Zobrazeno 11 - 20
of 77
pro vyhledávání: '"Hansen, Torben"'
Autor:
Wood AR; Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, U.K., Jonsson A; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Wang N; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Diabetes & Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA., van Leewen N; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC., Kobes S; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ., Deelen J; Max Planck Institute for Biology of Ageing, Cologne, Germany., Boquete-Vilarino L; Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, U.K., Paananen J; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Stančáková A; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Boomsma DI; Department of Biological Psychology, VU University, Amsterdam, the Netherlands., de Geus EJC; Department of Biological Psychology, VU University, Amsterdam, the Netherlands., Eekhoff EMW; Diabetes Center, Internal Medicine Unit, VU University Medical Center, Amsterdam, the Netherlands., Fritsche A; Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine IV, University of Tübingen, Tübingen, Germany.; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich, University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD e.V.), Tübingen, Germany., Kramer M; Diabetes Center, Internal Medicine Unit, VU University Medical Center, Amsterdam, the Netherlands., Nijpels G; EMGO+ Institute for Health and Care Research, VU University Medical Center, Department of General Practice, Amsterdam, the Netherlands., Simonis-Bik A; Diabetes Center, Internal Medicine Unit, VU University Medical Center, Amsterdam, the Netherlands., van Haeften TW; Department of Internal Medicine, Utrecht University Medical Center, Utrecht, the Netherlands., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Bergman RN; Diabetes & Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA., Tuomilehto J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Dasman Diabetes Institute, Dasman, Kuwait.; Department of Clinical Neurosciences and Preventive Medicine, Danube University Krems, Krems, Austria.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC., Banasik K; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Groves CJ; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, U.K., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, U.K.; Oxford Biomedical Research Centre, National Institute for Health Research, Churchill Hospital, Oxford, U.K., Pearson ER; School of Medicine, University of Dundee, Dundee, U.K., Natali A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Mari A; Institute of Neuroscience, National Research Council, Padova, Italy., Buchanan TA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Diabetes & Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.; Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA., Xiang AH; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA., Gjesing AP; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Eiberg H; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Chen YD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Norris JM; Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO., Smith U; Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Wagenknecht LE; Wake Forest School of Medicine, Winston-Salem, NC., Baier L; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle, U.K. t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.; Diabetes & Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA., 't Hart LM; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.; Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Epidemiology and Biostatistics, EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands., Hanson RL; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu., Frayling TM; Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, U.K. t.m.frayling@exeter.ac.uk rhanson@phx.niddk.nih.gov lmthart@lumc.nl rwatanab@usc.edu mark.walker@newcastle.ac.uk torben.hansen@sund.ku.dk dbowden@wfubmc.edu.
Publikováno v:
Diabetes [Diabetes] 2017 Aug; Vol. 66 (8), pp. 2296-2309. Date of Electronic Publication: 2017 May 10.
Autor:
Ghouse J; The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Denmark., Have CT; The Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Skov MW; The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Denmark., Andreasen L; The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Denmark., Ahlberg G; The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Denmark., Nielsen JB; The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Denmark.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Skaaby T; Research Centre for Prevention and Health, The Capital Region, Copenhagen, Denmark., Olesen SP; The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark., Grarup N; The Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Linneberg A; Research Centre for Prevention and Health, The Capital Region, Copenhagen, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen O; The Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Vestergaard H; The Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Haunsø S; The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Svendsen JH; The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; The Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Kanters JK; Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Olesen MS; The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Denmark.
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2017 May; Vol. 19 (5), pp. 521-528. Date of Electronic Publication: 2016 Oct 06.
Autor:
Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Medina-Gomez C; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Lo KS; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Kjaer TR; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark., Fine RS; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA., Lu Y; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA., Highland HM; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.; Human Genetics Center, The University of Texas School of Public Health, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA., Rüeger S; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Thorleifsson G; deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland., Justice AE; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Lamparter D; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.; Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland., Stirrups KE; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK., Turcot V; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada., Young KL; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany., Esko T; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Karaderi T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.; McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, Missouri 63108, USA., Masca NG; Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Ng MC; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Mudgal P; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Rivas MA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Nuffield Department of Clinical Medicine, Oxford OX3 7BN, UK., Vedantam S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Guo X; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Aben KK; Netherlands Comprehensive Cancer Organisation, Utrecht, 3501 DB, The Netherlands.; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Alam DS; Centre for Control of Chronic Diseases (CCCD), Dhaka, 1212, Bangladesh., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany., Allin KH; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Allison M; Department of Family Medicine &Public Health, University of California, San Diego, La Jolla, California 92093, USA., Amouyel P; INSERM U1167, Lille, F-59019, France.; Institut Pasteur de Lille, U1167, Lille, F-59019, France.; Universite de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, F-59019, France., Appel EV; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Arveiler D; Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, F-67085, France.; Department of Public Health, University Hospital of Strasbourg, Strasbourg, 67081, France., Asselbergs FW; Department of Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK., Auer PL; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA., Balkau B; INSERM U1018, Centre de recherche en Épidemiologie et Sante des Populations (CESP), Villejuif, France., Banas B; Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany., Bang LE; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark., Benn M; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Bergmann S; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.; Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Blüher M; IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.; University of Leipzig, Department of Medicine, Leipzig, 04103, Germany., Boeing H; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany., Boerwinkle E; School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Bowden DW; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, 7100, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, 5000, Denmark., Breen G; MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London &NIHR Biomedical Research Centre for Mental Health at the Maudsley, London, SE5 8AF, UK., Brilliant MH; Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA., Broer L; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Burt AA; Department of Medicine, University of Washington, Seattle, Washington 98195, USA., Butterworth AS; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK., Carey DJ; The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK., Chambers JC; Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Chasman DI; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Chen YI; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Chowdhury R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Christensen C; Medical Department, Lillebaelt Hospital, Vejle, 7100, Denmark., Chu AY; Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.; NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA., Cocca M; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, 34100, Italy., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK., Corley J; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Galbany JC; Department of Human Genetics, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Cox AJ; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia., Cuellar-Partida G; Diamantina Institute, University of Qeensland, Brisbane, Queensland, 4072, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia., Danesh J; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK.; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Davies G; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., de Bakker PI; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., de Denus S; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada., de Groot MC; Department of Clinical Chemistry and Haematology, Division of Laboratory and Pharmacy, University Medical Center Utrecht, Utrecht, 3508 GA, The Netherlands.; Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology &Clinical Pharmacology, Utrecht University, Utrecht, 3508 TB, The Netherlands., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece., Demerath EW; Division of Epidemiology &Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA., den Hollander AI; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Dennis JG; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Di Angelantonio E; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK., Drenos F; Institute of Cardiovascular Science, University College London, London WC1E 6JF, UK.; MRC Integrative Epidemiology Unit, School of Social &Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Du M; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, Washington 98109, USA.; Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, New York 10017, USA., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Ebeling T; Department of Medicine, Oulu University Hospital, Oulu, 90029, Finland.; Research Unit of Internal Medicine, University of Oulu, Oulu, FI-90014, Finland., Edwards TL; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA., Ellinor PT; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA., Elliott P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, StLouis, Missouri 63108, USA., Feng S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Ferrannini E; CNR Institute of Clinical Physiology, Pisa, Italy.; Department of Clinical &Experimental Medicine, University of Pisa, Pisa, Italy., Ferrario MM; Research Center on Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, 21100, Italy., Ferrieres J; Toulouse University School of Medicine, Toulouse, TSA 50032 31059, France., Florez JC; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.; Department of Medicine, Harvard University Medical School, Boston, Massachusetts 02115, USA., Ford I; University of Glasgow, Glasgow G12 8QQ, UK., Fornage M; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, 901 87, Sweden., Frikke-Schmidt R; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark., Galesloot TE; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Gan W; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Gandin I; Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy., Gasparini P; Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.; Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar., Giedraitis V; Geriatrics, Department of Public Health, Uppsala University, Uppsala, 751 85, Sweden., Giri A; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA., Girotto G; Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.; Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar., Gordon SD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia., Gordon-Larsen P; Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA.; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Grove ML; School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA., Gudnason V; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.; Icelandic Heart Association, Kopavogur, 201, Iceland., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Harris KM; Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA.; Department of Sociology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Hayward C; MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., He L; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA.; Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany., Heikkilä K; Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland., Helgeland Ø; Department of Pediatrics, Haukeland University Hospital, Bergen, 5021, Norway.; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway., Hernesniemi J; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, 33521, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland., Hewitt AW; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, 3002, Australia.; Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, 6009, Australia.; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, 7000, Australia., Hocking LJ; Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.; Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, AB25 2ZD, UK., Hollensted M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Holmen OL; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, 7600, Norway., Hovingh GK; AMC, Department of Vascular Medicine, Amsterdam, 1105 AZ, The Netherlands., Howson JM; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Hoyng CB; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Huang PL; Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Hveem K; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, 7600, Norway., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Neurology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Radiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Jansson JH; Department of Public Health &Clinical Medicine, Umeå University, Umeå, SE-90185, Sweden.; Research Unit Skellefteå, Skellefteå, SE-93141, Sweden., Jarvik GP; Department of Medicine, University of Washington, Seattle, Washington 98195, USA.; Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA., Jensen GB; The Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, 2000, Denmark., Jhun MA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Jia Y; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Jiang X; Department of Preventive Medicine, Keck School of Medicine of the University of California, Los Angeles, California 90089, USA.; USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA., Johansson S; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway.; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, 5021, Norway., Jørgensen ME; National Institute of Public Health, University of Southern Denmark, Copenhagen, 1353, Denmark.; Steno Diabetes Center, Gentofte, 2820, Denmark., Jørgensen T; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Aalborg University, Aalborg, DK-9000, Denmark.; Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark., Jousilahti P; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.; The Interuniversity Cardiology Institute of the Netherlands, Utrecht, 2333, The Netherlands., Kahali B; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.; Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA., Kahn RS; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands., Kähönen M; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, 33014, Finland., Kamstrup PR; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Kaprio J; Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Karaleftheri M; Echinos Medical Centre, Echinos, Greece., Kardia SL; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK., Kee F; UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast BT12 6BJ, UK., Keeman R; Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands., Kiemeney LA; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Kitajima H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kluivers KB; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Kocher T; Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, 17475, Germany., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Kontto J; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Kooner JS; Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK.; National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Kovacs P; IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany., Kriebel J; German Center for Diabetes Research, München-Neuherberg, 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, D-85764, Germany., Kuivaniemi H; The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.; Department of Psychiatry, and Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, 7505, South Africa., Küry S; CHU Nantes, Service de Génétique Médicale, Nantes, 44093, France., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland., La Bianca M; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland., Lakka TA; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Institute of Biomedicine &Physiology, University of Eastern Finland, Kuopio, 70210, Finland., Lange EM; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Lange LA; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Langefeld CD; Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Larson EB; Department of Medicine, University of Washington, Seattle, Washington 98195, USA.; Group Health Research Institute, Seattle, Washington 98101, USA.; Department of Health Services, University of Washington, Seattle, Washington 98101, USA., Lee IT; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland., Lewis CE; Division of Preventive Medicine University of Alabama at Birmingham, Birmingham, Alabama 35205, USA., Li H; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Li J; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Lin H; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Lin LA; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA., Lin X; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Lind L; Uppsala University, Uppsala, 75185, Sweden., Lindström J; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Linneberg A; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark.; Department of Experimental Medicine, Rigshospitalet, Copenhagen, DK-2200, Denmark., Liu Y; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Liu Y; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Lophatananon A; Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Lubitz SA; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland., Mackey DA; Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, 6009, Australia., Madden PA; Department of Psychiatry, Washington University, Saint Louis, Missouri 63110, USA., Manning AK; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.; Department of Medicine, Harvard University Medical School, Boston, Massachusetts 02115, USA., Männistö S; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Marenne G; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Marten J; MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia., Mazul AL; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Meidtner K; German Center for Diabetes Research, München-Neuherberg, 85764, Germany.; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Mitchell P; Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, 2022, Australia., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Morgan A; Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy., Morris AD; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.; Department of Medicine I, Ludwig-Maximilians-Universität, Munich, 81377, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, 80802, Germany., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Nauck M; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, 17475, Germany., Nelson CP; Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, 33521, Finland., Njølstad PR; Department of Pediatrics, Haukeland University Hospital, Bergen, 5021, Norway.; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Ntalla I; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., O'Connel JR; Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Oksa H; Department of Medicine, Tampere University Hospital, Tampere, 33521, Finland., Loohuis LM; Center for Neurobehavioral Genetics, UCLA, Los Angeles, California 90095, USA., Ophoff RA; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.; Center for Neurobehavioral Genetics, UCLA, Los Angeles, California 90095, USA., Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK., Packard CJ; University of Glasgow, Glasgow G12 8QQ, UK., Padmanabhan S; University of Glasgow, Glasgow G12 8QQ, UK., Palmer CN; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Pasterkamp G; Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.; Laboratory of Experimental Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., Patel AP; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA.; Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Pattie A; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Peissig PL; Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA., Peloso GM; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA., Pennell CE; School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia., Perola M; National Institute for Health and Welfare, Helsinki, FI-00271, Finland.; University of Helsinki, Institute for Molecular Medicine (FIMM) and Diabetes and Obesity Research Program, Helsinki, FI00014, Finland.; University of Tartu, Estonian Genome Center, Tartu, Estonia, Tartu, 51010, Estonia., Perry JA; Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Perry JR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Person TN; Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA., Pirie A; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Polasek O; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.; School of Medicine, University of Split, Split, 21000, Croatia., Posthuma D; Center for Neurogenomics and Cognitive Research, Department Complex Trait Genetics, VU University, Amsterdam, 1081 HV, The Netherlands.; Neuroscience Campus Amsterdam, Department Clinical Genetics, VU Medical Center, Amsterdam, 1081 HV, The Netherlands., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland., Rasheed A; Centre for Non-Communicable Diseases, Karachi, Pakistan., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70210, Finland., Reilly DF; MRL, Merck &Co., Inc., Genetics and Pharmacogenomics, Boston, Massachusetts 02115, USA., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.; Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.; Department of Biobank Research, Umeå University, Umeå, SE-90187, Sweden., Ridker PM; Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Rioux JD; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada., Robertson N; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Rolandsson O; Department of Public Health &Clinical Medicine, Umeå University, Umeå, SE-90185, Sweden.; Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, 90185, Sweden., Rudan I; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK., Ruth KS; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Saleheen D; Centre for Non-Communicable Diseases, Karachi, Pakistan.; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Salomaa V; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Samani NJ; Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Sandow K; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Sapkota Y; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia., Sattar N; University of Glasgow, Glasgow G12 8QQ, UK., Schmidt MK; Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands., Schreiner PJ; Division of Epidemiology &Community Health University of Minnesota, Minneapolis, Minnesota 55454, USA., Schulze MB; German Center for Diabetes Research, München-Neuherberg, 85764, Germany.; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Segura-Lepe MP; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK., Shah S; Duke University, Durham, North Carolina 27703, USA., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Sivapalaratnam S; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Departement of Haematology, University of Cambridge, Cambridge CB2 OPT, UK.; Department of Vascular Medicine, AMC, Amsterdam, 1105 AZ, The Netherlands., Small KS; Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK., Smith AV; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.; Icelandic Heart Association, Kopavogur, 201, Iceland., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Southam L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK., Speliotes EK; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.; Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK., Steinthorsdottir V; deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Stumvoll M; IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.; University of Leipzig, Department of Medicine, Leipzig, 04103, Germany., Surendran P; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., 't Hart LM; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007MB, The Netherlands.; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands., Tansey KE; College of Biomedical and Life Sciences, Cardiff University, Cardiff, CF14 4EP, UK.; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Tardif JC; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada., Taylor KD; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Thorsteinsdottir U; deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Thuesen BH; Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark., Tönjes A; Center for Pediatric Research, Department for Women's and Child Health, University of Leipzig, Leipzig, 04103, Germany., Tromp G; The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, 7505, South Africa., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333, The Netherlands., Tsafantakis E; Anogia Medical Centre, Anogia, Greece., Tuomilehto J; National Institute for Health and Welfare, Helsinki, FI-00271, Finland.; Centre for Vascular Prevention, Danube-University Krems, Krems, 3500, Austria.; Dasman Diabetes Institute, Dasman, 15462, Kuwait.; Diabetes Research Group, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Tybjaerg-Hansen A; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark., Tyrer JP; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Uher R; Department of Psychiatry, Dalhousie University, Halifax B3H 4R2, Canada., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., van der Laan SW; Laboratory of Experimental Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., Van Der Leij AR; University of Amsterdam, Department of Brain &Cognition, Amsterdam, 1018 WS, The Netherlands., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., van Schoor NM; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007MB, The Netherlands., van Setten J; Department of Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Varbo A; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden., Varma R; USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA., Edwards DR; Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA., Vermeulen SH; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Vestergaard H; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Vitart V; MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Vogt TF; MRL, Merck &Co., Inc., Cardiometabolic Disease, Kenilworth, New Jersey 07033, USA., Vozzi D; Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar., Walker M; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle NE2 4HH, UK., Wang F; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Wang CA; School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia., Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Wang Y; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK., Wessel J; Departments of Epidemiology &Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health &School of Medicine, Indiana University, Indiana 46202, USA., Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA., Witte DR; Danish Diabetes Academy, Odense, 5000, Denmark.; Department of Public Health, Aarhus University, Aarhus, 8000, Denmark., Woods MO; Memorial University, Faculty of Medicine, Discipline of Genetics, St. John's, Newfoundland A1B 3V6, Canada., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Yao J; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Yao P; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Yerges-Armstrong LM; Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; GlaxoSmithKlein, King of Prussia, Pennsylvania 19406, USA., Young R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; University of Glasgow, Glasgow G12 8QQ, UK., Zeggini E; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Zhan X; Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Zhang W; Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Zhao W; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Zheng H; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Zhou W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kathiresan S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA.; Massachusetts General Hospital, Boston, Massachusetts 02114, USA., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK., Willer CJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Stefansson K; deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Borecki IB; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, StLouis, Missouri 63108, USA., Liu DJ; Department of Public Health Sciences, Institute for Personalized Medicine, the Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA., North KE; Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, North Carolina 27514, USA., Heard-Costa NL; NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Pers TH; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2200, Denmark., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford OX3 7BN, UK., Oxvig C; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark., Kutalik Z; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA.; The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Hirschhorn JN; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Departments of Pediatrics and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Lettre G; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Publikováno v:
Nature [Nature] 2017 Feb 09; Vol. 542 (7640), pp. 186-190. Date of Electronic Publication: 2017 Feb 01.
Autor:
Schmidt AF; Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK. Electronic address: amand.schmidt@ucl.ac.uk., Swerdlow DI; Institute of Cardiovascular Science, University College London, UK; Department of Medicine, Imperial College London, London, UK., Holmes MV; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK., Patel RS; Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; The Barts Heart Centre, St Bartholomew's Hospital, London, UK., Fairhurst-Hunter Z; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Lyall DM; Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK., Hartwig FP; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Horta BL; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Hyppönen E; Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK; South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Power C; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK., Moldovan M; School of Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute-EMBL Australia, Adelaide, SA, Australia., van Iperen E; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Netherlands., Hovingh GK; Department of Vascular Medicine, Academic Medical Center Amsterdam, Netherlands., Demuth I; Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany., Norman K; Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany., Steinhagen-Thiessen E; Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany., Demuth J; E.CA Economics GmbH, Berlin, Germany., Bertram L; Neuroepidemiology and Ageing Research Unit, Imperial College London, London, UK; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany., Liu T; Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany., Coassin S; Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Willeit J; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Kiechl S; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Willeit K; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Mason D; Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK., Wright J; Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK., Morris R; School of Social and Community Medicine, University of Bristol, Bristol, UK., Wanamethee G; Department of Primary Care & Population Health, University College London, UK., Whincup P; Population Health Research Institute, St George's, University of London, London, UK., Ben-Shlomo Y; School of Social and Community Medicine, University of Bristol, Bristol, UK., McLachlan S; Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Price JF; Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Kivimaki M; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK., Welch C; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK., Sanchez-Galvez A; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK., Marques-Vidal P; Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland., Nicolaides A; Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia, Cyprus., Panayiotou AG; Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus., Onland-Moret NC; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands., van der Schouw YT; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands., Matullo G; Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy., Fiorito G; Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy., Guarrera S; Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy., Sacerdote C; Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin, Italy., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Scott R; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Bobak M; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK., Malyutina S; Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia., Pająk A; Jagiellonian University Collegium Medicum, Krakow, Poland., Kubinova R; National Institute of Public Health, Prague, Czech Republic., Tamosiunas A; Lithuanian University of Health Sciences, Kaunas, Lithuania., Pikhart H; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK., Husemoen LL; Research Centre for Prevention and Health, Capital Region of Denmark, Denmark., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Simonsen KS; Research Centre for Prevention and Health, Capital Region of Denmark, Denmark., Cooper J; Centre for Cardiovascular Genetics, University College London, UK., Humphries SE; Centre for Cardiovascular Genetics, University College London, UK., Brilliant M; Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA., Kitchner T; Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA., Hakonarson H; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Carrell DS; Group Health Research Institute in Seattle, WA, USA., McCarty CA; Essentia Institute of Rural Health, Duluth, MN, USA., Kirchner HL; Center for Health Research, Geisinger Clinic, Danville, PA, USA., Larson EB; Group Health Research Institute, Seattle, WA, USA., Crosslin DR; Group Health Research Institute, Seattle, WA, USA., de Andrade M; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., Roden DM; Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA., Denny JC; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA., Carty C; George Washington University, Washington, DC, USA., Hancock S; University of Newcastle, Newcastle, NSW, Australia., Attia J; University of Newcastle, Newcastle, NSW, Australia., Holliday E; University of Newcastle, Newcastle, NSW, Australia., O'Donnell M; Population Health Research Institute, Hamilton, ON, Canada., Yusuf S; Population Health Research Institute, Hamilton, ON, Canada., Chong M; Population Health Research Institute, Hamilton, ON, Canada., Pare G; Population Health Research Institute, Hamilton, ON, Canada., van der Harst P; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Said MA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Eppinga RN; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Christen T; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands., Gustafsson S; Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lind L; Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Ingelsson E; Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Pazoki R; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands., Franco O; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands., Hofman A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands., Uitterlinden A; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands., Dehghan A; Faculty of Medicine, and Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany., Baumeister S; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany., Lerch MM; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany., Völker U; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany., Ward J; Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK., Pell JP; Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK., Smith DJ; Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK., Meade T; Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Maitland-van der Zee AH; Department of Respiratory Medicine, Academic Medical Center Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Baranova EV; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Young R; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Campbell A; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands., Grobbee DE; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands., Froguel P; Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Thuillier D; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Balkau B; Renal and Cardiovascular Epidemiology, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), INSERM U1018, Villejuif, France., Bonnefond A; Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Cariou B; I'institut du Thorax, INSERM, CNRS, University of Nantes, CHU de Nantes, Nantes, France., Smart M; Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK., Bao Y; Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK., Kumari M; Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Ridker PM; Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA., Chasman DI; Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA., Reiner AP; Department of Epidemiology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA., Lange LA; Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA., Ritchie MD; Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA., Asselbergs FW; Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands., Casas JP; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK., Keating BJ; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA., Preiss D; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK., Hingorani AD; Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address: naveed.sattar@glasgow.ac.uk.
Publikováno v:
The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2017 Feb; Vol. 5 (2), pp. 97-105. Date of Electronic Publication: 2016 Nov 29.
Autor:
Surendran P; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Drenos F; Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.; Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, Rayne Building University College London, London, UK., Young R; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Warren H; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Cook JP; Department of Health Sciences, University of Leicester, Leicester, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Manning AK; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sim X; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Barnes DR; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Witkowska K; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Staley JR; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Tragante V; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., Tukiainen T; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Yaghootkar H; Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Masca N; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK., Freitag DF; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Giannakopoulou O; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Tinker A; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Harakalova M; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Liu C; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA., Kraja AT; Division of Statistical Genomics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., Fallgaard Nielsen S; Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark., Rasheed A; Centre for Non-Communicable Diseases, Karachi, Pakistan., Samuel M; Centre for Non-Communicable Diseases, Karachi, Pakistan., Zhao W; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA., Jackson AU; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA., Southam L; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Marten J; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Huyghe JR; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Stančáková A; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Fava C; University of Lund, Department of Clinical Sciences, Malmö, Sweden.; University of Verona, Department of Medicine, Verona, Italy., Ohlsson T; University of Lund, Department of Clinical Sciences, Malmö, Sweden., Matchan A; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK., Stirrups KE; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gjesing AP; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kontto J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Perola M; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Institute of Molecular Medicine FIMM, University of Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Shaw-Hawkins S; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK., Havulinna AS; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Zhang H; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA., Donnelly LA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rayner NW; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK., Neville MJ; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Yiorkas AM; Section of Investigative Medicine, Imperial College London, London, UK.; Department of Life Sciences, Brunel University London, London, UK., Herzig KH; Institute of Biomedicine, Biocenter Oulu, University of Oulu, Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland., Kajantie E; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.; Department of Obstetrics and Gynaecology, Oulu University Hospital and University of Oulu, Oulu, Finland., Zhang W; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK., Willems SM; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Lannfelt L; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Malerba G; Section of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Soranzo N; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Trabetti E; Section of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Verweij N; University Medical Center Groningen, University of Groningen, Department of Cardiology, The Netherlands.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Moayyeri A; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Farr Institute of Health Informatics Research, Institute of Health Informatics, University College London, London, UK., Vergnaud AC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK., Poveda A; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Bilbao, Spain., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Caslake M; University of Glasgow, Glasgow, UK., de Craen AJ; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Mr. De Craen suddenly passed away January 2016., Trompet S; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Luan J; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Scott RA; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Liewald DC; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Marioni R; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, UK., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Hallmans G; Department of Biobank Research, Umeå University, Umeå, Sweden., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Biobank Research, Umeå University, Umeå, Sweden., Huffman JE; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA., Hassinen M; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Burgess S; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Vasan RS; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.; Section of Cardiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA.; Sections of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA., Felix JF; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Uria-Nickelsen M; Development Management and Planning, Pfizer Worldwide Research and Development., Malarstig A; Pfizer Worldwide Research and Development, Stockholm, Sweden., Reily DF; Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA., Hoek M; Merck Research Laboratories, Cardiometabolic Disease, Kenilworth, New Jersey, USA., Vogt T; Merck Research Laboratories, Cardiometabolic Disease, Kenilworth, New Jersey, USA.; CHDI Management/CHDI Foundation, Princeton, New Jersey, USA., Lin H; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA., Lieb W; Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany., Traylor M; Neurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Markus HF; Neurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Highland HM; University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, North Carolina, USA., Justice AE; University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, North Carolina, USA., Marouli E; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Lindström J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.; Research Unit, Kuopio University Hospital, Kuopio, Finland., Komulainen P; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Polasek O; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; Faculty of Medicine, University of Split, Croatia., Rudan I; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, UK., Jousilahti P; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Männistö S; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, UK., Langenberg C; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Wareham NJ; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Brown MJ; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Connell JM; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; The Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Ford I; University of Glasgow, Glasgow, UK., Packard CJ; University of Glasgow, Glasgow, UK., Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, Tartu, Estonia., de Boer RA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van der Meer P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands., Gambaro G; Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus - Gemelli University Hospital, Catholic University, Rome, Italy., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Lind L; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., de Bakker PI; Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Numans ME; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Christensen C; Medical Department, Lillebaelt Hospital, Vejle, Denmark., Petersen ER; Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Korpi-Hyövälti E; South Ostrobothnia Central Hospital, Seinäjoki, Finland., Oksa H; Tampere University Hospital, Tampere, Finland., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; Imperial College Healthcare NHS Trust, London, UK., Kooner JS; Department of Cardiology, Ealing Hospital, Middlesex, UK.; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Blakemore AI; Section of Investigative Medicine, Imperial College London, London, UK.; Department of Life Sciences, Brunel University London, London, UK., Franks S; Institute of Reproductive and Developmental Biology, Imperial College London, London, UK., Jarvelin MR; Department of Epidemiology and Biostatistics, Medical Research Council Public Health England Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, UK.; Centre for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Husemoen LL; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.; Department of Clinical Experimental Research, Glostrup University Hospital, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Skaaby T; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark., Thuesen B; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark., Karpe F; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK., Tuomilehto J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Dasman Diabetes Institute, Dasman, Kuwait.; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.; King Abdulaziz University, Jeddah, Saudi Arabia., Doney AS; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Morris AD; School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh, UK., Palmer CN; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Holmen OL; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.; St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway., Hveem K; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.; Department of Medicine, Levanger Hospital, Nord- Trøndelag Health Trust, Levanger, Norway., Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Tuomi T; Folkhälsan Research Centre, Helsinki, Finland; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.; Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Palotie A; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland.; Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA., Ripatti S; Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Finland.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK., Salomaa V; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Alam DS; ICDDR, B; Mohakhali, Dhaka, Bangladesh., Shafi Majumder AA; National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh., Di Angelantonio E; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Chowdhury R; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., McCarthy MI; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Poulter N; International Centre for Circulatory Health, Imperial College London, UK., Stanton AV; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Sever P; International Centre for Circulatory Health, Imperial College London, UK., Amouyel P; University of Lille, UMR1167, Risk Factors and Molecular Determinants of aging-related diseases, Lille, France.; Inserm, Lille, France.; Centre Hospitalier Universitaire Lille, Public Health, Lille, France.; Institut Pasteur de Lille, Lille, France., Arveiler D; Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Strasbourg, France., Blankenberg S; Department of General and Interventional Cardiology, University Heart Center Hamburg, Germany.; University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ferrières J; Department of Epidemiology, UMR 1027- INSERM, Toulouse University-CHU Toulouse, Toulouse, France., Kee F; Director, UKCRC Centre of Excellence for Public Health, Queens University, Belfast, Northern Ireland., Kuulasmaa K; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Veronesi G; Research Center in Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy., Virtamo J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Deloukas P; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Elliott P; Department of Epidemiology and Biostatistics, Medical Research Council Public Health England Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, UK., Zeggini E; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK., Kathiresan S; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA., Melander O; University of Lund, Department of Clinical Sciences, Malmö, Sweden., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Porteous D; Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Hayward C; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Scotland G; A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee, Edinburgh and Glasgow, UK., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Boehnke M; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Stringham HM; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Frossard P; Centre for Non-Communicable Diseases, Karachi, Pakistan., Newton-Cheh C; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, UK., Nordestgaard BG; Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Tomaszewski M; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK.; Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK., Saleheen D; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Centre for Non-Communicable Diseases, Karachi, Pakistan.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Asselbergs FW; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.; Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, UK., Lindgren CM; The Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Danesh J; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Wain LV; Department of Health Sciences, University of Leicester, Leicester, UK., Butterworth AS; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; The National Institute for Health Research Blood and Transplant Research., Howson JM; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
Publikováno v:
Nature genetics [Nat Genet] 2016 Oct; Vol. 48 (10), pp. 1151-1161. Date of Electronic Publication: 2016 Sep 12.
Autor:
Vestmar MA; Department of Neuroscience and Pharmacology, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark Section for Metabolic Receptology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Andersson EA; Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Christensen CR; Section for Metabolic Receptology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hauge M; Department of Neuroscience and Pharmacology, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark Section for Metabolic Receptology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Glümer C; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark., Linneberg A; Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Witte DR; Section for General Practice, Department of Public Health, Aarhus University, Denmark., Jørgensen ME; Steno Diabetes Center, Gentofte, Denmark Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Christensen C; Department of Internal Medicine and Endocrinology, SLB, Vejle Hospital, Vejle, Denmark., Brandslund I; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Lauritzen T; Section for General Practice, Department of Public Health, Aarhus University, Denmark., Pedersen O; Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Holst B; Department of Neuroscience and Pharmacology, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark Section for Metabolic Receptology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grarup N; Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Schwartz TW; Department of Neuroscience and Pharmacology, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark Section for Metabolic Receptology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Publikováno v:
Journal of medical genetics [J Med Genet] 2016 Sep; Vol. 53 (9), pp. 616-23. Date of Electronic Publication: 2016 Apr 11.
Autor:
Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.; Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC), affiliated with the University of Lübeck, Bolzano, Italy., Flannick J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Teslovich TM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Agarwala V; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Gaulton KJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ma C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Fontanillas P; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Moutsianas L; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., McCarthy DJ; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Rivas MA; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Perry JRB; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Blackwell TW; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rayner NW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Cingolani P; School of Computer Science, McGill University, Montreal, Quebec, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Tajes JF; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Highland HM; Human Genetics Center, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hartl C; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Chen H; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA., Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., van de Bunt M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Pearson RD; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kumar A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Gamazon ER; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Lee J; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Chen Y; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Below JE; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Chen P; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA., Go MJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Stitzel ML; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Parker SCJ; Departments of Computational Medicine & Bioinformatics and Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Varga TV; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Green T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Beer NL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Day-Williams AG; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Fingerlin T; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA., Horikoshi M; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hu C; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Huh I; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Ikram MK; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Kim BJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kim Y; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Kim YJ; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Kwon MS; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Lee J; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Lee S; Department of Statistics, Seoul National University, Seoul, Republic of Korea., Lin KH; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Maxwell TJ; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Nagai Y; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Wang X; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Welch RP; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Yoon J; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK., Barzilai N; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA., Voight BF; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Han BG; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Jenkinson CP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.; Research, South Texas Veterans Health Care System, San Antonio, Texas, USA., Kuulasmaa T; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Kuusisto J; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Manning A; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Palmer ND; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Balkau B; Centre for Research in Epidemiology and Population Health, Inserm U1018, Villejuif, France., Stančáková A; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Abboud HE; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Boeing H; German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Prabhakaran D; Centre for Chronic Disease Control, New Delhi, India., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Scott J; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Carey J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Kwan P; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Grant G; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Smith JD; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Neale BM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Purcell S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA., Butterworth AS; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Howson JMM; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lee HM; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Lu Y; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Kwak SH; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Zhao W; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Danesh J; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lam VKL; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Park KS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Aguilar D; Cardiovascular Division, Baylor College of Medicine, Houston, Texas, USA., Arya R; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore., Navarro C; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.; Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Spain., Cheng CY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Palli D; Cancer Research and Prevention Institute (ISPO), Florence, Italy., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Curran JE; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Rio Grande Valley, Brownsville, Texas, USA., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Farook VS; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Fowler SP; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Griswold M; Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Hale DE; Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA., Hicks PJ; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Khor CC; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Division of Human Genetics, Genome Institute of Singapore, ASTAR, Singapore., Kumar S; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Rio Grande Valley, Brownsville, Texas, USA., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Thuillier D; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Lim WY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Liu J; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Division of Human Genetics, Genome Institute of Singapore, ASTAR, Singapore., van der Schouw YT; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore., Musani SK; Jackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi, USA., Puppala S; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Yengo L; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Tan ST; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK., Taylor HA Jr; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Thameem F; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Wilson G Sr; College of Public Services, Jackson State University, Jackson, Mississippi, USA., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; The Eye Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore., Njølstad PR; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway., Levy JC; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Schwarzmayr T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Fadista J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Surdulescu GL; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Herder C; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wieland T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Christensen C; Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark., Koistinen HA; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Doney ASF; Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK., Kinnunen L; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Esko T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA., Farmer AJ; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Hakaste L; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Hodgkiss D; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Kravic J; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Hollensted M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jørgensen ME; Steno Diabetes Center, Gentofte, Denmark., Jørgensen T; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Public Health, Institute of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Ladenvall C; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Justesen JM; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Kriebel J; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Rathmann W; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Lannfelt L; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Lauritzen T; Department of Public Health, Section of General Practice, Aarhus University, Aarhus, Denmark., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Melander O; Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Lund University, Malmö, Sweden., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Orho-Melander M; Department of Clinical Sciences, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden., Qi L; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Qi Q; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, USA., Roden M; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Swift A; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Rosengren AH; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Stirrups K; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Blancher C; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Carneiro MO; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Maguire J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Poplin R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Shakir K; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Fennell T; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., DePristo M; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., de Angelis MH; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Gjesing AP; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jun G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Nilsson P; Department of Clinical Sciences, Medicine, Lund University, Malmö, Sweden., Murphy J; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Onofrio R; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Thorand B; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Meisinger C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Hu FB; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA., Isomaa B; Folkhälsan Research Centre, Helsinki, Finland.; Department of Social Services and Health Care, Jakobstad, Finland., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Liang L; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA., Peters A; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Huth C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., O'Rahilly SP; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rauramaa R; Foundation for Research in Health, Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Tuomilehto J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Center for Vascular Prevention, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), University Hospital LaPaz, Autonomous University of Madrid, Madrid, Spain.; National Institute for Health and Welfare, Helsinki, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Department of Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Syvänen AC; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, USA., Bharadwaj D; Functional Genomics Unit, CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi, India., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea., Chandak GR; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India., Chan JCN; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Chia KS; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Daly MJ; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Ebrahim SB; Centre for Chronic Disease Control, New Delhi, India., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Jablonski KA; The Biostatistics Center, The George Washington University, Rockville, Maryland, USA., Lehman DM; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Jia W; Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Pollin TI; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, and Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sandhu M; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Tandon N; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India., Froguel P; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Barroso I; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Life Sciences Institute, National University of Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, USA., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., DeFronzo RA; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA., Grallert H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Walker M; The Medical School, Institute of Cellular Medicine, Newcastle University, Newcastle, UK., Banks E; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Ingelsson E; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Im HK; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hanover, Germany.; Institute for Human Genetics, Hannover Medical School, Hanover, Germany., Franks PW; Department of Clinical Sciences, Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Buck G; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Trakalo J; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Buck D; High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Prokopenko I; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Farjoun Y; Data Sciences and Data Engineering, Broad Institute, Cambridge, Massachusetts, USA., Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Gloyn AL; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Tuomi T; Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Kooner JS; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Lee JY; Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Park T; Department of Statistics, Seoul National University, Seoul, Republic of Korea.; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea., Donnelly P; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Morris AD; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK.; The Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Atzmon G; Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA.; Department of Natural Science, University of Haifa, Haifa, Israel., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Laakso M; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Strom TM; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Bell GI; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, USA., Blangero J; South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas Rio Grande Valley, Brownsville, Texas, USA., Duggirala R; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.; Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School Singapore, Singapore., McVean G; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Seielstad M; Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA.; Blood Systems Research Institute, San Francisco, California, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Meigs JB; General Medicine Division, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Cox NJ; Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, USA., Sladek R; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada., Lander ES; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Gabriel S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Burtt NP; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Kang HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Altshuler D; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., McCarthy MI; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
Publikováno v:
Nature [Nature] 2016 Aug 04; Vol. 536 (7614), pp. 41-47. Date of Electronic Publication: 2016 Jul 11.
Autor:
Chami N; Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Montreal Heart Institute, Montréal, QC H1T 1C8, Canada., Chen MH; Population Sciences Branch, National Heart, Lung, and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, USA., Slater AJ; Genetics Target Sciences, GlaxoSmithKline, Research Triangle Park, NC 27709, USA; OmicSoft Corporation, Cary, NC 27513, USA., Eicher JD; Population Sciences Branch, National Heart, Lung, and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, USA., Evangelou E; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece., Tajuddin SM; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Love-Gregory L; Department of Medicine, Center of Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA., Kacprowski T; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine, Greifswald and Ernst-Mortiz-Arndt University Greifswald, Greifswald 17475, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald QA, Germany., Schick UM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10069, USA., Nomura A; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Cardiovascular Medicine, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa 9200942, Japan., Giri A; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN 37235, USA., Lessard S; Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Montreal Heart Institute, Montréal, QC H1T 1C8, Canada., Brody JA; Department of Medicine, University of Washington, Seattle, WA 98101, USA., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10069, USA; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10069, USA., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55454, USA., Yanek LR; Department of Medicine/Division of General Internal Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA., Pazoki R; Department of Epidemiology, Erasmus, MC Rotterdam 3000, the Netherlands., Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Hill WD; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA., Burt A; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA., Bartz TM; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Becker DM; Department of Medicine/Division of General Internal Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA., Becker LC; Department of Medicine/Divisions of Cardiology and General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Bork-Jensen J; The Novo Nordisk Foundation, Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10069, USA., O'Donoghue ML; TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA., Crosslin DR; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA 98195, USA., de Denus S; Montreal Heart Institute, Montréal, QC H1T 1C8, Canada; Faculty of Pharmacy, Université de Montréal, Montréal, QC H3T 1J4, Canada., Dubé MP; Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Montreal Heart Institute, Montréal, QC H1T 1C8, Canada., Elliott P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK., Engström G; Department of Clinical Sciences, Malmö, Lund University, Malmö 221 00, Sweden; Skåne University Hospital, Malmö 222 41, Sweden., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Floyd JS; Department of Medicine, University of Washington, Seattle, WA 98101, USA., Fornage M; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Gao H; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK., Greinacher A; Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Gudnason V; Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland., Hansen T; The Novo Nordisk Foundation, Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark., Harris TB; Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, NIH, Bethesda, MD 20892, USA., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Hernesniemi J; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland; University of Tampere, School of Medicine, Tampere 33014, Finland., Highland HM; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Hirschhorn JN; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Department of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA., Hofman A; Department of Epidemiology, Erasmus, MC Rotterdam 3000, the Netherlands; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA., Irvin MR; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33014, Finland., Lange E; Departments of Genetics and Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Launer LJ; Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, NIH, Bethesda, MD 20892, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland., Li J; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, School of Medicine, Palo Alto, CA 94305, USA., Liewald DC; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Linneberg A; Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen 2600, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Glostrup 2100, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10069, USA; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10069, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland., Mägi R; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Mathias RA; Department of Medicine, Divisions of Allergy and Clinical Immunology and General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Melander O; Department of Clinical Sciences, Malmö, Lund University, Malmö 221 00, Sweden; Skåne University Hospital, Malmö 222 41, Sweden., Metspalu A; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA., Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, WA 98105, USA., Nikus K; University of Tampere, School of Medicine, Tampere 33014, Finland; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere 33521, Finland., O'Donnell CJ; Population Sciences Branch, National Heart, Lung, and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, USA; Cardiology Section and Center for Population Genomics, Boston Veteran's Administration (VA) Healthcare, Boston, MA 02118, USA., Orho-Melander M; Department of Clinical Sciences, Malmö, Lund University, Malmö 221 00, Sweden; Skåne University Hospital, Malmö 222 41, Sweden., Pedersen O; The Novo Nordisk Foundation, Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark., Petersmann A; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Polfus L; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine Epidemiology and Health Services, University of Washington, Seattle, WA 98101, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland., Raitoharju E; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland., Richard M; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Rivadeneira F; Department of Epidemiology, Erasmus, MC Rotterdam 3000, the Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam 3000, the Netherlands; Netherlands Consortium for Healthy Ageing (NCHA), Rotterdam 3015, the Netherlands., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Schmidt F; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine, Greifswald and Ernst-Mortiz-Arndt University Greifswald, Greifswald 17475, Germany., Smith AV; Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer Scotland Research Centre, Edinburgh EH8 9JZ, UK., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Thuesen BH; Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen 2600, Denmark., Torstenson ES; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN 37235, USA., Tracy RP; Departments of Pathology and Laboratory Medicine and Biochemistry, University of Vermont College of Medicine, Colchester, VT 05446, USA., Tzoulaki I; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece., Zakai NA; Departments of Medicine and Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA., Vacchi-Suzzi C; Department of Family Population and Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA., van Duijn CM; Department of Epidemiology, Erasmus, MC Rotterdam 3000, the Netherlands., van Rooij FJ; Department of Epidemiology, Erasmus, MC Rotterdam 3000, the Netherlands., Cushman M; Departments of Medicine and Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Velez Edwards DR; Vanderbilt Epidemiology Center, Department of Obstetrics & Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN 37203, USA., Vergnaud AC; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK., Wallentin L; Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala 751 85, Sweden., Waterworth DM; Genetics Target Sciences, GlaxoSmithKline, King of Prussia, PA 19406, USA., White HD; Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland 1142, New Zealand., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Kathiresan S; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Grarup N; The Novo Nordisk Foundation, Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark., Esko T; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10069, USA; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10069, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10069, USA., Lange LA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA., Faraday N; Department of Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Abumrad NA; Department of Medicine, Center of Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA., Edwards TL; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN 37235, USA., Ganesh SK; Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48108, USA., Auer PL; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI 53205, USA., Johnson AD; Population Sciences Branch, National Heart, Lung, and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: apreiner@u.washington.edu., Lettre G; Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Montreal Heart Institute, Montréal, QC H1T 1C8, Canada. Electronic address: guillaume.lettre@umontreal.ca.
Publikováno v:
American journal of human genetics [Am J Hum Genet] 2016 Jul 07; Vol. 99 (1), pp. 8-21. Date of Electronic Publication: 2016 Jun 23.
Autor:
Wessel J; 1] Department of Epidemiology, Fairbanks School of Public Health, Indianapolis, Indiana 46202, USA [2] Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA., Chu AY; 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA [2] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA., Willems SM; 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands [2] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK., Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Brody JA; 1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, Seattle, Washington 98195, USA., Dauriz M; 1] Massachusetts General Hospital, General Medicine Division, Boston, Massachusetts 02114, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona Medical School and Hospital Trust of Verona, Verona 37126, Italy., Hivert MF; 1] Harvard Pilgrim Health Care Institute, Department of Population Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA [2] Division of Endocrinology and Metabolism, Department of Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1 [3] Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Raghavan S; 1] Massachusetts General Hospital, General Medicine Division, Boston, Massachusetts 02114, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA., Lipovich L; 1] Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan 48201, USA [2] Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48202, USA., Hidalgo B; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA., Fox K; 1] Department of Medicine, University of Washington, Seattle, Washington 98195, USA [2] Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA., Huffman JE; 1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA [2] MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, Scotland EH4 2XU, UK., An P; Division of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA., Lu Y; 1] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Ehm MG; Quantitative Sciences, PCPS, GlaxoSmithKline, North Carolina 27709, USA., Li L; Quantitative Sciences, PCPS, GlaxoSmithKline, North Carolina 27709, USA., Baldridge AS; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio FI-70211, Finland., Abrol R; 1] Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Materials and Process Simulation Center, California Institute of Technology, Pasadena, California 91125, USA., Besse C; CEA, Institut de Génomique, Centre National de Génotypage, 2 Rue Gaston Crémieux, EVRY Cedex 91057, France., Boland A; CEA, Institut de Génomique, Centre National de Génotypage, 2 Rue Gaston Crémieux, EVRY Cedex 91057, France., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA., Freitag DF; 1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK., Garcia ME; Intramural Research Program, National Institute on Aging, Bethesda, Maryland 21224, USA., Guo X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Hara K; 1] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands., Jakobsdottir J; Icelandic Heart Association, Holtasmari 1, Kopavogur IS-201, Iceland., Lange LA; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Layton JC; Indiana University, Fairbanks School of Public Health, Indianapolis, Indiana 46202, USA., Li M; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21205, USA., Hua Zhao J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal DE-14558, Germany., Morrison AC; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77225, USA., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA., Peters MJ; 1] Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands [2] The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/Rotterdam 2300 RC, The Netherlands., Sabater-Lleal M; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden., Schurmann C; 1] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Silveira A; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden., Smith AV; 1] Icelandic Heart Association, Holtasmari 1, Kopavogur IS-201, Iceland [2] University of Iceland, Reykjavik IS-101, Iceland., Southam L; 1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK., Stoiber MH; Department of Genome Dynamics, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA., Strawbridge RJ; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö SE-205 02, Sweden., Allin KH; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands., Aponte JL; Quantitative Sciences, PCPS, GlaxoSmithKline, North Carolina 27709, USA., Aung T; 1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore., Barbieri C; Division of Genetics and Cell Biology, San Raffaele Research Institute, Milano 20132, Italy., Bihlmeyer NA; 1] Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Maryland 21205, USA [2] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Bombieri C; Section of Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona 37100, Italy., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Burns SM; Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Chen YD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Cheng CY; 1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 119228, Singapore [4] Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA., Czajkowski J; Division of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA., Dehghan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands., Ehret GB; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA [2] Division of Cardiology, Geneva University Hospital Geneva 1211, Switzerland., Eiriksdottir G; Icelandic Heart Association, Holtasmari 1, Kopavogur IS-201, Iceland., Escher SA; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö SE-205 02, Sweden., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens 17671, Greece., Frånberg M; 1] Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden [2] Department of Numerical Analysis and Computer Science, SciLifeLab, Stockholm University, Stockholm SE-106 91, Sweden., Gambaro G; Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University, Rome 00168, Italy., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Goddard WA 3rd; Materials and Process Simulation Center, California Institute of Technology, Pasadena, California 91125, USA., Goel A; Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Grove ML; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77225, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala SE-751 85, Sweden., Hai Y; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Hallmans G; Department of Biobank Research, Umeå University, Umeå SE-901 87, Sweden., Heo J; Department of Biomedical Technology, Sangmyung University, Chungnam 330-720, Korea., Hoffmann P; 1] Institute of Human Genetics, Department of Genomics, Life &Brain Center, University of Bonn, Bonn DE-53127, Germany [2] Human Genomics Research Group, Division of Medical Genetics, University Hospital Basel Department of Biomedicine 4031, Basel, Switzerland [3] Institute of Neuroscience and Medicine (INM-1) Genomic Imaging Research Center Juelich, Juelich DE-52425, Germany., Ikram MK; 1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore [3] Memory Aging &Cognition Centre (MACC), National University Health System, Singapore 117599, Singapore., Jensen RA; 1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, Seattle, Washington 98195, USA., Jørgensen ME; Steno Diabetes Center, Gentofte DK-2820, Denmark., Jørgensen T; 1] Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup DK-2600, Denmark [2] Faculty of Medicine, University of Aalborg, Aalborg DK-9220, Denmark., Karaleftheri M; Echinos Medical Centre, Echinos 67300, Greece., Khor CC; 1] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [2] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore., Kirkpatrick A; Materials and Process Simulation Center, California Institute of Technology, Pasadena, California 91125, USA., Kraja AT; Division of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio FI-70211, Finland., Lange EM; 1] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA [2] Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Lee IT; 1] Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan [2] School of Medicine, National Yang-Ming University, Taipei 112, Taiwan., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan., Leong A; 1] Massachusetts General Hospital, General Medicine Division, Boston, Massachusetts 02114, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA., Liao J; 1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore., Liu C; National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA., Liu Y; Department of Epidemiology &Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina 27106, USA., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Linneberg A; 1] Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup DK-2600, Denmark [2] Department of Clinical Experimental Research, Copenhagen University Hospital Glostrup, Glostrup DK-2600, Denmark [3] Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Malerba G; Section of Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona 37100, Italy., Mamakou V; 1] National and Kapodistrian University of Athens, Faculty of Medicine, Athens 115 27, Greece [2] Dromokaiteio Psychiatric Hospital, Athens 124 61, Greece., Marouli E; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens 17671, Greece., Maruthur NM; 1] Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21205, USA., Matchan A; The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK., McKean-Cowdin R; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA., McLeod O; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden., Metcalf GA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Muzny DM; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA., Ntalla I; 1] Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens 17671, Greece [2] University of Leicester, Leicester LE1 7RH, UK., Palmer ND; 1] Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA [2] Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27106, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Peter A; 1] Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry and Institute of Diabetes Research and Metabolic Diseases, University of Tübingen, Tübingen DE-72076, Germany [2] German Center for Diabetes Research (DZD), Neuherberg DE-85764, Germany., Rayner NW; 1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK [3] The Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LE, UK., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö SE-205 02, Sweden., Rice K; 1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Sala CF; Division of Genetics and Cell Biology, San Raffaele Research Institute, Milano 20132, Italy., Sennblad B; 1] Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden [2] Science for Life Laboratory, Karolinska Institutet, Stockholm SE-171 77, Sweden., Serafetinidis I; Department of Gastroenterology, Gennimatas General Hospital, Athens 11527, Greece., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Soranzo N; 1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] Department of Hematology, Long Road, Cambridge CB2 0XY, UK., Speliotes EK; Department of Internal Medicine, Division of Gastroenterology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Stahl EA; Division of Psychiatric Genomics, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Stirrups K; 1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK., Tentolouris N; First Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, Athens 11527, Greece., Thanopoulou A; Diabetes Centre, 2nd Department of Internal Medicine, National University of Athens, Hippokration General Hospital, Athens 11527, Greece., Torres M; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA., Traglia M; Division of Genetics and Cell Biology, San Raffaele Research Institute, Milano 20132, Italy., Tsafantakis E; Anogia Medical Centre, Anogia 740 51, Greece., Javad S; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK., Yanek LR; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Zengini E; 1] Dromokaiteio Psychiatric Hospital, Athens 124 61, Greece [2] University of Sheffield, Sheffield S10 2TN, UK., Becker DM; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Bis JC; 1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, Seattle, Washington 98195, USA., Brown JB; 1] Department of Genome Dynamics, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA [2] Department of Statistics, University of California at Berkeley, Berkeley, California 94720, USA., Cupples LA; 1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA [2] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Hansen T; 1] The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark [2] Faculty of Health Science, University of Copenhagen, Copenhagen 1165, Denmark., Ingelsson E; 1] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala SE-751 85, Sweden [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Karter AJ; Division of Research, Kaiser Permanente, Northern California Region, Oakland, California 94612, USA., Lorenzo C; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 77030, USA., Mathias RA; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Norris JM; Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado 80204, USA., Peloso GM; 1] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA [2] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Sheu WH; 1] Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan [2] School of Medicine, National Yang-Ming University, Taipei 112, Taiwan [3] College of Medicine, National Defense Medical Center, Taipei 114, Taiwan., Toniolo D; Division of Genetics and Cell Biology, San Raffaele Research Institute, Milano 20132, Italy., Vaidya D; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Varma R; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA., Wagenknecht LE; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27106, USA., Boeing H; Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrücke, Nuthetal DE-14558, Germany., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens 17671, Greece., Deloukas P; 1] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK [2] Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK [3] Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 22254, Saudi Arabia., Ferrannini E; CNR Institute of Clinical Physiology, Pisa 73100, Italy., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands., Franks PW; 1] Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö SE-205 02, Sweden [2] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA [3] Department of Public Health &Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA., Gudnason V; 1] Icelandic Heart Association, Holtasmari 1, Kopavogur IS-201, Iceland [2] University of Iceland, Reykjavik IS-101, Iceland., Hamsten A; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden., Harris TB; Intramural Research Program, National Institute on Aging, Bethesda, Maryland 21224, USA., Hattersley AT; Genetics of Diabetes, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Hayward C; MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, Scotland EH4 2XU, UK., Hofman A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands., Jansson JH; 1] Department of Public Health &Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden [2] Research Unit, Skellefteå SE-931 87, Sweden., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK., Launer LJ; Intramural Research Program, National Institute on Aging, Bethesda, Maryland 21224, USA., Levy D; 1] Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA [2] Framingham Heart Study, Framingham, Massachusetts 01702, USA., Oostra BA; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands., O'Donnell CJ; 1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., O'Rahilly S; University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 1TN, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA., Polasek O; Department of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia., Province MA; Division of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA., Rich SS; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia 22908, USA., Ridker PM; 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA [2] Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Rudan I; Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland EH8 9YL, UK., Schulze MB; 1] Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal DE-14558, Germany [2] German Center for Diabetes Research (DZD), Neuherberg DE-85764, Germany., Smith BH; Medical Research Institute, University of Dundee, Dundee DD1 9SY, UK., Uitterlinden AG; 1] Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands [2] Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne NE1 7RU, UK., Watkins H; Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Wong TY; 1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore., Zeggini E; The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio FI-70211, Finland., Borecki IB; Division of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA., Chasman DI; 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA [2] Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Psaty BM; 1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, Seattle, Washington 98195, USA [3] Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA [4] Department of Health Services, University of Washington, Seattle, Washington 98195, USA [5] Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98195, USA., Tai ES; 1] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 119228, Singapore [2] Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., van Duijn CM; 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands [2] Center for Medical Systems Biology, Leiden 2300, The Netherlands., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK., Waterworth DM; Genetics, PCPS, GlaxoSmithKline, Philadelphia, Pennsylvania 19104, USA., Boerwinkle E; 1] Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77225, USA [2] Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA., Kao WH; 1] Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21205, USA [2] Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21205, USA [3] Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA., Florez JC; 1] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA [4] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Loos RJ; 1] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [3] The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 38677, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Siscovick DS; 1] New York Academy of Medicine, New York, New York 10029, USA [2] Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98195, USA., Dupuis J; 1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA [2] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Meigs JB; 1] Massachusetts General Hospital, General Medicine Division, Boston, Massachusetts 02114, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK., Goodarzi MO; 1] Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Publikováno v:
Nature communications [Nat Commun] 2015 Jan 29; Vol. 6, pp. 5897. Date of Electronic Publication: 2015 Jan 29.
Genetic variation in alcohol metabolizing enzymes among Inuit and its relation to drinking patterns.
Autor:
Bjerregaard P; National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5A, 1353 Copenhagen K, Denmark; Greenland Centre for Health Research, University of Greenland, 3900 Nuuk, Greenland. Electronic address: pb@niph.dk., Mikkelsen SS; National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5A, 1353 Copenhagen K, Denmark., Becker U; National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5A, 1353 Copenhagen K, Denmark; Gastrounit, Medical Division, Copenhagen University Hospital Hvidovre, Kettegård Alle 30, 2650 Hvidovre, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Universitetsparken 1, 2100 Copenhagen, Denmark., Tolstrup JS; National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5A, 1353 Copenhagen K, Denmark.
Publikováno v:
Drug and alcohol dependence [Drug Alcohol Depend] 2014 Nov 01; Vol. 144, pp. 239-44. Date of Electronic Publication: 2014 Sep 28.