Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stephan C. Schürer"'
Autor:
John Erol Evangelista, Daniel J B Clarke, Zhuorui Xie, Alexander Lachmann, Minji Jeon, Kerwin Chen, Kathleen M Jagodnik, Sherry L Jenkins, Maxim V Kuleshov, Megan L Wojciechowicz, Stephan C Schürer, Mario Medvedovic, Avi Ma’ayan
Publikováno v:
Nucleic Acids Research. 50:W697-W709
Millions of transcriptome samples were generated by the Library of Integrated Network-based Cellular Signatures (LINCS) program. When these data are processed into searchable signatures along with signatures extracted from Genotype-Tissue Expression
Autor:
Keith J Kelleher, Timothy K Sheils, Stephen L Mathias, Jeremy J Yang, Vincent T Metzger, Vishal B Siramshetty, Dac-Trung Nguyen, Lars Juhl Jensen, Dušica Vidović, Stephan C Schürer, Jayme Holmes, Karlie R Sharma, Ajay Pillai, Cristian G Bologa, Jeremy S Edwards, Ewy A Mathé, Tudor I Oprea
Publikováno v:
Kelleher, K J, Sheils, T K, Mathias, S L, Yang, J J, Metzger, V T, Siramshetty, V B, Nguyen, D-T, Jensen, L J, Vidovic, D, Schurer, S C, Holmes, J, Sharma, K R, Pillai, A, Bologa, C G, Edwards, J S, Mathe, E A & Oprea, T 2023, ' Pharos 2023 : an integrated resource for the understudied human proteome ', Nucleic Acids Research, vol. 51, no. D1, gkac1033, pp. D1405-D1416 . https://doi.org/10.1093/nar/gkac1033
The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them with small molecules, biologics, or other therapeutic mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d65450ea96a731b4d232b473fbf4326
https://curis.ku.dk/portal/da/publications/pharos-2023(f032f17b-c49b-4c10-9eb3-36e30874c00f).html
https://curis.ku.dk/portal/da/publications/pharos-2023(f032f17b-c49b-4c10-9eb3-36e30874c00f).html
Autor:
Jalaj Garg, Milind Mahajan, Nicole Dubois, Kristin G. Beaumont, Katherine C. Michelis, Marc R. Birtwistle, Seth I. Berger, Joseph Goldfarb, Jason C. Kovacic, David C. Thomas, Marc A. Miller, Bino Mathew, Priyanka Dhanan, Teeya Raghunandan, Evren U. Azeloglu, Ravi Iyengar, Joseph Tripodi, Himali Weerahandi, Christoph Schaniel, Rafael Dariolli, Jens Hansen, Moara Machado, Gomathi Jayaraman, Stephan C. Schürer, Colleen S. Lynch, Bin Hu, David M. Gonzalez, Dusica Vidovic, Sunita L. D’Souza, Vesna Najfeld, Arjun Singh Yadaw, Eric A. Sobie, Neelima C. Tangirala, Eric E. Schadt, Yuguang Xiong, Robert Sebra
Publikováno v:
Stem Cell Reports
Summary A library of well-characterized human induced pluripotent stem cell (hiPSC) lines from clinically healthy human subjects could serve as a useful resource of normal controls for in vitro human development, disease modeling, genotype-phenotype
PNCK, or CAMK1b, is an understudied kinase of the calcium-calmodulin dependent kinase family which recently has been identified as a marker of cancer progression and survival in several large-scale multi-omics studies. The biology of PNCK and its rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0688b5430ab3752a8e784803c8b3e0f2
https://doi.org/10.1101/2022.06.01.494277
https://doi.org/10.1101/2022.06.01.494277
Autor:
Raymond Terryn, Alexander Lachmann, Vasileios Stathias, John Paul Turner, Afoma C. Umeano, Daniel J.B. Clarke, Dusica Vidovic, John Erol Evangelista, Amar Koleti, Marcin Pilarczyk, Stephan C. Schürer, Mehdi Fazel-Najafabadi, Caty Chung, Daniel J. Cooper, Avi Ma'ayan, Mario Medvedovic
Publikováno v:
Nucleic Acids Research
The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program with the goal of generating a large-scale and comprehensive catalogue of perturbation-response signatures by utilizing a diverse collection of perturbat
Autor:
Giovanni Bocci, Noel Southall, Dusica Vidovic, Cristian Bologa, Lars Juhl Jensen, Stephan C. Schürer, Tudor I. Oprea, Jayme Holmes, Vishal B. Siramshetty, Amar Koleti, Poorva Dharkar, Dac-Trung Nguyen, Anna Waller, Jeremy J. Yang, Timothy Sheils, Keith J. Kelleher, Anton Simeonov, Stephen L. Mathias, Ewy Mathé
Publikováno v:
Sheils, T K, Mathias, S L, Kelleher, K J, Siramshetty, V B, Nguyen, D T, Bologa, C G, Jensen, L J, Vidović, D, Koleti, A, Schürer, S C, Waller, A, Yang, J J, Holmes, J, Bocci, G, Southall, N, Dharkar, P, Mathé, E, Simeonov, A & Oprea, T I 2021, ' TCRD and Pharos 2021 : mining the human proteome for disease biology ', Nucleic Acids Research, vol. 49, no. D1, pp. D1334-D1346 . https://doi.org/10.1093/nar/gkaa993
Nucleic Acids Research
Nucleic Acids Research
In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecules or biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b704a90589085c564c27e01092a99c
https://curis.ku.dk/ws/files/256214286/gkaa993_1.pdf
https://curis.ku.dk/ws/files/256214286/gkaa993_1.pdf
Autor:
Caty Chung, Nicholas A. Clark, Michele Forlin, John Paul Turner, Christopher C. Mader, Mehdi Fazel, Sherry L. Jenkins, Amar Koleti, Naim Al Mahi, John F. Reichard, Tanya T. Kelley, Alessandro D'Urso, Kathleen M. Jagodnik, Dusica Vidovic, Mario Medvedovic, Marcin Pilarczyk, Vasileios Stathias, Behrouz Shamsaei, Lily Wang, Wen Niu, Avi Ma'ayan, Stephan C. Schürer, Daniel J. Cooper, Denis Torre, Bryce K. Allen, Raymond Terryn, Juozas Vasiliauskas, Jarek Meller, Ajay Pillai
Publikováno v:
Nucleic Acids Research
The Library of Integrated Network-based Cellular Signatures (LINCS) program is a national consortium funded by the NIH to generate a diverse and extensive reference library of cell-based perturbation-response signatures, along with novel data analyti
Autor:
Rajarshi Guha, Anne Hersey, Nicolas F. Fernandez, Anna Waller, Lars Juhl Jensen, Juhee Patel, John P. Overington, Larry A. Sklar, Geetha Mandava, Dac-Trung Nguyen, Ajit Jadhav, Søren Brunak, Saurabh Mehta, Jeremy J. Yang, Subramani Mani, Noel Southall, Timothy Sheils, Guixia Liu, Dusica Vidovic, Cristian Bologa, Anneli Karlsson, Anna Gaulton, Avi Ma'ayan, Stephan C. Schürer, Tudor I. Oprea, Jayme Holmes, Oleg Ursu, Andrew D. Rouillard, Stephen L. Mathias, Anton Simeonov
Publikováno v:
Nucleic Acids Research
The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) p
Autor:
Marcin Pilarczyk, Michael J. MacCoss, Jarek Meller, Jie Zheng, Andrea Matlock, Chuming Chen, Ajay Pillai, John Paul Turner, Somchai Chutipongtanate, Jake Jaffe, Stephan C. Schürer, Wen Niu, Michal Kouril, Mehdi Fazel Najafabadi, Mario Medvedovic, Avi Ma'ayan, Jeremy L. Muhlich, Behrouz Shamsaei, Szymon Chojnacki, Karen Ross, Cathy H. Wu, Dusica Vidovic
Publikováno v:
Nucleic Acids Research
Rapid progress in proteomics and large-scale profiling of biological systems at the protein level necessitates the continued development of efficient computational tools for the analysis and interpretation of proteomics data. Here, we present the piN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db1481e8249f36ebef7b24f5b1fe799
Autor:
Avi Ma'ayan, Michael T. McManus, Larry A. Sklar, Gary L. Johnson, Brian K. Shoichet, Bryan L. Roth, Stephan C. Schürer, Tudor I. Oprea, Lily Yeh Jan
Publikováno v:
PLoS biology, vol 16, iss 12
PLoS Biology
PLoS Biology, Vol 16, Iss 12, p e3000067 (2018)
PLoS Biology
PLoS Biology, Vol 16, Iss 12, p e3000067 (2018)
In this Formal Comment, the authors of the recent publication "Large-scale investigation of the reasons why potentially important genes are ignored" maintain that it can be read as an opportunity to explore the unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f8c7c9ea54195fe41ed7bef16e9ea5
https://escholarship.org/uc/item/72c8g3s4
https://escholarship.org/uc/item/72c8g3s4