Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brian O'Connell"'
Publikováno v:
Virology. 313(2):460-472
Classically, the 5′ and 3′ long terminal repeats (LTRs) are considered necessary but not sufficient for retroviral integration. Recently, we reported that inclusion of these and additional elements from Moloney murine leukemia virus (MoMLV) facil
Publikováno v:
Human Gene Therapy. 12:2215-2223
Adenoviral vectors efficiently deliver exogenous genes to salivary glands. There are two general epithelial cell types, with very different functions, in salivary glands--acinar and ductal. To determine if gene expression can be restricted in vivo to
Publikováno v:
Nature Biotechnology. 18:176-180
A replication-deficient recombinant adenovirus encoding luciferase was constructed using 5' and 3' long terminal repeat (LTR) sequences of the Moloney murine leukemia virus. Gene expression was observed in cultured cells in vitro and in submandibular
Autor:
Lorena Baccaglini, Hilda Oweisy, A.T.M. Shamsul Hoque, Brian O'Connell, Virginia R. Braddon, Bruce J. Baum, Di Sun, Anne C. O'Connell, Laurie L. Herscher, Daniel R. Kenshalo, Philip C. Fox, Christine Delporte
Publikováno v:
Cancer gene therapy, 6 (6
Scopus-Elsevier
Scopus-Elsevier
This study evaluated the safety and efficacy of a single administration of a recombinant adenovirus encoding human aquaporin-1 (AdhAQP1) to the parotid glands of adult rhesus monkeys. In anticipation of possible clinical use of this virus to correct
Autor:
Bruce J. Baum, Brian O'Connell
Publikováno v:
Critical Reviews in Oral Biology & Medicine. 10:276-283
Considerable progress has occurred recently in transferring foreign genes to different tissues in vivo. Gene transfer to salivary glands has mirrored progress in the general field. Most salivary studies have utilized replication-deficient, recombinan
Autor:
Bruce J. Baum, Beverly Handelman, Jane C. Atkinson, Hideaki Kagami, Suzanne M. Michalek, Brian O'Connell, Shawn Yu
Publikováno v:
Human Gene Therapy. 9:305-313
This study assessed the mucosal and systemic immune responses following repetitive adenoviral vector instillation to the parotid glands. Also, we investigated the feasibility of oral tolerance induction as a rational strategy to overcome the immunolo
Publikováno v:
Human Gene Therapy. 7:1085-1093
Although replication-deficient adenoviruses can efficiently transfer genes to the salivary glands, the current vectors precipitate an immediate, transient decrease in salivary function. To study the cause of this salivary hypofunction, 10(6)-10(10) p
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 268:G1074-G1078
The internalization of DNA can be facilitated by adenovirus infection. Using the replication-deficient adenovirus, Ad-dl312, and a plasmid-based firefly luciferase gene as a reporter, we have optimized the uptake and expression of DNA in rat submandi
Publikováno v:
Cancer gene therapy. 9(1)
Activator protein-1 (AP-1) transcription factor has been linked to chemotherapeutic resistance. To assess the clinical efficacy of AP-1 inhibition toward reversing drug resistance, we have developed an adenovirus expressing a dominant negative that i
Publikováno v:
Biochemical and biophysical research communications. 274(3)
First-generation adenoviral vectors induce G(2)/M arrest and cell death at high multiplicities of infection (m.o.i.'s) in vitro. It is unclear whether this cytotoxicity is entirely adenoviral gene related or influenced in part by the encoded transgen