Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Natali Gulbahce"'
Autor:
Rebecca Yu Zhang, Radoje Drmanac, Huixin Xu, Yuqing Deng, Fang Chen, Quan Shi, Brock A. Peters, Zhenyu Li, Robert Chin, Weiwei Xie, Erin E. Peters, Qing Mao, Natali Gulbahce
Amniocentesis is typically performed to identify large chromosomal abnormalities within the fetus. Here we demonstrate that it is feasible to generate an accurate whole genome sequence (WGS) of a fetus from an amniotic sample. DNA from cells and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96fe5e731c30a9947791019449f0963
Autor:
R. Prates, Radoje Drmanac, Birgit Crain, Misha R. Agarwal, Brock A. Peters, Oleg Alferov, Mark A. McElwain, Rebecca Yu Zhang, Daniel M. Hayden, Rick Tearle, Natali Gulbahce, Alan S. Berkeley, Y. Tom Tang, Santiago Munné, Bahram Ghaffarzadeh Kermani
Publikováno v:
Genome Research. 25:426-434
Currently, the methods available for preimplantation genetic diagnosis (PGD) of in vitro fertilized (IVF) embryos do not detect de novo single-nucleotide and short indel mutations, which have been shown to cause a large fraction of genetic diseases.
Autor:
Robert Chin, Qing Mao, Zhenyu Li, Hope S. Rugo, Radoje Drmanac, Snezana Drmanac, Xingpeng Chen, Katharine Lee, Yuxiang Li, Brock A. Peters, Rick Tearle, Xuhao Luo, Natali Gulbahce, Daniel M. Hayden, Misha R. Agarwal, Yanxiang Chen, Emily Park, Rebecca Yu Zhang, Jia Liu, Mark Jesus M. Magbanua, Serban Ciotlos, John W. Park
Publikováno v:
Cancer research. 77(16)
Much effort has been dedicated to developing circulating tumor cells (CTC) as a noninvasive cancer biopsy, but with limited success as yet. In this study, we combine a method for isolation of highly pure CTCs using immunomagnetic enrichment/fluoresce
Publikováno v:
Nature Reviews Genetics. 12:56-68
Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene, but reflects the perturbations of the complex intracellular and intercellular network that
Autor:
Kelan G. Tantisira, Conway C. Huang, Maksim Kitsak, Benjamin A. Raby, Weiliang Qiu, Edwin K. Silverman, Scott T. Weiss, Amitabh Sharma, Nidhi Sahni, Xiaobo Zhou, Radu Dobrin, Hao Liu, Albert-László Barabási, Linh Voung, Joel Tocker, Marc Vidal, Elliot S. Barnathan, Susan Dina Ghiassian, Frédéric Baribaud, Natali Gulbahce, Tatiana Ort, Feng Guo, Derek Thibault, Jörg Menche, Reynold A. Panettieri
Publikováno v:
Human molecular genetics. 24(11)
Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved in complex diseases. Still, the detailed understanding of the molecular and physiological mechanisms through which these genes affect dise
Autor:
Alyce A. Chen, David E. Hill, Amy M. Holthaus, Theodore R. Pak, Mariet C.W. Feltkamp, Danielle Byrdsong, James A. DeCaprio, Rachel Franchi, Melissa Duarte, Saurav Singh, Manor Askenazi, Orit Rozenblatt-Rosen, Jennifer M. Spangle, Rameen Beroukhim, Larisa Litovchick, Natali Gulbahce, Sam Pevzner, Miranda Grace, Sabrina Rabello, Karl Münger, Elliott Kieff, Anne-Ruxandra Carvunis, Yun Shen, Scott B. Ficarro, Thomas Rolland, Tong Hao, Brijesh K. Garg, Michael A. Calderwood, Anna Korkhin, Renee Rubio, Jessica C. Mar, Maria Tavares, Shelly Wanamaker, Murat Tasan, Frederick P. Roth, Fieda Abderazzaq, Robert James, James T. Webber, Albert-László Barabási, Jarrod A. Marto, Mick Correll, Changyu Fan, John Quackenbush, Megha Padi, Guillaume Adelmant, Rahul C. Deo, Amélie Dricot, Marc Vidal, Jingwei Cheng, Michael E. Cusick, Jennifer Roecklein-Canfield, Eric Johannsen
Publikováno v:
Nature, 487(7408), 491-495
Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c84d9cde906583091007b3dbfeaf34
https://hdl.handle.net/1887/106305
https://hdl.handle.net/1887/106305
Autor:
Han Yan, Karin Hellner, Marc Vidal, Jarrod A. Marto, Megha Padi, Jessica C. Mar, Amy Baldwin, Amélie Dricot, Danielle Byrdsong, Nicolas Simonis, Nicholas A. Christakis, Bo Zhao, David E. Hill, Alyce A. Chen, Karl Münger, Renee Rubio, Elliott Kieff, Frederick P. Roth, John Quackenbush, Michael A. Calderwood, Albert-László Barabási, Michael E. Cusick, Rachel Franchi, Deok-Sun Lee, Pascal Braun, Natali Gulbahce, Miranda Grace, Balaji Santhanam, Orit Rozenblatt-Rosen, Jennifer Roecklein-Canfield, James A. DeCaprio, Kyung-Won Huh
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 8, Iss 6, p e1002531 (2012)
PLoS computational biology, 8 (6
PLoS Computational Biology, Vol 8, Iss 6, p e1002531 (2012)
PLoS computational biology, 8 (6
Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine w
Publikováno v:
Briefings in functional genomics. 10(5)
Despite the considerable progress in disease gene discovery, we are far from uncovering the underlying cellular mechanisms of diseases since complex traits, even many Mendelian diseases, cannot be explained by simple genotype ^ phenotype relationship
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 12, p e1000236 (2008)
PLoS Computational Biology
PLoS Computational Biology
Metabolic reactions of single-cell organisms are routinely observed to become dispensable or even incapable of carrying activity under certain circumstances. Yet, the mechanisms as well as the range of conditions and phenotypes associated with this b