Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Gary J. Nabel"'
Autor:
Nancy S. Longo, M. Gordon Joyce, James C. Mullikin, Lawrence Shapiro, Peter D. Kwong, Han Altae-Tran, Melissa Simek, Young Do Kwon, Ivelin S. Georgiev, Mark K. Louder, Dennis R. Burton, Krisha McKee, John R. Mascola, Johannes F. Scheid, Zhenhai Zhang, Michel C. Nussenzweig, Zhongjia Yang, Mattia Bonsignori, Barton F. Haynes, Chaim A. Schramm, Jeff Skinner, Gwo-Yu Chuang, Mark Connors, Baoshan Zhang, Priyamvada Acharya, Anqi Zheng, Wayne C. Koff, Gary J. Nabel, Xueling Wu, Stephanie Moquin, Jiang Zhu, Tongqing Zhou, Timothy S. Luongo, Yongping Yang
Publikováno v:
Immunity. 39(2):245-258
SummaryAntibodies of the VRC01 class neutralize HIV-1, arise in diverse HIV-1-infected donors, and are potential templates for an effective HIV-1 vaccine. However, the stochastic processes that generate repertoires in each individual of >1012 antibod
Autor:
Sung Youl Ko, Wing Pui Kong, Will Fischer, Timothy C. Wallstrom, Beatrice H. Hahn, Barton F. Haynes, Zhi Yong Yang, Lan Wu, Bette T. Korber, Norman L. Letvin, Gary J. Nabel
Publikováno v:
Journal of Virology. 83:2201-2215
An effective AIDS vaccine must control highly diverse circulating strains of human immunodeficiency virus type 1 (HIV-1). Among HIV-1 gene products, the envelope (Env) protein contains variable as well as conserved regions. In this report, an informa
Autor:
David Hawkes, Melissa K. Hill, Johnson Mak, John A Marshall, Caroline P Keating, Ann C. Palmenberg, Catherine Isel, Gary J. Nabel, Redmond P. Smyth, Shu-Yun Le, Roland Marquet
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2009, 37 (3), pp.945-56. ⟨10.1093/nar/gkn1015⟩
Nucleic Acids Research, Oxford University Press, 2009, 37 (3), pp.945-56. ⟨10.1093/nar/gkn1015⟩
International audience; The bias of A-rich codons in HIV-1 pol is thought to be a record of hypermutations in viral genomes that lack biological functions. Bioinformatic analysis predicted that A-rich sequences are generally associated with minimal l
Autor:
Norman L. Letvin, Beatrice H. Hahn, Barton F. Haynes, Gary J. Nabel, Mark Muldoon, Bette T. Korber, Dan H. Barouch, Sampa Santra, Feng Gao
Publikováno v:
Proceedings of the National Academy of Sciences. 105:10489-10494
One of the major challenges that must be met in developing an HIV-1 vaccine is devising a strategy to generate cellular immunity with sufficient breadth to deal with the extraordinary genetic diversity of the virus. Amino acids in the envelopes of vi
Autor:
Madhu Prabhakaran, Masaru Kanekiyo, Daniel Lingwood, Adam K. Wheatley, Sandeep Narpala, Rodrigo Matus-Nicodemos, James R R Whittle, Barney S. Graham, Gary J. Nabel, Adrian B. McDermott, Hadi M. Yassine, Julie E. Ledgerwood, Richard A. Koup, Robert T. Bailer, Steven S. Ma
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(2)
Because of significant viral diversity, vaccines that elicit durable and broad protection against influenza have been elusive. Recent research has focused on the potential of highly conserved regions of the viral hemagglutinin (HA) as targets for bro
Autor:
Barbara C. Engel, Manfred Schmidt, Michael R. Betts, Gerhard Bauer, Denise A. Carbonaro, David Selander, Steven R. King, Keith Bishop, Susan Csik, Gary J. Nabel, Christof von Kalle, E M Smogorzewska, Donald B. Kohn, Richard A. Koup, Kathy Wilson, Christopher S. Choi, Joseph A. Church, Greg M. Podsakoff
Publikováno v:
Molecular Therapy. 12:77-86
Two HIV-1-infected children on antiretroviral therapy were enrolled into a clinical study of retroviral-mediated transfer of a gene that inhibits replication of HIV-1, targeting bone marrow CD34+ hematopoietic stem/progenitor cells. Two retroviral ve
Autor:
John R. Mascola, Gilad Ofek, Gwo-Yu Chuang, Peter D. Kwong, Zhi Yong Yang, Tatsiana Kirys, Kevin O. Saunders, Krisha McKee, Gary J. Nabel, Wei Shi, Ivelin S. Georgiev, Sijy O'Dell, Rebecca S. Rudicell, Mark Connors
Antibodies capable of effectively neutralizing HIV-1 generally exhibit very high levels of somatic hypermutation, both in their complementarity-determining and framework-variable regions. In many cases, full reversion of the antibody framework mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1edbd0826653281a714c02911e2aaac0
https://europepmc.org/articles/PMC4140862/
https://europepmc.org/articles/PMC4140862/
Autor:
Levent M. Akyürek, Kazunori Aoki, Zhi Yong Yang, Hong San, Gary J. Nabel, Elizabeth G. Nabel, Shriram Nallamshetty
Publikováno v:
Molecular Therapy. 3(5):779-786
Herpes simplex virus-thymidine kinase (HSV-TK) phosphorylates the prodrugs ganciclovir (GCV) and acyclovir (ACV), leading to disruption of DNA synthesis and inhibition of cell proliferation. HSV-TK vectors have been successfully employed in cardiovas
Autor:
Levent M. Akyürek, Kazunori Aoki, Gary J. Nabel, Zhi Yong Yang, Michael S. Parmacek, Hong San, Elizabeth G. Nabel
Publikováno v:
Molecular Medicine. 6:983-991
Gene transfer into vascular smooth muscle cells (vsmcs) holds promise for studying the pathogenesis of arterial disorders. However, a potential limitation of vectors with heterologous promoters is organ toxicity resulting from unrestricted transgene
Autor:
Levent M. Akyürek, Kazunori Aoki, Michael S. Parmacek, Elizabeth G. Nabel, Kwanyee Leung, Hong San, Gary J. Nabel
Publikováno v:
Molecular Therapy. 1(6):555-565
Gene transfer of Fas ligand (CD95L) using adenoviral vectors has been shown to generate apoptotic responses and potent inflammatory reactions that can be used to induce the regression of malignancies in vivo, but these vectors also cause significant