Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jason K. Sicklick"'
Autor:
Hirotaka Miyashita, Razelle Kurzrock, Nicholas J. Bevins, Kartheeswaran Thangathurai, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Sean T. Glenn, Jeffrey M. Conroy, Paul DePietro, Eitan Rubin, Jason K. Sicklick, Shumei Kato
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Immune checkpoint blockade is effective for only a subset of cancers. Targeting T-cell priming markers (TPMs) may enhance activity, but proper application of these agents in the clinic is challenging due to immune complexity and heterogeneit
Externí odkaz:
https://doaj.org/article/9b9d07a8e8b84b69aa3ad5d3d41c13e8
Autor:
Justin Shaya, Shumei Kato, Jacob J. Adashek, Hitendra Patel, Paul T. Fanta, Gregory P. Botta, Jason K. Sicklick, Razelle Kurzrock
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-8 (2023)
Abstract Despite progress, 2-year pancreatic cancer survival remains dismal. We evaluated a biomarker-driven, combination/N-of-one strategy in 18 patients (advanced/metastatic pancreatic cancer) (from Molecular Tumor Board). Targeted agents administe
Externí odkaz:
https://doaj.org/article/a2de75649db9401d9bfbe553e7066915
Autor:
Jason K. Sicklick, Shumei Kato, Ryosuke Okamura, Hitendra Patel, Mina Nikanjam, Paul T. Fanta, Michael E. Hahn, Pradip De, Casey Williams, Jessica Guido, Benjamin M. Solomon, Rana R. McKay, Amy Krie, Sarah G. Boles, Jeffrey S. Ross, J. Jack Lee, Brian Leyland-Jones, Scott M. Lippman, Razelle Kurzrock
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Malignancies are molecularly complex and become more resistant with each line of therapy. We hypothesized that offering matched, individualized combination therapies to patients with treatment-naïve, advanced cancers would be fea
Externí odkaz:
https://doaj.org/article/ce82766f53714708a38b7c9764d67487
Multi-omic analysis in carcinoma of unknown primary (CUP): therapeutic impact of knowing the unknown
Autor:
Shumei Kato, Sophia Gumas, Jacob J. Adashek, Ryosuke Okamura, Suzanna Lee, Jason K. Sicklick, Razelle Kurzrock
Publikováno v:
Molecular oncology.
Carcinoma of unknown primary (CUP) is a difficult-to-manage malignancy. Multi-omic profiles and treatment outcome versus degree of precision matching was assessed. Tumors underwent next-generation sequencing (NGS) [tissue and/or blood-derived cell-fr
Autor:
Shumei Kato, Jason K. Sicklick, Razelle Kurzrock, Richard Schwab, Richard B. Lanman, Sandip Pravin Patel, Victoria M. Raymond, Scott M. Lippman, Suzanna Lee, Ryosuke Okamura, Manvita Mareboina, Paul T. Fanta, Peter Vu, Aaron M. Goodman
Publikováno v:
JCO precision oncology, vol 3, iss 3
JCO precision oncology
JCO precision oncology
Purpose To date, evidence for tissue epidermal growth factor receptor (EGFR) overexpression as a biomarker for anti-EGFR therapies has been weak. We investigated the genomic landscape of EGFR amplification in blood-derived cell-free tumor DNA (cfDNA)
Autor:
Pradip De, J. Jack Lee, Michael E. Hahn, Shumei Kato, Hitendra Patel, Jason K. Sicklick, Brian Leyland-Jones, Jessica Guido, Benjamin M. Solomon, Mina Nikanjam, Scott M. Lippman, Paul T. Fanta, Casey Williams, Sarah Boles, Rana R. McKay, Razelle Kurzrock, Jeffrey S. Ross, Ryosuke Okamura, Amy Krie
Publikováno v:
Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Background Malignancies are molecularly complex and become more resistant with each line of therapy. We hypothesized that offering matched, individualized combination therapies to patients with treatment-naïve, advanced cancers would be feasible and
Autor:
Jill P. Mesirov, Beiqun Zhao, Thomas L. Sutton, Jeremy L. Davis, Hester van Boven, Hitendra Patel, Andrew M. Blakely, Vi Nguyen, Paul T. Fanta, Petur Snaebjornsson, Santiago Horgan, Chih Min Tang, Hyunho Yoon, Jason K. Sicklick, Ashwyn K. Sharma, Winan J. van Houdt, Nikki S. IJzerman, Christopher L. Corless, Alexa de la Fuente, Michael Heinrich, Adam M. Burgoyne, Tahsin M. Khan, Maha Alkhuziem, Jorge I. de la Torre, Skye C. Mayo, Christina Cui, Neeltje Steeghs, Sudeep Banerjee, Annemarie Bruining, Shumei Kato
Publikováno v:
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 19
Clinical Cancer Research, 27(19), 5334-5342. American Association for Cancer Research Inc.
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 19
Clinical Cancer Research, 27(19), 5334-5342. American Association for Cancer Research Inc.
Purpose: Gastrointestinal stromal tumors (GIST) commonly arise in different regions of the stomach and are driven by various mutations (most often in KIT, PDGFRA, and SDHx). We hypothesized that the anatomic location of gastric GIST is associated wit
Autor:
Jessica L. Davis, Rowan Ustoy, Chih Min Tang, Sudeep Banerjee, Markku Miettinen, Jason K. Sicklick, Adam M. Burgoyne, Sangkyu Noh, Christopher L. Corless, Mayra Yebra
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-8 (2019)
Journal of translational medicine, vol 17, iss 1
Journal of Translational Medicine
Journal of translational medicine, vol 17, iss 1
Journal of Translational Medicine
Background Plexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called “benign” tumors often present with upper GI bleeding and gastric outlet obstruction. It was recently demonstrated th
Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study
Autor:
Ryosuke Okamura, Razelle Kurzrock, J. Jack Lee, Philip J. Stephens, Michael E. Hahn, Shumei Kato, Amy Krie, Jennifer Webster, Jeffrey S. Ross, Brian Leyland-Jones, David Piccioni, Pradip De, Scott M. Lippman, Maria Schwaederle, Adam Benson, Paul T. Fanta, Vincent A. Miller, Jason K. Sicklick, Casey Williams
Publikováno v:
Nature medicine, vol 25, iss 5
Nature medicine
Nature medicine
Cancer treatments have evolved from indiscriminate cytotoxic agents to selective genome- and immune-targeted drugs that have transformed outcomes for some malignancies.1 Tumor complexity and heterogeneity suggest that the “precision medicine” par
Autor:
Ryosuke Okamura, Jason K. Sicklick, Joel M. Baumgartner, Lawrence Leichman, Shumei Kato, Hitendra Patel, Scott M. Lippman, Paul T. Fanta, Razelle Kurzrock, Kaitlyn J. Kelly
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 24, iss 24
Purpose: Esophageal, gastroesophageal junction, and gastric adenocarcinoma (herein gastroesophageal adenocarcinomas) are associated with poor prognosis and limited systemic treatment options. To further understand the genomic landscape of gastroesoph