Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andrew F. Taylor"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Repair of broken DNA by homologous recombination requires coordinated enzymatic reactions to prepare it for interaction with intact DNA. The multiple activities of enterobacterial RecBCD helicase-nuclease are coordinated by Chi recombination hotspots
Publikováno v:
Nucleic Acids Research
Coordinating multiple activities of complex enzymes is critical for life, including transcribing, replicating and repairing DNA. Bacterial RecBCD helicase–nuclease must coordinate DNA unwinding and cutting to repair broken DNA. Starting at a DNA en
Publikováno v:
Nucleic Acids Research
Homologous recombination occurs especially frequently near special chromosomal sites called hotspots. In Escherichia coli, Chi hotspots control RecBCD enzyme, a protein machine essential for the major pathway of DNA break-repair and recombination. Re
Publikováno v:
Molecular Cell. 31(3):324-336
Saccharomyces cerevisiae RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, are implicated in processing joint molecule (JM) recombination intermediates. We show that cells lacking either enzyme frequently experience chromosome segregation
Publikováno v:
Genes & Development. 18:1618-1629
We show that intracellular transcription of G-rich regions produces novel DNA structures, visible by electron microscopy as large (150–500 bp) loops. These G-loops are formed cotranscriptionally, and they contain G4 DNA on one strand and a stable R
Publikováno v:
Genetics. 161:483-492
The heterotrimeric RecBCD enzyme of Escherichia coli is required for the major pathway of double-strand DNA break repair and genetic exchange. Assembled as a heterotrimer, the enzyme has potent nuclease and helicase activity. Analysis of recC nonsens
Publikováno v:
Trends in Genetics. 14:485-488
We thank R. Mau (University of Wisconsin) for sending us files of E. coli ORFs and frequencies of codon use; an anonymous reviewer for pointing out an error in one of our calculations; V. Biaudet, M. El Karoui and A. Gruss for communicating before pu
Autor:
Neil Hunter, Andrew F. Taylor, Gareth A. Cromie, Gerald R. Smith, Randy W. Hyppa, Kseniya Zakharyevich
Publikováno v:
Cell. 127(6)
SummaryCrossing-over between homologous chromosomes facilitates their accurate segregation at the first division of meiosis. Current models for crossing-over invoke an intermediate in which homologs are connected by two crossed-strand structures call
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e93793 (2014)
PLoS ONE, Vol 9, Iss 4, p e93793 (2014)
We have studied the physiological and genetic responses of Arabidopsis thaliana L. (Arabidopsis) to gold. The root lengths of Arabidopsis seedlings grown on nutrient agar plates containing 100 mg/L gold were reduced by 75%. Oxidized gold was subseque
Autor:
Gerald R. Smith, Andrew F. Taylor
Publikováno v:
Genesdevelopment. 13(7)
We report here an unusual mechanism for enzyme regulation: the disassembly of all three subunits of RecBCD enzyme after its interaction with a Chi recombination hot spot. The enzyme, which is essential for the major pathway of recombination in Escher