Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Guo Cheng"'
Autor:
Zhengyun Xiao, Guo Cheng, Yang Jiao, Chen Pan, Ran Li, Danmei Jia, Jing Zhu, Chao Wu, Min Zheng, Junling Jia
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-22 (2018)
Abstract Current single-cell RNA-seq approaches are hindered by preamplification bias, loss of strand of origin information, and the inability to observe small-RNA and mRNA dual transcriptomes. Here, we introduce a single-cell holo-transcriptome sequ
Externí odkaz:
https://doaj.org/article/18ccf12f0d2d491586f690fc4b00fe12
Autor:
Guo Cheng, Patrick Ho-Yu Chung, Edwin Kin-Wai Chan, Man-Ting So, Pak-Chung Sham, Stacey S. Cherny, Paul Kwong-Hang Tam, Maria-Mercè Garcia-Barceló
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-9 (2017)
Abstract Background Biliary Atresia (BA) is rare and genetically complex, and the pathogenesis is elusive. The disease course is variable and can represent heterogeneity, which hinders effective disease management. Deciphering the BA phenotypic varia
Externí odkaz:
https://doaj.org/article/98007cc650c84dbca87933c317603a91
Autor:
Clara Sze-Man Tang, Guo Cheng, Man-Ting So, Benjamin Hon-Kei Yip, Xiao-Ping Miao, Emily Hoi-Man Wong, Elly Sau-Wai Ngan, Vincent Chi-Hang Lui, You-Qiang Song, Danny Chan, Kenneth Cheung, Zhen-Wei Yuan, Liu Lei, Patrick Ho-Yu Chung, Xue-Lai Liu, Kenneth Kak-Yuen Wong, Christian R. Marshall, Stephen Scherer, Stacey S. Cherny, Pak-Chung Sham, Paul Kwong-Hang Tam, Maria-Mercè Garcia-Barceló
Publikováno v:
PLoS Genetics, Vol 8, Iss 5 (2012)
Externí odkaz:
https://doaj.org/article/fc0f1f3006d949558b6a043db307c4ed
Autor:
Clara Sze-Man Tang, Guo Cheng, Man-Ting So, Benjamin Hon-Kei Yip, Xiao-Ping Miao, Emily Hoi-Man Wong, Elly Sau-Wai Ngan, Vincent Chi-Hang Lui, You-Qiang Song, Danny Chan, Kenneth Cheung, Zhen-Wei Yuan, Liu Lei, Patrick Ho-Yu Chung, Xue-Lai Liu, Kenneth Kak-Yuen Wong, Christian R Marshall, Stephen W Scherer, Stacey S Cherny, Pak-Chung Sham, Paul Kwong-Hang Tam, Maria-Mercè Garcia-Barceló
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002687 (2012)
Hirschsprung disease (HSCR) is a congenital disorder characterized by aganglionosis of the distal intestine. To assess the contribution of copy number variants (CNVs) to HSCR, we analysed the data generated from our previous genome-wide association s
Externí odkaz:
https://doaj.org/article/e39739e82bd9432eb791bfa1368ea972
Autor:
Renying Wang, Peijing Zhang, Jingjing Wang, Lifeng Ma, Weigao E, Shengbao Suo, Mengmeng Jiang, Jiaqi Li, Haide Chen, Huiyu Sun, Lijiang Fei, Ziming Zhou, Yincong Zhou, Yao Chen, Weiqi Zhang, Xinru Wang, Yuqing Mei, Zhongyi Sun, Chengxuan Yu, Jikai Shao, Yuting Fu, Yanyu Xiao, Fang Ye, Xing Fang, Hanyu Wu, Qile Guo, Xiunan Fang, Xia Li, Xianzhi Gao, Dan Wang, Peng-Fei Xu, Rui Zeng, Gang Xu, Lijun Zhu, Lie Wang, Jing Qu, Dan Zhang, Hongwei Ouyang, He Huang, Ming Chen, Shyh-Chang NG, Guang-Hui Liu, Guo-Cheng Yuan, Guoji Guo, Xiaoping Han
Publikováno v:
Nucleic Acids Research. 51:501-516
Individual cells are basic units of life. Despite extensive efforts to characterize the cellular heterogeneity of different organisms, cross-species comparisons of landscape dynamics have not been achieved. Here, we applied single-cell RNA sequencing
Autor:
Mohammed Muzamil Khan, Guo-Cheng Yuan, Ruben Dries, Jiaji Chen, Natalie del Rossi, Adriana Sistig
Publikováno v:
Genome Res
Spatial transcriptomics is a rapidly growing field that promises to comprehensively characterize tissue organization and architecture at the single-cell or subcellular resolution. Such information provides a solid foundation for mechanistic understan
Autor:
Qiuming Yao, Daniel E. Bauer, Jonathan Y. Hsu, Stuart H. Orkin, Qian Zhu, Luca Pinello, Yan Kai, Phraew Sakon, Guo-Cheng Yuan, Nan Liu, Shuqian Xu
Publikováno v:
Nature genetics
Nat Genet
Nat Genet
BCL11A, the major regulator of fetal hemoglobin (HbF, α2γ2) level, represses γ-globin expression through direct promoter binding in adult erythroid cells in a switch to adult hemoglobin (HbA, α2β2). To uncover how BCL11A initiates repression, we
Autor:
Wenqing Cai, Hye Ji Cha, Ming Zhu, Yingli Han, Bin E. Li, Yan Kai, Fei Chen, Stuart H. Orkin, Grace Y Li, Jialiang Huang, Guo-Cheng Yuan
Publikováno v:
Genome Biology
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
BackgroundSuper-enhancers are clusters of enhancer elements that play critical roles in the maintenance of cell identity. Current investigations on super-enhancers are centered on the established ones in static cell types. How super-enhancers are est
Autor:
Yan Chen, Pei-Chao Wang, Shuai-Shuai Zhang, Jun Yang, Guo-Cheng Li, Ling-Qiao Huang, Chen-Zhu Wang
Publikováno v:
PLOS Genetics. 18:e1010455
Many plant secondary substances are feeding deterrents for insects and play a key role in the selection of host plants. The taste sensilla of phytophagous insects contain gustatory sensory neurons sensitive to deterrents but the molecular basis of de
Autor:
Chen-Zhu Wang, Ling-Qiao Huang, Jun Yang, Hao Guo, Nan Ji Jiang, Guo Cheng Li, Rui Tang, Joop J. A. van Loon
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009527 (2021)
Plos Genetics, 17(7)
Plos Genetics 17 (2021) 7
PLoS Genetics
Plos Genetics, 17(7)
Plos Genetics 17 (2021) 7
PLoS Genetics
Glucosinolates are token stimuli in host selection of many crucifer specialist insects, but the underlying molecular basis for host selection in these insects remains enigmatic. Using a combination of behavioral, electrophysiological, and molecular m