Zobrazeno 1 - 10
of 20
pro vyhledávání: '"J. Alan Diehl"'
Publikováno v:
Oncogene
Overexpression of D-type cyclins in human cancer frequently occurs as a result of protein stabilization, emphasizing the importance of identification of the machinery that regulates their ubiqutin-dependent degradation. Cyclin D3 is overexpressed in
Autor:
Kwok-K Wong, Maureen E. Murphy, Jason R. Pitarresi, Mirazul Islam, Gizem Efe, Tatiana A. Karakasheva, Jianhua Hu, Andres J. Klein-Szanto, Jinyang Li, Taiji Yamazoe, Ben Z. Stanger, Zhenyi Su, Maoting Chen, Adam J. Bass, Wei Gu, Anil K. Rustgi, Jessica C. Leung, Anna M. Chiarella, Shoji Natsugoe, Hiroshi Nakagawa, Samuel Pan, Qiaosi Tang, J. Alan Diehl
Publikováno v:
Genes Dev
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide and evolves often to lung metastasis. P53R175H (homologous to Trp53R172H in mice) is a common hot spot mutation. How metastasis is regulated by p53R175H in ESCC rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33807ec0bf0ee5cfec8bcbefa93fc57e
https://europepmc.org/articles/PMC8015716/
https://europepmc.org/articles/PMC8015716/
Autor:
Frank Chinga, Serge Y. Fuchs, Zoya Ignatova, Jiangbin Ye, Crystal S. Conn, Weixuan Fu, Constantinos Koumenis, Andrew V. Kossenkov, Carlo Salas Salinas, Ioannis I. Verginadis, Nektaria Maria Leli, Ravi K. Amaravadi, Christine Polte, Paul P. Wang, Alexandra M Monroy, Davide Ruggero, J. Alan Diehl, Feven Tameire, Rani Ojha
Publikováno v:
Nature cell biology, vol 21, iss 7
Nature cell biology
Nature cell biology
The c-Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood. Here we reveal an essential role
Autor:
Annamarie C. Dalton, Akihiro Yoshida, Breege V. Howley, Ken Noguchi, Buckley J. McCall, J. Alan Diehl, Philip H. Howe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 5, p e0177830 (2017)
PLoS ONE, Vol 12, Iss 5, p e0177830 (2017)
ILEI (FAM3C) is a secreted factor that contributes to the epithelial-to-mesenchymal transition (EMT), a cell biological process that confers metastatic properties to a tumor cell. Initially, we found that ILEI mRNA is highly expressed in melanoma met
Autor:
Yan Li, Albert C. Koong, Constantinos Koumenis, Haiyan Zhang, George J. Cerniglia, John T. Cunningham, Lori S. Hart, Alexander E. Perl, Davide Ruggero, Andrei Thomas-Tikhonenko, Bo Qiu, Amit Maity, J. Alan Diehl, Serge Y. Fuchs, Ian G. Mills, Yan Gao, Changhong Li, Souvik Dey, Feven Tameire, Stacey L. Lehman, Meixia Bi, Huayi Liu, Tatini Datta
Publikováno v:
The Journal of clinical investigation, vol 122, iss 12
The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the pathogenic state, c-Myc–induced apoptosis is bypassed via a critical, yet poorly understood escape mechanism that promotes cellular transformation and tumorig
Ubiquitin-Dependent Proteolysis in G1/S Phase Control and Its Relationship with Tumor Susceptibility
Autor:
J. Alan Diehl, Bhaskar Ponugoti
Publikováno v:
Genes & Cancer. 1:717-724
Cell division depends upon the coordinated action of positive and negative regulatory factors that ensure high fidelity replication of the genome and its equivalent separation into daughter cells following cytokinesis. The role of positive factors su
Autor:
Priya Aggarwal, Douglas I. Lin, Craig H. Bassing, Mariusz A. Wasik, Andrew B. Gladden, Matthew D. Lessie, Laura L. Pontano, Beth Nuskey, J. Alan Diehl, Andres J. Klein-Szanto, Ami Goradia, Anil K. Rustgi
Publikováno v:
Genes & Development. 21:2908-2922
Deregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative splicing, and gene amplification. Although cancer-derived cyclin D1 mutants are potent oncogenes in vitro and in vivo, the mechanisms whereby they contribute to
Autor:
Gao Zhang, Ireneusz Majsterek, Maria Cristina Garcia Paredes, Serge Y. Fuchs, Dariusz Pytel, Yuliya V. Katlinskaya, Kirk A. Staschke, Lawrence Wu, Katarzyna Mackiewicz, Meenhard Herlyn, Olga S. Chajewski, Yan Gao, Akihiro Yoshida, J. Alan Diehl, Shuo Qie
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006518 (2016)
PLoS Genetics
PLoS Genetics
The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with bo
Autor:
Terrence A. Day, Shuo Qie, Reniqua House, Viswanathan Palanisamy, David M. Neskey, Nallasivam Palanisamy, J. Alan Diehl, Mrinmoyee Majumder
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006411 (2016)
PLoS Genetics, Vol 12, Iss 9, p e1006306 (2016)
PLoS Genetics
PLoS Genetics, Vol 12, Iss 9, p e1006306 (2016)
PLoS Genetics
RNA-binding proteins (RBP) regulate numerous aspects of co- and post-transcriptional gene expression in cancer cells. Here, we demonstrate that RBP, fragile X-related protein 1 (FXR1), plays an essential role in cellular senescence by utilizing mRNA
Autor:
Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, M. Celeste Simon, Daniel Ackerman, Zachary L. Quinn, Anthony A. Mancuso, Dionysios N. Giannoukos, Liping Liu, Michaela Gruber, Brian Keith, Regina M. Young
Solid tumors exhibit heterogeneous microenvironments, often characterized by limiting concentrations of oxygen (O2), glucose, and other nutrients. How oncogenic mutations alter stress response pathways, metabolism, and cell survival in the face of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c91ee20ceb94e817bf06cf919e0a86
https://europepmc.org/articles/PMC3672646/
https://europepmc.org/articles/PMC3672646/