Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Huwate Yeerna"'
Autor:
Paul Riviere, Amélie Boichard, Pablo Tamayo, Razelle Kurzrock, Timothy V. Pham, Huwate Yeerna, Aaron M. Goodman
Publikováno v:
Molecular Oncology, Vol 14, Iss 8, Pp 1680-1694 (2020)
Molecular Oncology
Molecular Oncology
Hydrophobic neoantigens are more immunogenic because they are better presented by the major histocompatibility complex and better recognized by T cells. Tumor cells can evade the immune response by expressing checkpoints such as programmed death liga
Autor:
Anshuman Panda, Huwate Yeerna, Anupama Yadav, Tyler Klecha, Hossein Khiabanian, Markus Lux, Shridar Ganesan, Pablo Tamayo, Gyan Bhanot, Sebastian Doniach, Alexander Schulz, Michael Biehl, Amartya Singh
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 48(13), 7079-7098. Oxford University Press
Nucleic Acids Research, 48(13), 7079-7098. Oxford University Press
We give results from a detailed analysis of human Ribosomal Protein (RP) levels in normal and cancer samples and cell lines from large mRNA, copy number variation and ribosome profiling datasets. After normalizing total RP mRNA levels per sample, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61dab1c299ed9b01b4482a17c6f6161
https://doi.org/10.1093/nar/gkaa485
https://doi.org/10.1093/nar/gkaa485
Autor:
Bradford Siegele, Yardena Samuels, J. Guy Lyons, J. Silvio Gutkind, Vachan Vadmal, Moraima Zaida, Zhiyong Wang, Lynn Vitale-Cross, Pablo Tamayo, Huwate Yeerna, Kun-Liang Guan, Alfredo A. Molinolo, Daniel Martin, Sok Ching Cheong, Juan Luis Callejas Valera, Ramiro Iglesias-Bartolome, Scott M. Lippman, Rick F. Thorne, Xiaodong Feng, Toshiro Moroishi, Maria Sol Degese
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature communications, vol 9, iss 1
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications
Dysregulation of the Hippo signaling pathway and the consequent YAP1 activation is a frequent event in human malignancies, yet the underlying molecular mechanisms are still poorly understood. A pancancer analysis of core Hippo kinases and their candi
Autor:
Dinh Diep, Brian M. Reilly, Tiffany N. Tanaka, Pablo Tamayo, Rafael Bejar, Kun Zhang, Huwate Yeerna
Publikováno v:
Blood advances, vol 3, iss 19
Recurrent mutations implicate several epigenetic regulators in the early molecular pathobiology of myelodysplastic syndromes (MDS). We hypothesized that MDS subtypes defined by DNA methylation (DNAm) patterns could enhance our understanding of MDS di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3602f3d486f3c57fdf60115d7c1a8576
https://escholarship.org/uc/item/19d4b7cd
https://escholarship.org/uc/item/19d4b7cd
Autor:
Lisa Kim, Pablo Tamayo, Vincent A. Miller, Catriona Jamieson, Razelle Kurzrock, Matthew J. Wieduwilt, Aaron M. Goodman, Tariq I. Mughal, Jo-Anne Vergilio, Michael Y. Choi, Natalie Galanina, Huwate Yeerna, Carolyn Mulroney, Rafael Bejar
Publikováno v:
Cancers, Vol 11, Iss 1, p 11 (2018)
Cancers
Cancers, vol 11, iss 1
Volume 11
Issue 1
Cancers
Cancers, vol 11, iss 1
Volume 11
Issue 1
Background: The translation of genomic discoveries to the clinic is the cornerstone of precision medicine. However, incorporating next generation sequencing (NGS) of hematologic malignancies into clinical management remains limited. Methods: We descr
Autor:
Robert W. Sobol, Justin K. Huang, Trey Ideker, Jianfeng Li, Jia L. Xu, Ana Bojorquez-Gomez, Andrew M. Gross, James Jensen, Leonie Kollenstart, Rohith Srivas, Daniel Pekin, John Paul Shen, Haico van Attikum, Kristin Klepper, Vignesh Sivaganesh, Chih Cheng Yang, Su Ming Sun, Pedro Aza-Blanc, Huwate Yeerna, Katherine Licon
Publikováno v:
Molecular Cell, 63(3), 514-525
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8619741cd89b289b24df77a20c39353
https://hdl.handle.net/1887/113262
https://hdl.handle.net/1887/113262
Autor:
Jonathan Liang, Andrew J. Aguirre, David A. Barbie, Jong Wook Kim, Huwate Yeerna, Karina Meneses-Cime, Pablo Tamayo, Emily Damato, Mahmoud Ghandi, Jason Park, Kate Medetgul-Ernar, Chen-Hsiang Yeang, Michelle Stewart, Barbara A. Weir, Aviad Tsherniak, Jill P. Mesirov, David Thomas, Gabriella Alexe, William C. Hahn, Eliezer M. Van Allen, Taylor B. Cavazos, Paul A. Clemons, Russell W. Jenkins, Jesse S. Boehm, John G. Doench, Ofir Cohen, Stephanie Ting, Shunsuke Kitajima, Levi A. Garraway, Arthur Liberzon, Omar O. Abudayyeh, David J. Konieczkowski, John H McDermott, Clarence K. Mah, Aravind Subramanian, Francisca Vazquez
Publikováno v:
Cell systems, vol 5, iss 2
The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the functional consequences of thesealterations is necessary to guide appropriatetherapeutic st
Autor:
Barbara A. Weir, Ramya Rangan, Andrew J. Aguirre, Jill P. Mesirov, Aviad Tsherniak, Jesse S. Boehm, Pablo Tamayo, Huwate Yeerna, Mahmoud Ghandi, William Kim, William C. Hahn, Francisca Vazquez
Publikováno v:
Cancer Research. 77:1555-1555
We present a methodology to fit statistical models of cell-viability profiles from RNAi-gene knockdowns. This method allows us to classify genes according to the degree of skewness in their viability distributions. The set of genes with the highest d