Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Broome, Jai"'
Autor:
Bick AG; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Weinstock JS; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Nandakumar SK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Bao EL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA., Zekavat SM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Yale School of Medicine, New Haven, CT, USA., Szeto MD; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Liao X; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Leventhal MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chang K; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Laurie C; Department of Biostatistics, University of Washington, Seattle, WA, USA., Burugula BB; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Gibson CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lin AE; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Taub MA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Aguet F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ardlie K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Barnes KC; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA., Moscati A; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Redline S; Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Silverman EK; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Weiss ST; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Vasan RS; Departments of Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA., Burchard EG; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.; Tulane University Translational Science Institute, New Orleans, LA, USA., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Seattle Epidemiologic Information and Research Center, Department of Veterans Affairs, Office of Research and Development, Seattle, WA, USA., Arnett DK; College of Public Health, University of Kentucky, Lexington, KY, USA., Schwartz DA; Department of Medicine, University of Colorado, Aurora, CO, USA., Correa A; Departments of Medicine and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA., de Andrade M; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Guo X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Konkle BA; Bloodworks Northwest, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Custer B; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Peralta JM; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Gui H; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA., Meyers DA; Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA., McGarvey ST; Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI, USA., Chen IY; Medical Genetics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA, USA., Shoemaker MB; Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Broome JG; Department of Biostatistics, University of Washington, Seattle, WA, USA., Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Wang FF; Department of Biostatistics, University of Washington, Seattle, WA, USA., Wong Q; Department of Biostatistics, University of Washington, Seattle, WA, USA., Montasser ME; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Daya M; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Kenny EE; Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., North KE; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Launer LJ; Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA., Cade BE; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Cho MH; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Lasky-Su J; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Cupples LA; Departments of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, MA, USA., Mak ACY; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Becker LC; GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Kelly TN; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.; Tulane University Translational Science Institute, New Orleans, LA, USA., Aslibekyan S; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Heckbert SR; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Tiwari HK; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA., Yang IV; Department of Medicine, University of Colorado, Aurora, CO, USA., Heit JA; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA., Lubitz SA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Johnsen JM; Bloodworks Northwest, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Wenzel SE; Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Weeks DE; Departments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Rao DC; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA., Darbar D; Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA., Moon JY; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Tracy RP; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Buth EJ; Department of Biostatistics, University of Washington, Seattle, WA, USA., Rafaels N; Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Durda P; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Liu Y; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA., Hou L; Department of Preventive Medicine, Northwestern Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Lee J; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Kachroo P; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Levy D; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Hixson JE; Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Ellinor PT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Fingerlin TE; Center for Genes Environment and Health, National Jewish Health, Denver, CO, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Armasu SM; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Wheeler MM; Department of Genome Science, University of Washington, Seattle, WA, USA., Sabino EC; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Williams LK; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA., Levy BD; Harvard Medical School, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Boerwinkle E; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Manson JE; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA., Mathias RA; GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Desai P; Department of Medicine, Weill Cornell Medical School, New York, NY, USA., Taylor KD; Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA., Johnson AD; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Auer PL; Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Blackwell TW; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Smith AV; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Zhao H; Department of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA.; Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA., Lange E; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lange L; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Rich SS; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Scheet P; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kitzman JO; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Society of Fellows, Harvard University, Cambridge, MA, USA., Ebert BL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Jaiswal S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Abecasis G; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Sankaran VG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Kathiresan S; Broad Institute of MIT and Harvard, Cambridge, MA, USA. sekar@broadinstitute.org.; Harvard Medical School, Boston, MA, USA. sekar@broadinstitute.org.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. sekar@broadinstitute.org.; Verve Therapeutics, Cambridge, MA, USA. sekar@broadinstitute.org., Natarajan P; Broad Institute of MIT and Harvard, Cambridge, MA, USA. pradeep@broadinstitute.org.; Harvard Medical School, Boston, MA, USA. pradeep@broadinstitute.org.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. pradeep@broadinstitute.org.
Publikováno v:
Nature [Nature] 2020 Oct; Vol. 586 (7831), pp. 763-768. Date of Electronic Publication: 2020 Oct 14.
Autor:
Li X; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Li Z; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Zhou H; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Gaynor SM; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Liu Y; School of Statistics, Southwestern University of Finance and Economics, Chengdu, China., Chen H; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Center for Precision Health, School of Public Health and School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA., Sun R; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dey R; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Arnett DK; College of Public Health, University of Kentucky, Lexington, KY, USA., Aslibekyan S; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Ballantyne CM; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Bowden DW; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Broome JG; Division of Medical Genetics, University of Washington, Seattle, WA, USA., Conomos MP; Department of Biostatistics, University of Washington, Seattle, WA, USA., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, MA, USA., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA., Freedman BI; Department of Internal Medicine, Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Hindy G; Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kathiresan S; Verve Therapeutics, Cambridge, MA, USA.; Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Khan AT; Department of Biostatistics, University of Washington, Seattle, WA, USA., Kooperberg CL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Liu XS; Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Statistics, Harvard University, Cambridge, MA, USA., Mahaney MC; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA., Manichaikul AW; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Martin LW; Division of Cardiology, George Washington School of Medicine and Health Sciences, Washington, DC, USA., Mathias RA; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., McGarvey ST; Department of Epidemiology, International Health Institute, Department of Anthropology, Brown University, Providence, RI, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore VA Medical Center, Baltimore, MD, USA., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Moore JE; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., O'Connell JR; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Palmer ND; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Pampana A; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Peralta JM; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Tiwari HK; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Tsai MY; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Vasan RS; Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, MA, USA.; Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Wang FF; Department of Biostatistics, University of Washington, Seattle, WA, USA., Weeks DE; Department of Human Genetics and Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA., Weng Z; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Yanek LR; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Neale BM; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Sunyaev SR; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Abecasis GR; Regeneron Pharmaceuticals, Tarrytown, NY, USA.; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Willer CJ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Natarajan P; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Lin X; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. xlin@hsph.harvard.edu.; Department of Statistics, Harvard University, Cambridge, MA, USA. xlin@hsph.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. xlin@hsph.harvard.edu.
Publikováno v:
Nature genetics [Nat Genet] 2020 Sep; Vol. 52 (9), pp. 969-983. Date of Electronic Publication: 2020 Aug 24.
Autor:
Mikhaylova, Anna V, McHugh, Caitlin P, Polfus, Linda M, Raffield, Laura M, Boorgula, Meher Preethi, Blackwell, Thomas W, Brody, Jennifer A, Broome, Jai, Chami, Nathalie, Chen, Ming-Huei, Conomos, Matthew P, Cox, Corey, Curran, Joanne E, Daya, Michelle, Ekunwe, Lynette, Glahn, David C, Heard-Costa, Nancy, Highland, Heather M, Hobbs, Brian D, Ilboudo, Yann, Jain, Deepti, Lange, Leslie A, Miller-Fleming, Tyne W, Min, Nancy, Moon, Jee-Young, Preuss, Michael H, Rosen, Jonathon, Ryan, Kathleen, Smith, Albert V, Sun, Quan, Surendran, Praveen, de Vries, Paul S, Walter, Klaudia, Wang, Zhe, Wheeler, Marsha, Yanek, Lisa R, Zhong, Xue, Abecasis, Goncalo R, Almasy, Laura, Barnes, Kathleen C, Beaty, Terri H, Becker, Lewis C, Blangero, John, Boerwinkle, Eric, Butterworth, Adam S, Chavan, Sameer, Cho, Michael H, Choquet, Hélène, Correa, Adolfo, Cox, Nancy, DeMeo, Dawn L, Faraday, Nauder, Fornage, Myriam, Gerszten, Robert E, Hou, Lifang, Johnson, Andrew D, Jorgenson, Eric, Kaplan, Robert, Kooperberg, Charles, Kundu, Kousik, Laurie, Cecelia A, Lettre, Guillaume, Lewis, Joshua P, Li, Bingshan, Li, Yun, Lloyd-Jones, Donald M, Loos, Ruth JF, Manichaikul, Ani, Meyers, Deborah A, Mitchell, Braxton D, Morrison, Alanna C, Ngo, Debby, Nickerson, Deborah A, Nongmaithem, Suraj, North, Kari E, O'Connell, Jeffrey R, Ortega, Victor E, Pankratz, Nathan, Perry, James A, Psaty, Bruce M, Rich, Stephen S, Soranzo, Nicole, Rotter, Jerome I, Silverman, Edwin K, Smith, Nicholas L, Tang, Hua, Tracy, Russell P, Thornton, Timothy A, Vasan, Ramachandran S, Zein, Joe, Mathias, Rasika A, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Reiner, Alexander P, Auer, Paul L
Publikováno v:
American journal of human genetics, vol 108, iss 10
Many common and rare variants associated with hematologic traits have been discovered through imputation on large-scale reference panels. However, the majority of genome-wide association studies (GWASs) have been conducted in Europeans, and determini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::1f3a94426432e7d8d437082d4c6c39d7
https://escholarship.org/uc/item/6432c6xx
https://escholarship.org/uc/item/6432c6xx
Autor:
Bick, Alexander G, Weinstock, Joshua S, Nandakumar, Satish K, Fulco, Charles P, Bao, Erik L, Zekavat, Seyedeh M, Szeto, Mindy D, Liao, Xiaotian, Leventhal, Matthew J, Nasser, Joseph, Chang, Kyle, Laurie, Cecelia, Burugula, Bala Bharathi, Gibson, Christopher J, Lin, Amy E, Taub, Margaret A, Aguet, Francois, Ardlie, Kristin, Mitchell, Braxton D, Barnes, Kathleen C, Moscati, Arden, Fornage, Myriam, Redline, Susan, Psaty, Bruce M, Silverman, Edwin K, Weiss, Scott T, Palmer, Nicholette D, Vasan, Ramachandran S, Burchard, Esteban G, Kardia, Sharon LR, He, Jiang, Kaplan, Robert C, Smith, Nicholas L, Arnett, Donna K, Schwartz, David A, Correa, Adolfo, de Andrade, Mariza, Guo, Xiuqing, Konkle, Barbara A, Custer, Brian, Peralta, Juan M, Gui, Hongsheng, Meyers, Deborah A, McGarvey, Stephen T, Chen, Ida Yii-Der, Shoemaker, M Benjamin, Peyser, Patricia A, Broome, Jai G, Gogarten, Stephanie M, Wang, Fei Fei, Wong, Quenna, Montasser, May E, Daya, Michelle, Kenny, Eimear E, North, Kari E, Launer, Lenore J, Cade, Brian E, Bis, Joshua C, Cho, Michael H, Lasky-Su, Jessica, Bowden, Donald W, Cupples, L Adrienne, Mak, Angel CY, Becker, Lewis C, Smith, Jennifer A, Kelly, Tanika N, Aslibekyan, Stella, Heckbert, Susan R, Tiwari, Hemant K, Yang, Ivana V, Heit, John A, Lubitz, Steven A, Johnsen, Jill M, Curran, Joanne E, Wenzel, Sally E, Weeks, Daniel E, Rao, Dabeeru C, Darbar, Dawood, Moon, Jee-Young, Tracy, Russell P, Buth, Erin J, Rafaels, Nicholas, Loos, Ruth JF, Durda, Peter, Liu, Yongmei, Hou, Lifang, Lee, Jiwon, Kachroo, Priyadarshini, Freedman, Barry I, Levy, Daniel, Bielak, Lawrence F, Hixson, James E, Floyd, James S, Whitsel, Eric A, Ellinor, Patrick T, Irvin, Marguerite R, Fingerlin, Tasha E, Raffield, Laura M, Armasu, Sebastian M, Wheeler, Marsha M
Publikováno v:
Nature, vol 586, iss 7831
Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown1. The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7a0a8f97539e2476439614239fdd3d58
https://escholarship.org/uc/item/7w16b34n
https://escholarship.org/uc/item/7w16b34n
Autor:
Li, Xihao, Li, Zilin, Zhou, Hufeng, Gaynor, Sheila M, Liu, Yaowu, Chen, Han, Sun, Ryan, Dey, Rounak, Arnett, Donna K, Aslibekyan, Stella, Ballantyne, Christie M, Bielak, Lawrence F, Blangero, John, Boerwinkle, Eric, Bowden, Donald W, Broome, Jai G, Conomos, Matthew P, Correa, Adolfo, Cupples, L Adrienne, Curran, Joanne E, Freedman, Barry I, Guo, Xiuqing, Hindy, George, Irvin, Marguerite R, Kardia, Sharon LR, Kathiresan, Sekar, Khan, Alyna T, Kooperberg, Charles L, Laurie, Cathy C, Liu, X Shirley, Mahaney, Michael C, Manichaikul, Ani W, Martin, Lisa W, Mathias, Rasika A, McGarvey, Stephen T, Mitchell, Braxton D, Montasser, May E, Moore, Jill E, Morrison, Alanna C, O'Connell, Jeffrey R, Palmer, Nicholette D, Pampana, Akhil, Peralta, Juan M, Peyser, Patricia A, Psaty, Bruce M, Redline, Susan, Rice, Kenneth M, Rich, Stephen S, Smith, Jennifer A, Tiwari, Hemant K, Tsai, Michael Y, Vasan, Ramachandran S, Wang, Fei Fei, Weeks, Daniel E, Weng, Zhiping, Wilson, James G, Yanek, Lisa R, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lipids Working Group, Neale, Benjamin M, Sunyaev, Shamil R, Abecasis, Gonçalo R, Rotter, Jerome I, Willer, Cristen J, Peloso, Gina M, Natarajan, Pradeep, Lin, Xihong
Publikováno v:
Nature genetics, vol 52, iss 9
Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose STAAR (variant-set test f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e52aef530ecaa2ce04de16503b6abfa5
https://escholarship.org/uc/item/61s9b995
https://escholarship.org/uc/item/61s9b995