Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Di, Chen"'
Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice
Publikováno v:
Genes and Diseases, Vol 11, Iss 4, Pp 101147- (2024)
Externí odkaz:
https://doaj.org/article/160a1be79d414ead9cb9f470b8d70467
Autor:
Jin Zhang, Lingling Tong, Yuchen Liu, Xiang Li, Jiayi Wang, Ruoxin Lin, Ziyu Zhou, Yunbing Chen, Yanxi Chen, Yirong Liu, Di Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101199- (2024)
As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs, N6-methyladenosine (m6A) post-transcriptionally regulates the processing and metabolism of mRNAs involved in diverse biological processes. m6A modification is
Externí odkaz:
https://doaj.org/article/61c0d7e0e6d045f1be238f270384276c
Publikováno v:
Genes and Diseases, Vol 9, Iss 6, Pp 1639-1649 (2022)
Compared with early-onset familial AD (FAD), the heritability of most familial late-onset Alzheimer's disease (FLOAD) cases still remains unclear. However, there are few reported genetic profiles of FLOAD to date. In the present study, targeted seque
Externí odkaz:
https://doaj.org/article/719241ca0cc24e5c9285b576023e67a4
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Hearing impairment is a cardinal feature of Down syndrome (DS), but its clinical manifestations have been attributed to multiple factors. Murine models could provide mechanistic insights on various causes of hearing loss in DS. To investigate mechani
Externí odkaz:
https://doaj.org/article/775fe0127b654807a470ff617fc72d58
Autor:
Yirong Jin, Suzhen Yang, Xiaoliang Gao, Di Chen, Tingting Luo, Song Su, Yanting Shi, Gang Yang, Lei Dong, Jie Liang
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
DEAD-box helicase 27 (DDX27) was previously identified as an important mediator during carcinogenesis, while its role in gastric cancer (GC) is not yet fully elucidated. Here, we aimed to investigate the mechanism and clinical significance of DDX27 i
Externí odkaz:
https://doaj.org/article/4f09c19e8d8e4f89b65b6e8a5d9a5b4f
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Background DNA methylation is a common chemical modification of DNA in the carcinogenesis of hepatocellular carcinoma (HCC). Methods In this bioinformatics analysis, 348 liver cancer samples were collected from the Cancer Genome Atlas (TCGA)
Externí odkaz:
https://doaj.org/article/bbb008b9ac624326b56b3c0602cab591
Autor:
Jing Hu, Lu‐jiao Li, Wen‐bin Zheng, Di‐chen Zhao, Ou Wang, Yan Jiang, Xiao‐ping Xing, Mei Li, Weibo Xia
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 12, Pp n/a-n/a (2020)
Abstract Background Osteogenesis imperfecta (OI) is a phenotypically and genetically heterogeneous bone disease characterized by bone fragility and recurrent fractures. X‐linked inherited OI with mutation in PLS3 is so rare that its genotype–phen
Externí odkaz:
https://doaj.org/article/efb8c0809faa4565b3ab112bcb672bdb
Autor:
Wen‐bin Zheng, Lu‐jiao Li, Di‐chen Zhao, Ou Wang, Yan Jiang, Wei‐bo Xia, Xiao‐ping Xing, Mei Li
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 3, Pp n/a-n/a (2020)
Abstract Background Spondyloepiphyseal dysplasia congenita (SEDC) is an extremely rare inherited chondrodysplasia characterized by abnormal epiphyses, short stature, and flattened vertebral bodies. We investigate the phenotypes and the disease‐asso
Externí odkaz:
https://doaj.org/article/ff8940886cf643a5858599f670ac7e65
Autor:
Yajun Meng, Ze Jin, Mengmeng Wang, Di Chen, Mengpei Zhu, Yumei Huang, Shang Xia, Zhifang Xiong
Publikováno v:
Biochemical Genetics.
Autor:
Xuqiang Zhu, Di Chen, Yiyu Sun, Shuo Yang, Weiguang Wang, Bing Liu, Peng Gao, Xueyuan Li, Lixin Wu, Siqi Ma, Wenyang Lin, Jiwei Ma, Dongming Yan
Publikováno v:
BMC Cancer. 23
Background Glioma is characterized by high morbidity, high mortality, and poor prognosis. Despite tremendous advances in the treatment of glioma, the prognosis of patients with glioma is still unsatisfactory. There is an urgent need to discover novel