Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dean W. Felsher"'
Autor:
Stacey J. Adam, Renumathy Dhanasekaran, David I. Bellovin, Vinodhini Arjunan, Alekesey Yevtodiyenko, Jangho Park, Dean W. Felsher, Julia Arzeno, Anand Rajan Kd, Meital Gabay, Hanan Fernando, Sergei Gryanzov
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 850-859 (2020)
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 850-859 (2020)
The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce r
Autor:
Delaney K. Sullivan, Anthony A. Mancuso, Georgia G. Toal, Annie L. Hsieh, Brian J. Altman, Arvin M. Gouw, Dean W. Felsher, Adriane Mosley, Natalie S. Liu, Sudha Janaki Raman, Katherine Margulis, Chi V. Dang, Almut Schulze, Ling Tong, Zachary E. Stine, Richard N. Zare
Publikováno v:
Cell Metab
Summary Lipid metabolism is frequently perturbed in cancers, but the underlying mechanism is unclear. We present comprehensive evidence that oncogene MYC, in collaboration with transcription factor sterol-regulated element-binding protein (SREBP1), r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd548a92d32738f13cc9c5329d137517
https://europepmc.org/articles/PMC6911354/
https://europepmc.org/articles/PMC6911354/
Publikováno v:
Oncotarget
Oncogene inactivation in both clinical targeted therapies and conditional transgenic mouse cancer models can induce significant tumor regression associated with the robust induction of apoptosis. Here we report that in MYC-, RAS-, and BCR-ABL-induced
Autor:
Vanessa M. Dang, David I. Bellovin, Stephanie C. Casey, Yulin Li, Emelyn H. Shroff, Meital Gabay, Phuoc T. Tran, Arvin M. Gouw, Adolfo Garcia-Ocaña, Dean W. Felsher, Stacey J. Adam, Richard N. Zare, William M. Philbrick, Chi V. Dang, Livia S. Eberlin
Publikováno v:
Oncotarget
The MYC oncogene is frequently mutated and overexpressed in human renal cell carcinoma (RCC). However, there have been no studies on the causative role of MYC or any other oncogene in the initiation or maintenance of kidney tumorigenesis. Here, we sh
Autor:
Alper Yetil, Arvin M. Gouw, Benedict Anchang, Ramya Parameswaran, Stacey J. Adam, Dean W. Felsher, Sylvia K. Plevritis, Jan van Riggelen, Tahera Zabuawala
Publikováno v:
Oncotarget
MYC-induced T-ALL exhibit oncogene addiction. Addiction to MYC is a consequence of both cell-autonomous mechanisms, such as proliferative arrest, cellular senescence, and apoptosis, as well as non-cell autonomous mechanisms, such as shutdown of angio
Autor:
Vivek Kaimal, Ian Lai, Meital Gabay-Ryan, Dean W. Felsher, Adriane Mosley, Virginie Baylot, Priya Karmali, Xinqiang Huang, Renumathy Dhanasekaran, Sonya Zabludoff, Jian Li
Publikováno v:
Oncotarget
Hepatocellular carcinoma (HCC) remains a significant clinical challenge with few therapeutic options. Genomic amplification and/or overexpression of the MYC oncogene is a common molecular event in HCC, thus making it an attractive target for drug the
Publikováno v:
The Molecular Basis of Human Cancer ISBN: 9781934115183
Cancer is a complex and multistep process whereby an individual cell acquires a series of mutant gene products culminating in a spectrum of pathophysiologic features including relentless proliferation, growth, blocked differentiation, the inappropria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4369dd0a62aab5d59708ce3ade4ffee
https://doi.org/10.1007/978-1-59745-458-2_8
https://doi.org/10.1007/978-1-59745-458-2_8
Autor:
Emelyn H. Shroff, Richard H. Perry, Ali I. Ismail, David I. Bellovin, Dean W. Felsher, Tahera Zabuawala, Richard N. Zare
Publikováno v:
Analytical Chemistry. 85:4259-4262
We apply desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of genetically modified tissues from a conditional transgenic mouse model of MYC-induced hepatocellular carcinoma (HCC). This uni
Autor:
Corrine R. Davis, Mark A. Kay, Theresa A. Storm, Lora S Wang, Joyce S. Lee, Kathleen Börner, Shelly Beer, Huishan Koh, Dirk Grimm, Kimberly Komatsubara, Dean W. Felsher, David I. Bellovin
Publikováno v:
Molecular Therapy. 18(1):161-170
Short hairpin RNAs (shRNAs) have emerged as a novel therapeutic modality, but there is increasing concern over nonspecific effects in vivo. Here, we used viral vectors to express shRNAs against endogenous p53 in livers of conditional MYC-transgenic m
Autor:
Constadina Arvanitis, Dean W. Felsher, Jeffrey R. Tseng, Sanjiv S. Gambhir, Pavan K. Bendapudi
Publikováno v:
Cancer Biology & Therapy. 7:1947-1951
Osteosarcoma is one of the most common pediatric cancers. Accurate imaging of osteosarcoma is important for proper clinical staging of the disease and monitoring of the tumor's response to therapy. The MYC oncogene has been commonly implicated in the