguko, Mpoloka, Chisomo L, Msefula, Thuli, Mthiyane, Nicola, Mulder, Gebregziab her, Mulugeta, Dieuodonne, Mumba, John, Musuku, Mo, Nagdee, Oyekanmi, Nash, Daouda, Ndiaye, Anh Quynh, Nguyen, Mark, Nicol, Oathokwa, Nkomazana, Shane, Norris, Betty, Nsangi, Alexander, Nyarko, Moffat, Nyirenda, Eileen, Obe, Reginald, Obiakor, Abraham, Oduro, Solomon F, Ofori-Acquah, Okechukwu, Ogah, Stephen, Ogendo, Kwaku, Ohene-Frempong, Akinlolu, Ojo, Timothy, Olanrewaju, John, Oli, Charlotte, Osafo, Odile, Ouwe Missi Oukem-Boyer, Bruce, Ovbiagele, Andrew, Owen, Mayowa Ojo, Owolabi, Lukman, Owolabi, Ellis, Owusu-Dabo, Guillaume, Pare, Rulan, Parekh, Hugh G, Patterton, Margaret B, Penno, Jane, Peterson, Rembert, Pieper, Jacob, Plange-Rhule, Martin, Pollak, Julia, Puzak, Rajkumar S, Ramesar, Michele, Ramsay, Rebekah, Rasooly, Shiksha, Reddy, Pardis C, Sabeti, Kwamena, Sagoe, Tunde, Salako, Oumar, Samassékou, Manjinder S, Sandhu, Osman, Sankoh, Fred Stephen, Sarfo, Marie, Sarr, Gasnat, Shaboodien, Issa, Sidibe, Gustave, Simo, Martin, Simuunza, Liam, Smeeth, Eugene, Sobngwi, Himla, Soodyall, Hermann, Sorgho, Oumou, Sow Bah, Sudha, Srinivasan, Dan J, Stein, Ezra S, Susser, Carmen, Swanepoel, Godfred, Tangwa, Andrew, Tareila, Ozlem, Tastan Bishop, Bamidele, Tayo, Nicki, Tiffin, Halidou, Tinto, Ekaete, Tobin, Stephen Meir, Tollman, Mahamadou, Traoré, Marsha J, Treadwell, Jennifer, Troyer, Masego, Tsimako-Johnstone, Vincent, Tukei, Ifeoma, Ulasi, Nzovu, Ulenga, Beverley, van Rooyen, Ablo Prudence, Wachinou, Salina P, Waddy, Alisha, Wade, Misaki, Wayengera, James, Whitworth, Louise, Wideroff, Cheryl A, Winkler, Sarah, Winnicki, Ambroise, Wonkam, Mengistu, Yewondwos, Tadase, sen, Nathan, Yozwiak, Heather, Zar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::60e5b038d43dbb4ce5dafc3d1f93ac20
http://hdl.handle.net/11562/937920
http://hdl.handle.net/11562/937920
Autor:
Thomas Lehner, Veronica J. Vieland, Marco A. Azaro, Linda M. Brzustowicz, Kimberly A. Walters
Publikováno v:
Human heredity. 78(1)
Objectives: Linkage analysis can help determine regions of interest in whole-genome sequence studies. However, many linkage studies rely on older microsatellite (MSAT) panels. We set out to determine whether results would change if we regenotyped fam
Autor:
Linda D. Youngman, Steven B. Auerbach, Maude L. Blundell, Dvora Shmulewitz, Jeffrey M. Friedman, Simon Heath, Jeffrey D. Winick, Markus Stoffel, Jurg Ott, Jan L. Breslow, Vita Skilling, Thomas Lehner
Publikováno v:
Human Heredity. 51:8-19
Objectives: Obesity, type II diabetes, hypertension, and dyslipidemia are major causes of morbidity and mortality throughout the world. Though these disorders often cluster in individuals and families and are collectively known as syndrome X, the bas