Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Holmen, Oddgeir"'
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
Autor:
Nielsen, Jonas B, Rom, Oren, Surakka, Ida, Graham, Sarah E, Zhou, Wei, Roychowdhury, Tanmoy, Fritsche, Lars G, Gagliano Taliun, Sarah A, Sidore, Carlo, Liu, Yuhao, Gabrielsen, Maiken E, Skogholt, Anne Heidi, Wolford, Brooke, Overton, William, Zhao, Ying, Chen, Jin, Zhang, He, Hornsby, Whitney E, Acheampong, Akua, Grooms, Austen, Schaefer, Amanda, Zajac, Gregory JM, Villacorta, Luis, Zhang, Jifeng, Brumpton, Ben, Løset, Mari, Rai, Vivek, Lundegaard, Pia R, Olesen, Morten S, Taylor, Kent D, Palmer, Nicholette D, Chen, Yii-Der, Choi, Seung H, Lubitz, Steven A, Ellinor, Patrick T, Barnes, Kathleen C, Daya, Michelle, Rafaels, Nicholas, Weiss, Scott T, Lasky-Su, Jessica, Tracy, Russell P, Vasan, Ramachandran S, Cupples, L Adrienne, Mathias, Rasika A, Yanek, Lisa R, Becker, Lewis C, Peyser, Patricia A, Bielak, Lawrence F, Smith, Jennifer A, Aslibekyan, Stella, Hidalgo, Bertha A, Arnett, Donna K, Irvin, Marguerite R, Wilson, James G, Musani, Solomon K, Correa, Adolfo, Rich, Stephen S, Guo, Xiuqing, Rotter, Jerome I, Konkle, Barbara A, Johnsen, Jill M, Ashley-Koch, Allison E, Telen, Marilyn J, Sheehan, Vivien A, Blangero, John, Curran, Joanne E, Peralta, Juan M, Montgomery, Courtney, Sheu, Wayne H-H, Chung, Ren-Hua, Schwander, Karen, Nouraie, Seyed M, Gordeuk, Victor R, Zhang, Yingze, Kooperberg, Charles, Reiner, Alexander P, Jackson, Rebecca D, Bleecker, Eugene R, Meyers, Deborah A, Li, Xingnan, Das, Sayantan, Yu, Ketian, LeFaive, Jonathon, Smith, Albert, Blackwell, Tom, Taliun, Daniel, Zollner, Sebastian, Forer, Lukas, Schoenherr, Sebastian, Fuchsberger, Christian, Pandit, Anita, Zawistowski, Matthew, Kheterpal, Sachin, Brummett, Chad M, Natarajan, Pradeep, Schlessinger, David, Lee, Seunggeun, Kang, Hyun Min, Cucca, Francesco, Holmen, Oddgeir L
Publikováno v:
Nature communications, vol 11, iss 1
Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5d0f980fbe0d617bd1e47bd91d18febe
https://escholarship.org/uc/item/4fx41254
https://escholarship.org/uc/item/4fx41254
Autor:
Justice, Anne E, Karaderi, Tugce, Highland, Heather M, Young, Kristin L, Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L, Fine, Rebecca S, Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W, Locke, Adam E, Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie CY, Heard-Costa, Nancy L, Feitosa, Mary F, Manning, Alisa K, Willems, Sara M, Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S, Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Caulfield, Mark J, Cesana, Giancarlo, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Collins, Francis S, Cook, James P, Cox, Amanda J, Crosslin, David S, Danesh, John, de Bakker, Paul IW, Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W, Dennis, Joe G, Denny, Josh C, Angelantonio, Emanuele Di, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M, Easton, Douglas F, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C, Fornage, Myriam, Fox, Caroline S, Franks, Paul W, Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L, Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T, Hayward, Caroline, Heid, Iris M, Holmen, Oddgeir L, Hovingh, G Kees, Howson, Joanna MM, Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M Arfan, Ingelsson, Erik, Jackson, Anne U, Jarvik, Gail P, Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M, Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon LR, Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S, Kovacs, Peter, Krämer, Bernhard K, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A, Lamparter, David, Lange, Leslie A, Langenberg, Claudia, Larson, Eric B, Lee, Nanette R, Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E, Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J, Luan, Jian'an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas GD, McCarthy, Mark I, Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O, Morgan, Anna, Morris, Andrew P, Müller-Nurasyid, Martina, Munroe, Patricia B, Narisu, Narisu, Nelson, Christopher P, Neville, Matt, Ntalla, Ioanna, O'Connell, Jeffrey R, Owen, Katharine R, Pedersen, Oluf, Peloso, Gina M, Pennell, Craig E, Perola, Markus, Perry, James A, Perry, John RB, Pers, Tune H, Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T, Rasheed, Asif, Raulerson, Chelsea K, Rauramaa, Rainer, Reilly, Dermot F, Reiner, Alex P, Ridker, Paul M, Rivas, Manuel A, Robertson, Neil R, Robino, Antonietta, Rudan, Igor, Ruth, Katherine S, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Schreiner, Pamela J, Schulze, Matthias B, Scott, Robert A, Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J, Small, Kerrin S, Smith, Blair H, Smith, Jennifer A, Southam, Lorraine, Spector, Timothy D, Speliotes, Elizabeth K, Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin MA, Tardif, Jean-Claude, Taylor, Kent D, Teumer, Alexander, Thompson, Deborah J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H, Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, van Duijn, Cornelia M, Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F, Vuckovic, Dragana, Wagenknecht, Lynne E, Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A, Wang, Shuai, Wareham, Nicholas J, Warren, Helen R, Waterworth, Dawn M, Wessel, Jennifer, White, Harvey D, Willer, Cristen J, Wilson, James G, Wood, Andrew R, Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M, Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M Carola, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CH, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators, Rivadeneira, Fernando, Borecki, Ingrid B, Pospisilik, J Andrew, Deloukas, Panos, Frayling, Timothy M, Lettre, Guillaume, Mohlke, Karen L, Rotter, Jerome I, Kutalik, Zoltán, Hirschhorn, Joel N, Cupples, L Adrienne, Loos, Ruth JF, North, Kari E, Lindgren, Cecilia M
Publikováno v:
Nature Genetics, 51, 3, pp. 452-469
Nature Genetics, 51, 452-469
Nature genetics, 51(3), 452-469. Nature Publishing Group
Nature Genetics
Nature genetics
Nature Genetics, 51(3), 452-469. Nature Publishing Group
Nature genetics, vol. 51, no. 3, pp. 452-469
Nat. Genet. 51, 452–469 (2019)
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T N, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Li, J, Swart, K M A, Vermeulen, S H, CHD Exome+ Consortium, Frayling, T M, Lettre, G, Mohlke, K L, Rotter, J I, Kutalik, Z, Hirschhorn, J N, Cupples, L A, Loos, R J F, North, K E & Lindgren, C M 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, pp. 452–469 . https://doi.org/10.1038/s41588-018-0334-2
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Broer, L, Burt, A A, Butterworth, A S, Caulfield, M J, Cesana, G, Chambers, J C, Chasman, D I, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Collins, F S, Cook, J P, Cox, A J, Crosslin, D S, Danesh, J, de Bakker, P I W, de Denus, S, de Mutsert, R, Dedoussis, G, Demerath, E W, Dennis, J G, Denny, J C, Di Angelantonio, E, Dörr, M, Drenos, F, Dubé, M-P, Dunning, A M, Easton, D F, Elliott, P, Evangelou, E, Farmaki, A-E, Feng, S, Ferrannini, E, Ferrieres, J, Florez, J C, Fornage, M, Fox, C S, Franks, P W, Friedrich, N, Gan, W, Gandin, I, Gasparini, P, Giedraitis, V, Girotto, G, Gorski, M, Grallert, H, Grarup, N, Grove, M L, Gustafsson, S, Haessler, J, Hansen, T, Hattersley, A T, Hayward, C, Heid, I M, Holmen, O L, Kees Hovingh, G, Howson, J M M, Hu, Y, Hung, Y-J, Hveem, K, Ikram, M A, Ingelsson, E, Jackson, A U, Jarvik, G P, Jia, Y, Jørgensen, T, Jousilahti, P, Justesen, J M, Kahali, B, Karaleftheri, M, Kardia, S L R, Karpe, F, Kee, F, Kitajima, H, Komulainen, P, Kooner, J S, Kovacs, P, Krämer, B K, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T A, Lamparter, D, Lange, L A, Langenberg, C, Larson, E B, Lee, N R, Lee, W-J, Lehtimäki, T, Lewis, C E, Li, H, Li, J, Li-Gao, R, Lin, L-A, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C-T, Liu, D J, Luan, J, Lyytikäinen, L-P, MacGregor, S, Mägi, R, Männistö, S, Marenne, G, Marten, J, Masca, N G D, McCarthy, M I, Meidtner, K, Mihailov, E, Moilanen, L, Moitry, M, Mook-Kanamori, D O, Morgan, A, Morris, A P, Müller-Nurasyid, M, Munroe, P B, Narisu, N, Nelson, C P, Neville, M, Ntalla, I, Owen, K R, O'Connell, J R, Pedersen, O, Peloso, G M, Pennell, C E, Perola, M, Perry, J A, Perry, J R B, Pers, T H, Ewing, A, Polasek, O, Raitakari, O T, Rasheed, A, Raulerson, C K, Rauramaa, R, Reilly, D F, Reiner, A P, Ridker, P M, Rivas, M A, Robertson, N R, Robino, A, Rudan, I, Ruth, K S, Saleheen, D, Salomaa, V, Samani, N J, Schreiner, P J, Schulze, M B, Scott, R A, Segura-Lepe, M, Sim, X, Slater, A J, Small, K S, Smith, B H, Smith, J A, Southam, L, Spector, T D, Speliotes, E K, Stefansson, K, Steinthorsdottir, V, Stirrups, K E, Strauch, K, Stringham, H M, Stumvoll, M, Sun, L, Surendran, P, Swart, K M A, Tardif, J-C, Taylor, K D, Teumer, A, Thompson, D J, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, B H, Tönjes, A, Torres, M, Tsafantakis, E, Tuomilehto, J, Uitterlinden, A G, Uusitupa, M, van Duijn, C M, Vanhala, M, Varma, R, Vermeulen, S H, Vestergaard, H, Vitart, V, Vogt, T F, Vuckovic, D, Wagenknecht, L E, Walker, M, Wallentin, L, Wang, F, Wang, C A, Wang, S, Wareham, N J, Warren, H R, Waterworth, D M, Wessel, J, White, H D, Willer, C J, Wilson, J G, Wood, A R, Wu, Y, Yaghootkar, H, Yao, J, Yerges-Armstrong, L M, Young, R, Zeggini, E, Zhan, X, Zhang, W, Hua Zhao, J, Zhao, W, Zheng, H, Zhou, W, Zillikens, M C, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Rivadeneira, F, Borecki, I B, Pospisilik, J A, Deloukas, P, Frayling, T M, Lettre, G, Mohlke, K L, Rotter, J I, Kutalik, Z, Hirschhorn, J N, Cupples, L A, Loos, R J F, North, K E & Lindgren, C M 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51(3), 452
T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct & ReproGen Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics . https://doi.org/10.1038/s41588-018-0334-2
CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution ', Nature Genetics, vol. xx, no. xx, xx, pp. xx . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51. Nature Publishing Group
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Christensen, C, Hansen, T, Thuesen, B H & CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51, 452-469
Nature genetics, 51(3), 452-469. Nature Publishing Group
Nature Genetics
Nature genetics
Nature Genetics, 51(3), 452-469. Nature Publishing Group
Nature genetics, vol. 51, no. 3, pp. 452-469
Nat. Genet. 51, 452–469 (2019)
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T N, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Li, J, Swart, K M A, Vermeulen, S H, CHD Exome+ Consortium, Frayling, T M, Lettre, G, Mohlke, K L, Rotter, J I, Kutalik, Z, Hirschhorn, J N, Cupples, L A, Loos, R J F, North, K E & Lindgren, C M 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, pp. 452–469 . https://doi.org/10.1038/s41588-018-0334-2
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Broer, L, Burt, A A, Butterworth, A S, Caulfield, M J, Cesana, G, Chambers, J C, Chasman, D I, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Collins, F S, Cook, J P, Cox, A J, Crosslin, D S, Danesh, J, de Bakker, P I W, de Denus, S, de Mutsert, R, Dedoussis, G, Demerath, E W, Dennis, J G, Denny, J C, Di Angelantonio, E, Dörr, M, Drenos, F, Dubé, M-P, Dunning, A M, Easton, D F, Elliott, P, Evangelou, E, Farmaki, A-E, Feng, S, Ferrannini, E, Ferrieres, J, Florez, J C, Fornage, M, Fox, C S, Franks, P W, Friedrich, N, Gan, W, Gandin, I, Gasparini, P, Giedraitis, V, Girotto, G, Gorski, M, Grallert, H, Grarup, N, Grove, M L, Gustafsson, S, Haessler, J, Hansen, T, Hattersley, A T, Hayward, C, Heid, I M, Holmen, O L, Kees Hovingh, G, Howson, J M M, Hu, Y, Hung, Y-J, Hveem, K, Ikram, M A, Ingelsson, E, Jackson, A U, Jarvik, G P, Jia, Y, Jørgensen, T, Jousilahti, P, Justesen, J M, Kahali, B, Karaleftheri, M, Kardia, S L R, Karpe, F, Kee, F, Kitajima, H, Komulainen, P, Kooner, J S, Kovacs, P, Krämer, B K, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T A, Lamparter, D, Lange, L A, Langenberg, C, Larson, E B, Lee, N R, Lee, W-J, Lehtimäki, T, Lewis, C E, Li, H, Li, J, Li-Gao, R, Lin, L-A, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C-T, Liu, D J, Luan, J, Lyytikäinen, L-P, MacGregor, S, Mägi, R, Männistö, S, Marenne, G, Marten, J, Masca, N G D, McCarthy, M I, Meidtner, K, Mihailov, E, Moilanen, L, Moitry, M, Mook-Kanamori, D O, Morgan, A, Morris, A P, Müller-Nurasyid, M, Munroe, P B, Narisu, N, Nelson, C P, Neville, M, Ntalla, I, Owen, K R, O'Connell, J R, Pedersen, O, Peloso, G M, Pennell, C E, Perola, M, Perry, J A, Perry, J R B, Pers, T H, Ewing, A, Polasek, O, Raitakari, O T, Rasheed, A, Raulerson, C K, Rauramaa, R, Reilly, D F, Reiner, A P, Ridker, P M, Rivas, M A, Robertson, N R, Robino, A, Rudan, I, Ruth, K S, Saleheen, D, Salomaa, V, Samani, N J, Schreiner, P J, Schulze, M B, Scott, R A, Segura-Lepe, M, Sim, X, Slater, A J, Small, K S, Smith, B H, Smith, J A, Southam, L, Spector, T D, Speliotes, E K, Stefansson, K, Steinthorsdottir, V, Stirrups, K E, Strauch, K, Stringham, H M, Stumvoll, M, Sun, L, Surendran, P, Swart, K M A, Tardif, J-C, Taylor, K D, Teumer, A, Thompson, D J, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, B H, Tönjes, A, Torres, M, Tsafantakis, E, Tuomilehto, J, Uitterlinden, A G, Uusitupa, M, van Duijn, C M, Vanhala, M, Varma, R, Vermeulen, S H, Vestergaard, H, Vitart, V, Vogt, T F, Vuckovic, D, Wagenknecht, L E, Walker, M, Wallentin, L, Wang, F, Wang, C A, Wang, S, Wareham, N J, Warren, H R, Waterworth, D M, Wessel, J, White, H D, Willer, C J, Wilson, J G, Wood, A R, Wu, Y, Yaghootkar, H, Yao, J, Yerges-Armstrong, L M, Young, R, Zeggini, E, Zhan, X, Zhang, W, Hua Zhao, J, Zhao, W, Zheng, H, Zhou, W, Zillikens, M C, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Rivadeneira, F, Borecki, I B, Pospisilik, J A, Deloukas, P, Frayling, T M, Lettre, G, Mohlke, K L, Rotter, J I, Kutalik, Z, Hirschhorn, J N, Cupples, L A, Loos, R J F, North, K E & Lindgren, C M 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51(3), 452
T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct & ReproGen Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics . https://doi.org/10.1038/s41588-018-0334-2
CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution ', Nature Genetics, vol. xx, no. xx, xx, pp. xx . https://doi.org/10.1038/s41588-018-0334-2
Nature Genetics, 51. Nature Publishing Group
Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, Manning, A K, Willems, S M, Sivapalaratnam, S, Abecasis, G, Alam, D S, Allison, M, Amouyel, P, Arzumanyan, Z, Balkau, B, Bastarache, L, Bergmann, S, Bielak, L F, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, C A, Bork-Jensen, J, Bottinger, E P, Bowden, D W, Brandslund, I, Christensen, C, Hansen, T, Thuesen, B H & CHD Exome+ Consortium 2019, ' Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution ', Nature Genetics, vol. 51, no. 3, pp. 452-469 . https://doi.org/10.1038/s41588-018-0334-2
Body fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site va