Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Miles, C"'
Autor:
Miles C. Smith, Lalitha R. Belur, Andrea D. Karlen, Olivia Erlanson, Justin Furcich, Troy C. Lund, Davis Seelig, Kelley F. Kitto, Carolyn A. Fairbanks, Kwi Hye Kim, Nick Buss, R. Scott McIvor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101201- (2024)
Mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal disease caused by iduronate-2-sulfatase (IDS) deficiency, leading to accumulation of glycosaminoglycans (GAGs) and the emergence of progressive disease. Enzyme replacement ther
Externí odkaz:
https://doaj.org/article/a2a8c79881364444bb7633c2c34e66ec
Autor:
Gamze Kuser-Abali, Youfang Zhang, Pacman Szeto, Peinan Zhao, Samar Masoumi-Moghaddam, Clare G. Fedele, Isobel Leece, Cheng Huang, Jen G. Cheung, Malaka Ameratunga, Fumihito Noguchi, Miles C. Andrews, Nicholas C. Wong, Ralf B. Schittenhelm, Mark Shackleton
Publikováno v:
Oncogene. 42:1360-1373
Cellular heterogeneity in cancer is linked to disease progression and therapy response, although mechanisms regulating distinct cellular states within tumors are not well understood. We identified melanin pigment content as a major source of cellular
Autor:
Kelly M. Podetz-Pedersen, Kanut Laoharawee, Sajya Singh, Tam T. Nguyen, Miles C. Smith, Alexa Temme, Karen Kozarsky, R. Scott McIvor, Lalitha R. Belur
Publikováno v:
Human Gene Therapy. 34:8-18
The mucopolysaccharidoses (MPS) are a group of recessively inherited conditions caused by deficiency of lysosomal enzymes essential to the catabolism of glycosaminoglycans. MPS I is caused by deficiency of the lysosomal enzyme alpha-L-iduronidase (ID
Autor:
Miles C. Smith, Lalitha R. Belur, Andrea D. Karlen, Olivia Erlanson, Kelly M. Podetz-Pedersen, Jessica McKenzie, Jenn Detellis, Khatuna Gagnidze, Geoffrey Parsons, Nicholas Robinson, Shelby Labarre, Saumil Shah, Justin Furcich, Troy C. Lund, Hsing-Chen Tsai, R. Scott McIvor, Melissa Bonner
Publikováno v:
Human Gene Therapy. 33:1279-1292
Autor:
Michael P Smith, Emily J Rowling, Zsofia Miskolczi, Jennifer Ferguson, Loredana Spoerri, Nikolas K Haass, Olivia Sloss, Sophie McEntegart, Imanol Arozarena, Alex vonKriegsheim, Javier Rodriguez, Holly Brunton, Jivko Kmarashev, Mitchell P Levesque, Reinhard Dummer, Dennie T Frederick, Miles C Andrews, Zachary A Cooper, Keith T Flaherty, Jennifer A Wargo, Claudia Wellbrock
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1011-1029 (2017)
Abstract Approaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a “MITF‐high” phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also conta
Externí odkaz:
https://doaj.org/article/7cabb6c3861544079d79157438ec0d09
Autor:
Vicki E. Maltby, Rodney A. Lea, Katherine A. Sanders, Nicole White, Miles C. Benton, Rodney J. Scott, Jeannette Lechner-Scott
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-6 (2017)
Abstract Background Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA methylation is an ep
Externí odkaz:
https://doaj.org/article/bdbbba599a8e4f5488a9c0c919946214
Autor:
Donia Macartney-Coxson, Miles C. Benton, Ray Blick, Richard S. Stubbs, Ronald D. Hagan, Michael A. Langston
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-21 (2017)
Abstract Background Epigenetic mechanisms provide an interface between environmental factors and the genome and are known to play a role in complex diseases such as obesity. These mechanisms, including DNA methylation, influence the regulation of dev
Externí odkaz:
https://doaj.org/article/a14c6a6329f64a4094850f7d92e97eb4
Autor:
Daniel G. Hurley, Jonathan Cebon, Joseph Cursons, Andreas Behren, Matthew Anaka, Miles C. Andrews, Edmund J. Crampin
Publikováno v:
Molecular Cancer
Background In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processes such as epithelial-mesenchymal plasticity. This can be driven by miRs targeting multiple mRNA transcripts, inducing reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb94476aa043e046d2932dea649e522
Autor:
Paul Dunn, Cassie L. Albury, Neven Maksemous, Miles C. Benton, Heidi G. Sutherland, Robert A. Smith, Larisa M. Haupt, Lyn R. Griffiths
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Epilepsy is a neurological disorder characterized by an increased predisposition for seizures. Although this definition suggests that it is a single disorder, epilepsy encompasses a group of disorders with diverse aetiologies and outcomes. A genetic
Externí odkaz:
https://doaj.org/article/018577eecb6f41619c66c05871635f7d
Autor:
Miles C. Smith, Lalitha R. Belur, Andrea D. Karlen, Kelly Podetz-Pedersen, Olivia Erlanson, Kanut Laoharawee, Justin Furcich, Troy C. Lund, Yun You, Davis Seelig, Beau R. Webber, R. Scott McIvor
Publikováno v:
Molecular Genetics and Metabolism. 138:107539