Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Miloje Savic"'
Autor:
Kellie Vinal, Miloje Savic, Rachel Macmaster, Natalia Zelinskaya, S. Sunita, Graeme L. Conn, Pooja M. Desai
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:2807-2816
Methylation of bacterial 16S rRNA within the ribosomal decoding center confers exceptionally high resistance to aminoglycoside antibiotics. This resistance mechanism is exploited by aminoglycoside producers for self-protection while functionally equi
Autor:
Graeme L. Conn, Dayne M. West, Pooja M. Desai, Jack A. Dunkle, Kellie Vinal, Natalia Zelinskaya, Miloje Savic, Christine M. Dunham
Publikováno v:
Proceedings of the National Academy of Sciences. 111:6275-6280
Aminoglycosides are potent, broad spectrum, ribosome-targeting antibacterials whose clinical efficacy is seriously threatened by multiple resistance mechanisms. Here, we report the structural basis for 30S recognition by the novel plasmid-mediated am
Autor:
Sanja Bajkic, Branka Vasiljevic, Miloje Savic, Ivana Moric, Tatjana Ilic-Tomic, Sandra Vojnovic
Publikováno v:
Journal of Medical Biochemistry. 29:165-174
rRNA Methyltransferases and their Role in Resistance to AntibioticsMethyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA,
Publikováno v:
Nucleic Acids Research
X-ray crystal structures were determined of the broad-spectrum aminoglycoside-resistance A1408 16S rRNA methyltransferases KamB and NpmA, from the aminoglycoside-producer Streptoalloteichus tenebrarius and human pathogenic Escherichia coli, respectiv
Publikováno v:
Nucleic Acids Research
The 16S ribosomal RNA methyltransferase enzymes that modify nucleosides in the drug binding site to provide self-resistance in aminoglycoside-producing micro-organisms have been proposed to comprise two distinct groups of S-adenosyl-l-methionine (SAM
Autor:
Branka Vasiljevic, Miloje Savic
Publikováno v:
Journal of industrial microbiologybiotechnology. 33(6)
Natural products provide a unique element of molecular diversity and biological functionality and they are still indispensable for drug discovery. The polyketides, comprising a large and structurally diverse family of bioactive natural products, have