Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vincent W. Keng"'
Publikováno v:
Biochemical and Biophysical Research Communications. 541:70-77
A forward genetic Sleeping Beauty (SB) insertional mutagenesis screen, followed by high-throughput transcriptome sequencing, was used to identify driver genes responsible for hepatocellular carcinoma (HCC)-associated metastasis. Using RNA-sequencing
Autor:
Lewis R. Roberts, Robert Hullsiek, Lindsey A. Lee, Wendy A. Hudson, Barbara R. Tschida, Timothy P. Kuka, Michael A. Linden, Vincent W. Keng, Sandra Wagner, David A. Largaespada, Rachel A. Heuer, Pauline J. Beckmann, Nuri A. Temiz, Khalid Amin, Jesse D. Riordan, Joseph H. Nadeau, Ju Dong Yang, Adam J. Dupuy, Carlos A. Tierrablanca, Aaron L. Sarver
Publikováno v:
Cancer Research. 77:6576-6588
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using Sleeping Beauty
Autor:
Stephen C. Schmechel, David A. Largaespada, Vincent W. Keng, Anthony E. Rizzardi, Margaret H. Collins, Colleen L. Forster, Amanda L. Halfond, Caitlin B. Conboy, Eric P. Rahrmann, Aaron L. Sarver, Andrew D. Greeley, Adrienne L. Watson, Nancy Ratner, Margaret R. Wallace, Leah K. Anderson, Kwangmin Choi, Branden S. Moriarity, Brian R. Wahl
Publikováno v:
Cancer Discovery. 3:674-689
Genetic changes required for the formation and progression of human Schwann cell tumors remain elusive. Using a Sleeping Beauty forward genetic screen, we identified several genes involved in canonical Wnt signaling as potential drivers of benign neu
Autor:
Christopher L. Moertel, Adrienne L. Watson, Vincent W. Keng, David A. Largaespada, Natalie K. Wolf, Bernat Gel, Dominic A. Beckmann, Margaret H. Collins, Eduard Serra, Margaret R. Wallace, Aaron L. Sarver, Branden S. Moriarity, Kwangmin Choi, Nancy Ratner, Eric P. Rahrmann
Publikováno v:
Nature genetics
Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas of Schwann cell lineage origin that occur sporadically or in association with the inherited syndrome neurofibromatosis type 1. To identify genetic drivers of MPNST development, we used th
Abstract 63: A transposon-based forward genetic screen for steatosis-associated liver cancer drivers
Publikováno v:
Cancer Research. 76:63-63
Hepatocellular carcinoma (HCC), or liver cancer, is the second leading cause of death from cancer worldwide (Ferlay et al, Lyon, France: International Agency for Research on Cancer, 2013). HCC is linked with hepatic steatosis, or fatty liver disease,
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer
Autor:
Jef D. Boeke, Wei Rose Xie, Erin L. Reineke, Bert W. O'Malley, David A. Largaespada, Vincent W. Keng, Loris Mularoni, Michael Torbenson, Danhua Fan, Kathryn A. O'Donnell, Sarah J. Wheelan, Brian York, Kevin A. T. Silverstein, Christina T. Schrum, Daekwan Seo
The Sleeping Beauty ( SB ) transposon mutagenesis system is a powerful tool that facilitates the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify mutations that cooperate with MYC , one of the most commonly d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd78fe674776140ab4f45b3df0b55f4d
https://europepmc.org/articles/PMC3361419/
https://europepmc.org/articles/PMC3361419/
Autor:
Timothy P. Kuka, Jason B. Bell, Branden S. Moriarity, Vincent W. Keng, David A. Largaespada, Barbara R. Tschida
Publikováno v:
Cancer Research. 74:929-929
The role of zinc finger and BTB domain containing 20 (ZBTB20) in hepatocellular carcinoma (HCC) is not well defined, as there are many discrepancies in the literature regarding its role in liver tumorigenesis. ZBTB20 has been implicated to play a rol
Autor:
Kevin A. T. Silverstein, David A. Largaespada, Neal G. Copeland, Vincent W. Keng, Aaron L. Sarver, Adam J. Dupuy, Danhua Fan, Barbara J. Ryan, Nancy A. Jenkins
Publikováno v:
Cancer Research. 70:4182-4182
Introduction: Hepatocellular carcinoma (HCC) is a deadly disease where many of the underlying associated genetic mechanisms remain undiscovered. Although HCC has been relatively rare in the US, the growing number of patients with cirrhosis (due to he