Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yujeong Lee"'
Publikováno v:
Journal of Alzheimer's Disease. 77:1-14
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease worldwide, but its cause remains unclear. Although a few drugs can provide temporary and partial relief of symptoms in some patients, no curative treatment is availab
Autor:
Seung-Cheol Chang, Hae Young Chung, Won-Jong Lee, Yujeong Lee, Seulah Lee, Hyung Ryong Moon, Jung-Hyun Cho, Jaewon Lee
Publikováno v:
Brain Research. 1704:47-58
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and are considered promising therapeutic targets in several neurodegenerative diseases. A number of PPAR agonists have been shown to have neuroprotective properties in the pres
Autor:
Yujeong Lee, Hyeyoung Jeon, Seonguk Yang, Ah Hyun Kim, Won-Jong Lee, Jung-Hyun Cho, Seulah Lee, Jaewon Lee, Jeanho Yun, Young-Suk Jung
Publikováno v:
Neurotoxicity research. 38(1)
Tetrabromobisphenol A (TBBPA) is widely used in materials like plastics and textiles as a fire retardant. In a previous study, we reported TBBPA might disrupt hippocampal neurogenesis and neurocognitive function in mice. However, the mechanism respon
PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice
Autor:
Young-Whan Choi, Ju Yeon Kim, Hye Jeong Chun, Jaewon Lee, Yujeong Lee, Hwa Kyoung Shin, Byung Tae Choi, Hee Ra Park, Cheol Min Kim
Publikováno v:
Neuroscience Letters. 617:254-263
The beneficial effects of traditional Korean medicine are recognized during the treatment of neurodegenerative conditions, such as, Alzheimer's disease and neurocognitive dysfunction, and recently, hippocampal neurogenesis has been reported to be ass
Publikováno v:
Neurotoxicity Research. 29:419-431
Methylglyoxal (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and threonine catabolism, and its accumulation is associated with various degenerative diseases, such as diabetes and arterial atherogenesis. Furt
Publikováno v:
Brain Research. 1627:233-242
Parkinson's disease (PD) is the second-most common neurodegenerative disease after Alzheimer's disease, and is characterized by dopaminergic neuronal loss in midbrain. The MPTP-induced PD model has been well characterized by motor deficits and select
Publikováno v:
Brain Research. 1730:146642
Neuroinflammation is often associated with astrocyte and microglial activations particularly in Parkinson’s disease (PD) and other brain damage such as Alzheimer’s disease. Therefore, the modulation of glial activation offers a possible target fo
Autor:
Ah Hyun Kim, Kyung Moon Lee, Hae Young Chung, Ki Wung Chung, Eunok Im, Gwangbeom Heo, Yujeong Lee, Jaewon Lee
Publikováno v:
Brain research. 1663
Neurons depend on mitochondria for homeostasis and survival, and thus, mitochondrial dysfunction has been implicated in neurodegenerative diseases, including Parkinson's disease (PD). Increasing evidence indicates the mitochondrial uncoupler, 2,4-din
Publikováno v:
Neuroscience Letters. 535:134-139
Mitochondria produce ATP, regulate apoptosis, and maintain calcium homeostasis, and thus, mitochondrial dysfunction critically impairs nervous system development. Furthermore, the disruption of oxidative phosphorylation (OXPHOS) in mitochondria could