Zobrazeno 1 - 10
of 19
pro vyhledávání: '"George Kassiotis"'
Autor:
Jef D. Boeke, Kathleen H. Burns, Katherine B. Chiappinelli, Marie Classon, John M. Coffin, Daniel D. DeCarvalho, Joseph D. Dukes, Benjamin Greenbaum, George Kassiotis, Sarah K. Knutson, Arnold J. Levine, Avindra Nath, Sophie Papa, Daniel Rios, John Sedivy, David T. Ting
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In November 2022 the first Dark Genome Symposium was held in Boston, USA. The meeting was hosted by Rome Therapeutics and Enara Bio, two biotechnology companies working on translating our growing understanding of this vast genetic landscape
Externí odkaz:
https://doaj.org/article/afb42101dc1c4afbabb0c6b4ea01ef97
Autor:
Jan Attig, Judith Pape, Laura Doglio, Anastasiya Kazachenka, Eleonora Ottina, George R. Young, Katey S.S. Enfield, Iker Valle Aramburu, Kevin W. Ng, Nikhil Faulkner, William Bolland, Venizelos Papayannopoulos, Charles Swanton, George Kassiotis
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Increased levels and diversity of human endogenous retrovirus (HERV) transcription characterize most cancer types and are linked with disease outcomes. However, the underlying processes are incompletely understood. Here, we show that elevated transcr
Externí odkaz:
https://doaj.org/article/394a3762490547b7bf44934409acfbbe
Autor:
Anastasiya Kazachenka, George R. Young, Jan Attig, Chrysoula Kordella, Eleftheria Lamprianidou, Emmanuela Zoulia, George Vrachiolias, Menelaos Papoutselis, Elsa Bernard, Elli Papaemmanuil, Ioannis Kotsianidis, George Kassiotis
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-18 (2019)
Abstract Background Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, s
Externí odkaz:
https://doaj.org/article/bc18ef2bdea645658e48631f6ae61c14
Autor:
Laura Doglio, Georgina H. Cornish, George Kassiotis, Tom Lesluyes, Peter Van Loo, Anastasiya Kazachenka, Thomas Tüting, Eleonora Ottina, Veera Panova, Jan Attig, Kevin Litchfield, George R. Young, James I. MacRae, Charles Swanton, Joanna Kirkpatrick
Publikováno v:
Oncogene
The ubiquitin-proteasome system maintains protein homoeostasis, underpins the cell cycle, and is dysregulated in cancer. However, the role of individual E3 ubiquitin ligases, which mediate the final step in ubiquitin-mediated proteolysis, remains inc
Autor:
A.G. Wrobel, Andreas Wack, Jack Major, William Bolland, Jan Attig, Steve Gamblin, Kevin W. Ng, George R. Young, George Kassiotis
Publikováno v:
Nature genetics
Nature Genetics
Nature Genetics
Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and a regulator of several physiological processes. ACE2 has recently been proposed to be interferon-inducible, suggesting th
Autor:
Chrysoula Kordella, Elli Papaemmanuil, George Kassiotis, Jan Attig, Menelaos Papoutselis, George R. Young, Ioannis Kotsianidis, Anastasiya Kazachenka, George Vrachiolias, Elsa Bernard, Eleftheria Lamprianidou, Emmanuela Zoulia
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-18 (2019)
Genome Medicine
Genome Medicine
BackgroundMyelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, such as 5-a
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Frontiers in Microbiology
Frontiers in Microbiology
The human genome bears evidence of extensive invasion by retroviruses and other retroelements, as well as by diverse RNA and DNA viruses. High frequency of somatic integration of the RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV
The human genome bears evidence of extensive invasion by retroviruses and other retroelements, as well as by diverse RNA and DNA viruses. High frequency of somatic integration of the RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f25c7ac27725f323ef5ae7d5544de5ce
https://doi.org/10.1101/2021.03.05.434119
https://doi.org/10.1101/2021.03.05.434119
Autor:
Peter L. Oliver, Aaron K W Ferron, Veera Panova, George Kassiotis, George R. Young, Urszula Eksmond, Jonathan P. Stoye
Publikováno v:
Molecular Biology and Evolution
The genomes of inbred mice harbor around 50 endogenous murine leukemia virus (MLV) loci, although the specific complement varies greatly between strains. The Gv1 locus is known to control the transcription of endogenous MLVs and to be the dominant de
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008605 (2020)
PLoS Pathogens
PLoS Pathogens
As obligate parasites, viruses highjack, modify and repurpose the cellular machinery for their own replication. Viral proteins have, therefore, evolved biological functions, such as signalling potential, that alter host cell physiology in ways that a